Practical considerations regarding the influence of the menstrual cycle on leukocyte parameters in clinical trials

American Journal of Therapeutics

Volumn 7, Issue 5, 2000, Pages 297-302

  Apseloff, Glen ^a   Bao, Xiaohui ^a   Laboy Goral, Lucia ^b   Friedman, Hylar ^b   Shah, Ajit ^b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Absolute neutrophil counts; Leukocytes; Menstrual cycle

Indexed keywords

HEMOGLOBIN A;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL TRIAL; CYTOLOGY; FEMALE; HEMATOCRIT; HUMAN; LEUKOCYTE; LEUKOCYTE COUNT; LYMPHOCYTE; MENSTRUAL CYCLE; METABOLISM; NEUTROPHIL; PHYSIOLOGY; QUESTIONNAIRE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; FEMALE; HEMATOCRIT; HEMOGLOBIN A; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; LYMPHOCYTES; MENSTRUAL CYCLE; NEUTROPHILS; QUESTIONNAIRES;

EID: 0034280872     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200007050-00005     Document Type: Article

References (27)

1. Yussman MA, Taymor ML: Serum levels of follicle stimulating hormone and luteinizing hormone and of plasma progesterone related to ovulation by corpus luteum biopsy. J Clin Endocrinol 1970;30:396.
2. Riester EF, Pantuck EJ, Pantuck CB, et al: Antipyrine metabolism during the menstrual cycle. J Pharmacol Ther 1980;28:384-391.
3. Wojciki J, Gawronska-Szklarz B, Kazimierczyk J, et al: Comparative pharmacokinetics of paracetamol in men and women considering follicular and luteal phases. Arzneimittel Forschung 1979;29:350-352.
4. Bruguerolle B, Toumi M, Faraj F, et al: Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics. Eur J Clin Pharmacol 1990;39:59-61.
5. Lane JD, Steege JF, Rupp SL, et al: Menstrual cycle effects on caffeine elimination in the human female. Eur J Clin Pharmacol 1992;43:543-546.
6. Gerdin E, Rane A: N-Demethylation of ethylmorphine in pregnant and non-pregnant women and in men: An evaluation of the effects of sex steroids. Br J Clin Pharmacol 1992;34:250-255.
7. Wilson K: Sex-related differences in drug disposition in man. Clin Pharmacokinet 1984;9:189-202.
8. Kirkwood C, Moore A, Hayes P, et al: Influence of menstrual cycle and gender on alprazolam pharmacokinetics. Clin Pharmacol Ther 1991;50:404-409.
9. Greenblatt DJ, Abernethy DR, Locniskar A, et al: Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 1984;61:27-35.
10. Backstrom T, Jorpes P: Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy. Acta Neurol Scand 1979;59:63-71.
11. Bain BJ, England JM: Variations in leucocyte count during menstrual cycle. Br Med J 1975;2:473-475.
12. Mathur S, Mathur RS, Goust JM, et al: Cyclic variations in white cell subpopulations in the human menstrual cycle: Correlations with progesterone and estradiol. Clin Immunol Immunopath 1979;13:246-253.
13. Cruickshank JM, Morris R, Butt WR: The relationship of total and differential leukocyte counts with urinary oestrogen and plasma cortisol levels. J Obstet Gynaecol Br Commonwealth 1970;77:634-639.
14. Dirks M: Ueber Veränderungen des blutbildes bei der menstruation, bei menstruationsanomalien und in der menopause. Arch Gynäk 1912;97:583-595.
15. Maughan WZ, Bishop CR, Pryor TA, Athens JW: The question of cycling of the blood neutrophil concentrations and pitfalls in the statistical analysis of sampled data. Blood 1973;41:85-91.
16. Medlar EM: The extent of the variations in the leukocytes of normal individuals. Am J Med Sci 1929;177:72-87.
17. Rowe AW, Guagenty MC: A note on the menstrual influence on blood morphology. J Lab Clin Med 1934;20: 253-256.
18. MacKinnon IL: Observations on human leucocytes during the menstrual cycle. J Obstet Gynaec Br Emp 1949; 55:404-407.
19. Heine K, Heine H, Schmidt H: Zyklusabhängige Schwankungen im weißen blutbild gesunder frauen. Acta Biol Med Germ 1960;4:358-369.
20. MacKinnon IL: Observations on total leucocyte counts during thirteen consecutive human menstrual cycles. J Obstet Gynaecol Br Emp 1953;60:721-726.
21. Cruickshank JM, Morris R, Butt WR, Corker CS: Interrelationships between levels of plasma oestradiol, urinary total oestrogens and blood haemoglobin and neutrophil counts. J Obstet Gynaecol Br Emp 1972;79:450-454.
22. Cruickshank JM: The relationship of urinary total oestrogens with haemoglobin concentration. J Obstet Gynaecol Br Emp 1970;77:640-643.
23. Tyslowitz R, Dingemanse E: Effect of large doses of estrogens on the blood picture of dogs. Endocrinology 1941;29:817-827.
24. Crafts RC: The effects of endocrines on the formed elements of the blood: II. The effect of estrogens in the dog and monkey. Endocrinology 1941;29:606-618.
25. Shoenfeld Y, Alkan ML, Asaly A, et al: Benign familial leukopenia and neutropenia in different ethnic groups. Eur J Haematol 1988;41:273-277.
26. Reed WW, Diehl LF: Leukopenia, neutropenia, and reduced hemoglobin levels in healthy American blacks. Arch Intern Med 1991;151:501-505.
27. Rana SR, Castro OS, Haddy TB: Leukocyte counts in 7,739 healthy black persons: Effects of age and sex. Ann Clin Lab Sci 1985;15:51-54.