The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter

Blood

Volumn 96, Issue 3, 2000, Pages 1136-1143

  Gallagher, P G ^a   Romana, M ^a   Tse, W T ^a   Lux, S E ^a   Forget, B G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; BINDING PROTEIN; TRANSCRIPTION FACTOR GATA 1;

ARTICLE; BINDING SITE; CELL CULTURE; CELL LINE; CHRONIC MYELOID LEUKEMIA; DNA FOOTPRINTING; ERYTHROID CELL; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEREDITARY SPHEROCYTOSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; TRANSACTIVATION; TRANSCRIPTION INITIATION;

EID: 0034254592     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.1136     Document Type: Article

References (51)

1. Ankyrins: Adaptors between diverse plasma membrane proteins and the cytoplasm
2. Ankyrins: Structure and function in normal cells and hereditary spherocytes
3. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins
4. cDNA sequence for human erythrocyte ankyrin
5. Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes
6. Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain
7. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier
8. Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene
9. Structure and organization of the human ankyrin-1 gene: Basis for complexity of pre-mRNA processing
10. Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle
11. An alternative first exon in the distal end of the erythroid ankyrin gene leads to production of a small isoform containing an Nh2-terminal membrane anchor
12. An alternate promoter directs expression of a truncated, muscle- specific isoform on the human ankyrin 1 gene
13. Identification of a small cytoplasmic ankyrin (AnkG 119) in the kidney and muscle that binds beta I sigma spectdn and associates with the Golgi apparatus
14. Combined spectrin and ankyrin deficiency is common in autosomal dominant hereditary spherocytosis
15. Red cell membrane protein abnormalities in hereditary spherocytosis in Brazil
16. Red blood cell membrane disorders
17. Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis
18. Hematologically important mutations. Spectrin and ankyrin vadants in hereditary spherocytosis
19. A novel ankyrin promoter mutation associated with hereditay spherocytosis
20. DNA sequencing with chain-terminating inhibitors
21. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction
22. Assay of gene transcription in vivo
23. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligo-nucleotide primer
24. Oligodeoxyribo-nucleotide ligation to single-stranded cDNAs: A new tool for cloning 5' ends of mRNAs and for constructing cDNA libraries by in vitro amplification
25. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
26. A human beta-spectrin gene promoter directs high level expression in erythroid but not muscle or neural cells
27. Isolation and characterization of the cDNA encoding BKLF/ TEF-2, a major CACCC-box-binding protein in erythmid cells and selected other cells
28. Basic local alignment search tool
29. Chimeric 3-hydroxy-3-ethyiglutaryl coenzyme A reductase-dihydrofo-late reductase genes display bidirectional expression and unidirectional regulation in stably transfected cells
30. HMG CoA reductase: A negatively regulated gene with unusual promoter and 5' untranslated regions
31. Use of restriction enzymes to detect potential gene sequences in mammalian DNA
32. Alternative chromatin structure at CpG islands
33. Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene
34. Promoter-specific activation of RNA polymerase II transcription by Sp1
35. Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties
36. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1
37. Activation of the erythropoietin receptor promoter by transcription factor GATA-1
38. Analyses of beta-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell-specific transcription factor
39. Hematopoiesis: How does it happen?
40. Transcription factors and hematopoietic development
41. Erythroid-specific transcription
42. Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements
43. Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference
44. CCACC-binding or simian-virus-40-protein-1-binding proteins cooperate with human GATA-1 to direct erythroid-specific transcription and to mediate 5' hypersensitive site 2 sensitivity of a TATA-less promoter
45. Functional interaction of GATA1 with erythroid Kruppel-like factor and Sp1 at defined erythroid promoters
46. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF
47. The structural and functional diversity of dystrophin
48. The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria
49. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene