Prospectively validated prediction of organ failure and hypotension in patients with septic shock: The Systemic Mediator Associated Response Test (SMART)

Shock

Volumn 14, Issue 2, 2000, Pages 101-106

  Slotman, Gus J ^a,b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b Department of Surgery ^*  (United States)

Author keywords

Cytokines; Multiple organ failure; Prognostication; Sepsis; System inflammation

Indexed keywords

CYTOKINE;

AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL MODEL; BLOOD; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST; HOSPITALIZATION; HUMAN; HYPOTENSION; METHODOLOGY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PHASE 3 CLINICAL TRIAL; PREDICTION AND FORECASTING; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; ROC CURVE; SEPTIC SHOCK; STATISTICAL MODEL; VALIDATION STUDY;

AREA UNDER CURVE; COHORT STUDIES; CYTOKINES; DIAGNOSTIC TESTS, ROUTINE; HUMANS; HYPOTENSION; LINEAR MODELS; MODELS, BIOLOGICAL; MULTIPLE ORGAN FAILURE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT (HEALTH CARE); PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; ROC CURVE; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC;

EID: 0034243817     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200014020-00004     Document Type: Article

References (34)

1. Dominioni L, Dionigi R, Zanello M, et al: Sepsis score and acute-phase protein response as predictors of outcome in septic surgical patients. Arch Surg 122:141-146, 1987.
2. Marshall JC, Cook DJ, Christou NV, et al: Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638-1652, 1995.
3. Vincent JL, Moreno R., Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 22:707-710, 1996.
4. Lemeshow S, Teres D, Klar J, et al: Mortality probability models (MPM II) based on an international cohort of intensive care unit patients. JAMA 270:2478-2486, 1993.
5. Le Gall J, Lemeshow S, Saulnier F: A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957-2963, 1993.
6. Knaus WA, Wagner DP, Draper EA, et al: The APACHE III prognostic system: Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100:1619-1636, 1991.
7. Knaus WA, Harrell FE, Fisher CJ: The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis. JAMA 270: 1233-1241, 1993.
8. Seneff MG, Zimmerman JE, Knaus WA, et al: Predicting the duration of mechanical ventilation. The importance of disease and patient characteristics. Chest 110:469-479, 1996.
9. Meduri GU, Headley S, Kohler G, et al: Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1β and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 107:1062-1073, 1995.
10. Dinarello CA: Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 112:3218-329S, 1997.
11. Slotman GJ, Burchard KW, Yellin SA, et al: Prostaglandin and complement interaction in clinical acute respiratory failure. Arch Surg 121:271-274, 1986.
12. Slotman GJ, Quinn JV: Multivariate regression modeling for the prediction of inflammation, systemic pressure, and end-organ function in severe sepsis. Shock 8:225-231, 1997.
13. Slotman GJ, Quinn: Multivariate regression modeling for the prediction of plasma eicosanoid and cytokine concentrations in patients with severe sepsis. J Surgical Outcomes 1:24-30, 1998.
14. Fisher CJ, Dhainaut JFA, Opal SM, et al: Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. JAMA 271:1836-1843, 1999.
15. Afifi A, Clark C: Computer-aided Multivariate Analysis, 2 ed. New York: Van Nostrans and Reinhold Co., p. 179, 1990.
16. Kirkwood BR: Essentials and Medical Statistics. Oxford, UK: Blackwell Scientific Publications, 1988.
17. Hanley JA, McNeil BJ: The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143:29-36, 1982.
18. Sauaia A., Moore FA, Moore EE, et al: Early predictors of post-injury multiple organ failure. Arch Surg 129:39-45, 1994.
19. Sauaia A, Moore FA, Moore EE, et al: Multiple organ failure can be predicted as early as 12 hours after injury. J Trauma 45:291-303, 1998.
20. Osler TM, Rutledge R, Deis J, et al: ICISS: An International Classification of Disease-9 based Injury Severity Score. J Trauma 41:380-388, 1996.
21. Wagner DP, Knaus WA, Harrell FE, et al: Daily prognostic estimates for critically ill adults in intensive care units. Results from a prospective, multicenter, inception cohort analysis. Crit Care Med 22:1359-1372, 1994.
22. Millili JJ, Philiponis VS, Nusbaum M: Predicting surgical outcome using Bayesian analysis. J Surg Res 77:45-49, 1998.
23. Barie PS, Hydo LJ, Fischer E: Utility of illness severity scoring for prediction of prolonged surgical critical care. J Trauma 40:513-519, 1996.
24. Barie PS, Hydo LJ, Fischer E: Development of multiple organ dysfunction syndrome in critically ill patients with perforated viscus. Arch Surg 131: 37-13, 1996.
25. Sellers BJ, Davis BL, Larkin PW, et al: Early prediction of prolonged ventilator dependence in thermally injured patients. J Trauma 43:899-903, 1997.
26. Slotman GJ, Friedman B, Brathwaite C, et al: Interleukin-1 mediates increased plasma levels of eicosanoids and cytokines in patients with sepsis syndrome. Shock 4:318-323, 1995.
27. Pinsky MR, Vincent JL, Deviere J, et al: Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 103:565-575, 1993.
28. Miller EJ, Cohen AB, Matthay MA: Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med 24:1448-1454, 1996.
29. Függer R, Zadrobilek E, Götzinger P, et al: Perioperative TNFα and IL-6 concentrations correlate with septic state, organ function, and APACHE II scores in intra-abdominal infection. Eur J Surg 159:525-529, 1993.
30. Mitaka C, Hirata Y, Nagura T: Circulating endothelin-1 concentrations in acute respiratory failure. Chest 104:476-480, 1993.
31. Schlag G, Redl H: Mediators of injury and inflammation. World J Surg 20:406-110, 1996.
32. Boldt J, Wollbrück M, Kuhn D, et al: Do plasma levels of circulating soluble adhesion molecules differ between surviving and non-surviving critically III patients. Chest 107:787-792, 1995.
33. Nast-Kolb D, Waydhas C, Gippner-Steppert C, et al: Indicators of the post-traumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 42:446-155, 1997.
34. Parsons PE, Moss M, Vannice JL, et al: Circulating IL-1ra and IL-10 levels are increased but do not predict the development of acute respiratory distress syndrome in at-risk patients. Am J Respir Crit Care Med 155: 1469-1473, 1997.