Changes in pupil reaction to light in Alzheimer's disease patients: A preliminary report

International Journal of Psychophysiology

Volumn 37, Issue 1, 2000, Pages 111-120

  Fotiou, F ^a   Fountoulakis, K N ^b   Tsolaki, M ^c   Goulas, A ^b   Palikaras, A ^b  

^a Lab Clin Neurophysiol Gen H   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c G PAPANICOLAOU HOSPITAL   (Greece)

Author keywords

Acetylcholine; Alzheimer's disease; Autonomic nervous system; Dementia; Pupillometry

Indexed keywords

ACETYLCHOLINE; DONEPEZIL;

ALZHEIMER DISEASE; AUTONOMIC NERVOUS SYSTEM; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; MALE; MIOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PUPIL REFLEX; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; HUMANS; INDANS; LIGHT; PIPERIDINES; PUPIL; REACTION TIME; REFERENCE VALUES;

EID: 0034237780     PISSN: 01678760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8760(00)00099-4     Document Type: Conference Paper

References (54)

1. Altman D.G. Practical Statistics for Medical Research. 1991;Chapman and Hall, London.
2. Diagnostic and Statistical Manual of Mental Disorders, DSM-IV. 4th ed. 1994;American Psychiatric Association, Washington, DC.
3. Bakes A., Bradshaw C.M., Szabadi E. Attenuation of the pupillary light reflex in anxious patients. Br. J. Clin. Pharmacol. 30(3):1990;377-381.
4. Bourne M., Szabadi E., Bradshaw C.M. A comparison of the effects of single doses of amoxapine and amitriptyline on autonomic functions in healthy volunteers. Eur. J. Clin. Pharmacol. 44(1):1993;57-62.
5. Eustace P., Murnaghan S., Drury M.I. Pupil constriction to dilute pilocarpine: a useful clinical sign of autonomic involvement in diabetic neuropathy. Huber A., Klein D. Neurogenetics and Neuro-ophthalmology. 1981;247-250 North-Holland Biomedical Press, Amsterdam.
6. Feiler V., Inzelberg R., Korzcyn A.D. Cholinergic sensitivity of the pupil of demented Parkinson's disease patients. Neurology. A162:1996.
7. Folstein M.F., Folstein S.E., McHugh P.R. 'Mini-mental state': a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12:1974;189-198.
8. Fotiou F., Papakostopoulos D., Hamlatzis P. Changes in the pattern reversal visual evoked potentials in myasthenia gravis. Electromyogr. Clin. Neurophysiol. 34:1994;171-175.
9. Fotiou F., Goulas A., Fountoulakis K., Papakostopoulos D. Changes in psychophysiology of vision in myasthenia gravis. Int. J. Psychophysiol. 29:1998;303-310.
10. Fotiou F., Fountoulakis K., Tsolaki M., Tsorlinis H., Goulas A., Alexopoulos L. Changes in the pupil reaction to light in Alzheimer's disease patients. Int. J. Psychophysiol. 30:1998;159-160.
11. Fountoulakis K., Tsolaki M., Chantzi H., Kazis A. Mini-mental state examination. A validation study in elderly demented patients in Greece. Enkephalos (Greece). 31:1994;93-102.
12. Fountoulakis K., Tsolaki M., Mohs R.C., Kazis A. Epidemiological dementia index: a screening instrument for Alzheimer's disease and other types of dementia suitable for use in populations with low education level. Dement Geriatr. Cogn. Disord. 9:1998;329-338.
13. Fountoulakis K., Fotiou F., Iacovides A., Goulas A., Tsolaki M., Ierodiakonou Ch. Changes in pupil reaction to light in melancholic patients. Int. J. Psychophysiol. 31:1999;121-128.
14. Graff-Radford N., Lin S.C., Brazis P., Bolling J. Tropicamide eye drops in Alzheimer's disease patients and controls. Fifth International Conference on Alzheimer's Disease and Related Disorders, Osaka. Neurobiol Aging. 17(660):1996;S164.
15. Grunberger J., Linzmayer L., Majda E.M. et al. Receptor test (pupil dilation after application of 0.01% tropicamide solution) and determination of central nervous activation (Fourier analysis of pupillary oscillations) in patients with Alzheimer's disease and multiple sclerosis. Alzheimer's Disease 12th International Conference, Jerusalem, Israel. 1996.
16. Hamilton M. A rating scale for depression. Neurol. Neurosurg. Psychiat. 23:1960;56-62.
17. Hutchins J.B., Corbett J.J. The visual system. Haines D.E. Fundamental Neuroscience. 1997;265-284 Churchill Livingstone, New York.
18. Hutton T.J. Alzheimer's disease. Cohn's Current Therapy. 1990;780.
19. Idiaquez J., Alvarez G. et al. Cholinergic supersensitivity of the iris in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 57:1994;1544-1545.
