Three-dimensional modeling to determine properties of tableting materials on rotary machines using a rotary tableting machine simulator

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 50, Issue 2, 2000, Pages 293-300

  Picker, Katharina M ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Compaction; Curve fitting; Data modeling; Rotary machine; Tablets

Indexed keywords

ARTICLE; PHARMACEUTICS; TABLET;

TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0034265889     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(00)00105-3     Document Type: Article

References (23)

1. R.W. Heckel, An analysis of powder compaction phenomena, Trans. Metall. Soc. AIME 221 (1961) 1001-1008.
2. R.W. Heckel, Density-pressure relationships in powder compaction, Trans. Metall. Soc. AIME 221 (1961) 671-675.
3. C. Fuehrer, Über den Druckverlauf bei der Tablettierung in Exzenterpressen, Dtsch. Apoth. Ztg. 102 (1962) 827-832.
4. M. Dürr, D. Hanssen, H. Harwalik, Kennzahlen zur Beurteilung der Verpreßbarkeit von Pulvern und Granulaten, Pharm. Ind. 34 (1972) 905-911.
5. H. Moldenhauer, H. Kala, G. Zessin, M. Dittgen, Zur pharmazeutischen Technologie der Tablettierung, Pharmazie 35 (1980) 714-726.
6. G. Ragnarsson, J. Sjogren, Force displacement measurements in tableting, J. Pharm. Pharmacol. 37 (1985) 145-150.
7. R. Dietrich, J.B. Mielck, Parametrisierung des zeitlichen Verlaufs der Verdichtung bei der Tablettierung mit Hilfe der modifizierten Weibull-Funktion, Pharm. Ind. 47 (1985) 216-220.
8. J.B. Mielck, G. Stark, Tableting of powder mixtures: Parameters of evolved pressure-time profiles indicate percolation thresholds during tableting, Eur. J. Pharm. Biopharm. 41 (1995) 206-214.
9. P.C. Schmidt, U. Tenter, Force and displacement characteristics of rotary tableting machines, Pharm. Ind. 49 (1987) 637-642.
10. P.C. Schmidt, U. Tenter, Presskraft-und Weg-Zeit-Charakteristik von Rundlauftablettenpressen, 3.Mitt.: Vergleich verschiedener Pressmaterialien, Pharm. Ind. 50 (1988) 376-381.
11. E.G. Rippie, D.W. Danielsson, Viscoelastic stress/strain behaviour of pharmaceutical tablets: analysis during unloading and postcompression periods, J. Pharm. Sci. 70 (1981) 476-482.
12. F. Müller, Viscoelastic models, in: G. Alderborn, C. Nyström (Eds.), Pharmaceutical Powder Compaction Technology, Marcel Dekker Inc, New York, 1995, pp. 99-132.
13. K.M. Picker, A new theoretical model to characterize the densification behavior of tableting materials, Eur. J. Pharm. Biopharm. 49 (2000) 267-273.
14. D.W. Danielson, W.T. Morehead, E.G. Rippie, Unloading and post-compression viscoeleastic stress versus strain behavior of pharmaceutical solids, J. Pharm. Sci. 72 (1983) 342-345.
15. C. Matz, A. Bauer-Brandl, T. Rigassi, R. Schubert, D. Becker, On the accuracy of a new displacement instrumentation for rotary tablet presses, Drug Dev. Ind. Pharm. 25 (1999) 117-130.
16. M. Levin, L. Tsygan, S. Dukler, Press simulation apparatus and methods, US Patent application No. 08/998,536 International Patent application No. PCT/US98/27421, filed December 23, 1998.
17. M. Levin, Theory and practice of tablet press simulation for process scale-up, Arden House Conference, January, 1999.
18. M. Celik, K. Marshall, Use of a compaction simulator system in tableting research, Drug Dev. Ind. Pharm. 15 (1989) 759-800.
19. S.D. Bateman, M.H. Rubinstein, R.C. Rowe, R.J. Roberts, P. Drew, A.Y.K. Ho, A comparative investigation on compression simulators, Int. J. Pharm. 49 (1989) 209-212.
20. S.D. Bateman, High speed compaction simulators in tabletting research, Pharm. J. 240 (1988) 632-633.
21. L.E. Holman, K. Marshall, Calibration of compaction simulator for the calibration of tablet thickness during compression, Pharm. Res. 10 (1993) 816-822.
22. C.D. Ruegger, An investigation of the effect of compaction profiles on the tableting properties of pharmaceutical substances, PhD Thesis, Rutgers University, 1996.
23. P. Konkel, J.B. Mielck, Associations of parameters characterizing the time course of the tableting process on a reciprocating and on rotary tableting machine for high-speed production, Eur. J. Pharm. Biopharm. 45 (1998) 137-148.