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Volumn 1, Issue 6, 2000, Pages 1203-1217

Current treatment of sepsis and endotoxaemia

Author keywords

Antimicrobial chemotherapy; Endotoxaemia; Phannacodynamics; Phannacokinetics; Sepsis; Septic shock

Indexed keywords

ANTIINFECTIVE AGENT;

EID: 0034280817     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.1.6.1203     Document Type: Article
Times cited : (20)

References (59)
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    • VINCENT J-L: New therapies in sepsis. Chest (1997) 112-.330S-338S. •None of the compounds investigated within new therapies for sepsis liave consistently improved the outcome because the research approach has been too narrowly focused. Attempts to completely block the sepsis response deprive the host of an essential defence mechanism.
    • New Therapies in Sepsis. Chest
    • Vincent, J.-L.1
  • 30
    • 0030747723 scopus 로고    scopus 로고
    • (1997) 9(SuppI. l):7-i-83.
    • GOULD IM: Pharmacodynamics and the relationship between in vitro and in vivo activity of antimicrobial agents./ Chemother. (1997) 9(SuppI. l):7-i-83. Optimal cidal activity of β-lactam antibiotics may be achieved only when all crucial heavy weight PBPs are saturated, which may be at concentrations approaching 100, or even 1000, times the MIC, depending on factors such as the inoculum and specific binding site preferences. At these concentrations, spheroplasts form and rapid bacterial cell lysis occurs. Depending on the antibiotic, these high concentration levels can be achieved in vivo for manyorganisms but only at higher doses than are normally administered.
    • Pharmacodynamics and the Relationship between in Vitro and in Vivo Activity of Antimicrobial Agents./ Chemother.
    • Gould, I.M.1
  • 46
    • 0032747599 scopus 로고    scopus 로고
    • (1999) 11(5):323-330.
    • PERITI P, NICOLETTI P: Classification of beta-lactam antibiotics according to their pharmacodynamics. J. Chemother. (1999) 11(5):323-330. Different affinities of β-lactam antibiotics for PBPs mayexplain the differences in grown bacterial patterns, suggesting three main responses to this kind of antimicrobial agents. Three classes of agents are delineated by the extent of PBP pattern saturation, bacterial biomass increase, PAE length and initial killing power. Some antibiotics do not liave the propensity to provoke septic shock because their mechanism of action is rapidly bactericidal, such as the carbapenems, the cephems ceftriaxone and cefepime, the glycopeptides, some aminoglycosides and fluoroquinolones.
    • NICOLETTI P: Classification of Beta-lactam Antibiotics According to Their Pharmacodynamics. J. Chemother.
    • Periti, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.