Clopidogrel-induced mixed hepatocellular and cholestatic liver injury

American Journal of Therapeutics

Volumn 7, Issue 5, 2000, Pages 317-318

  Willens, Howard J ^a,b,c  

^a MEMORIAL REGIONAL HOSPITAL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Clopidogrel; Drug induced hepatotoxicity

Indexed keywords

ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

AGED; ARTICLE; CASE REPORT; CHEMICALLY INDUCED DISORDER; CHOLESTASIS; DRUG EFFECT; FEMALE; HUMAN; LIVER; LIVER CELL; THROMBOCYTE AGGREGATION; TOXIC HEPATITIS;

AGED; AGED, 80 AND OVER; CHOLESTASIS; FEMALE; HEPATITIS, TOXIC; HEPATOCYTES; HUMANS; LIVER; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE;

EID: 0034278708     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200007050-00009     Document Type: Article

References (5)

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2. Moussa I, Oetgen M, Roubin G, et al: Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation 1999;99:2364-2366.
3. Savi P, Heilmann E, Nurden P, et al: Clopidogrel: an antithrombotic drug acting on the ADP-dependent activation pathway of human platelets. Clin Appl Thromb Hemost 1996;2:35-42.
4. Iqbal M, Goenka P, Young MF, et al: Ticlopidine-induced cholestatic hepatitis: report of three cases and review of the literature. Dig Dis Sci 1998;43:2223-2226.
5. Alvaro D, Gigliozzi A, Guadio E, et al: Ticlopidine-induced cholestasis: report of two cases and experimental evidence of the drug's adverse effect in isolated perfused rat liver. Eur J Gastroenterol Hepatol 1994;6:943-50.