20. Imamura Y., Kojima H., Haraoka K. Pupil dilation response to the acetylcholine receptor antagonist tropicamide in normal aged and senile dementia subjects. Fifth International Conference on Alzheimer's Disease and Related Disorders, Osaka. Neurobiol. Aging. 17(662):1996;S165.
21. Kaneyuki H., Mitsuno S., Furukawa Y. et al. Enhanced miotic response to topically administered dilute pilocarpine in patients with Alzheimer's disease. Neurobiol. Aging. 17(659):1996;S164.
22. Karacorlu M.A., Syrel Z., Cakiner T., Hanyaloglou E., Saylan T., Mat C. Pupil cycle time and early autonomic involvement in ocular leprosy. Br. J. Ophthalmol. 75:1991;45-48.
23. Katz B. Detecting Alzheimer's disease. Science. 267:1995;1578-1579.
24. Kono K., Miyao M., Ishihara S. et al. Do Alzheimer's patients have a hypertensive pupil dilation response to a cholinergic antagonist? Neurobiol. Aging. 17(664):1996;S165.
25. Kurz A., Marquard R., Fremke S., Leipert K.P. Pupil dilation response to tropicamide: a biological test for Alzheimer's disease? Pharmacopsychiatry. 30(1):1997;12-15.
26. Lanting P., Bos J.E., Aartsen J., Schuman L., Reichert-Thoen J., Heimans J.J. Assessment of pupillary light reflex latency and darkness adapted pupil size in control subjects and in diabetic patients with and without cardiovascular autonomic neuropathy. J. Neurol. Neurosurg. Psychiatry. 53(10):1990;912-914.
27. Leszek J., Gasiorowski K., Wojtowicz B. Pupil dilation by tropicamide in AD patients and probands. Neurobiol. Aging. 17(661):1996;S164-S165.
28. Loupe D.N., Newman N.J. et al. Pupillary response to tropicamide in patients with Alzheimer's disease. Ophthalmology. 103(3):1996;495-503.
29. Maclean H., Dhillon B. Pupil cycle time and human immunodeficiency virus (HIV) infection. Eye. 7:1993;785-787.
30. Marx J.L., Kumar S.R., Thach A.B., Winarko T.K., Frambach D.A. Detecting Alzheimer's disease. Science. 267:1995;1577-1578.
31. Matsushita S., Arai H., Hasegawwa Y. et al. Apolipoprotein E e4 allele and pupillary response to tropicamide in AD and cognitively normal subjects. Neurobiol. Aging. 17(754):1996;S165.
32. Newman J.N. Neuro-ophthalmology and systemic disease - part II. An annual review. J. Neuro-Ophthalmol. 15(4):1995;241-255.
33. Clinical diagnosis of Alzheimer's disease. Neurology. 34:1984;939-944.
34. Papakostopoulos D., Papakostopoulos S. Automated dynamic binocular pupillometry for clinical practice and research. Abstracts of the 7th International Congress of Psychophysiology of the IOP, 27 September-2 October, Thessaloniki, Greece. 1994.
35. Prettyman R., Bitsios P., Szabadi E. Altered pupillary size and darkness and light reflexes in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 62(6):1997;665-668.
36. Roth M., Tym E., Mountjoy C.Q., Huppert F.A. et al. CAMDEX: a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br. J. Psychiatry. 149:1986;698-709.
37. Roth M., Tym E., Mountjoy C.Q., Huppert F.A. CAMDEX: the Cambridge Examination for Mental Disorders of the Elderly. 1988;22 University Press, Cambridge.
38. Rubin A., Price L., Charney D., Heninger G. Noradrenergic function and the cortisol response to DST in depression. Psychiatry Res. 15:1985;5-15.
39. Sacks B., Smith S. People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction. J. Neurol. Neurosurg. Psychiatry. 52:1989;1294.
40. Scinto L.F.M., Daffner K.R., Dressler D. et al. A potential non-invasive neurobiological test for Alzheimer's disease. Science. 266:1994;1051-1054.
41. Scinto L.F.M., Daffner K.R., Dressler D. et al. A non-invasive peripheral nervous system test for Alzheimer's disease. Neurobiol. Aging. 15(Suppl. 1):1994;S92-S379.
42. Scinto L.F.M., Renz D., Vale F., Daffner K. Test retest reliability of the pupil assay for the diagnosis of Alzheimer's disease. Neurology. 46:1996;A161.
43. Scinto L.F.M., Rentz D., Cohen L., Preston L., Daffner K. Pupil dilation as an early marker for AD: longitudinal findings in elderly subjects. Neurobiol. Aging. 594:1996;S148.
44. Sheikh J.I., Yesavage J.A. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin. Gerontol. 5:1986;165-173.
45. Shur E., Checkley S. Pupil studies in depressed patients: an investigation of the mechanism of action of desipramine. Br. J. Psychiatry. 140:1982;181-184.
46. Sokolski K.N., DeMet E.M. Increased pupillary sensitivity to pilocarpine in depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 20(2):1996;253-262.
47. Szabadi E., Gaszner P., Bradshaw C.M. The peripheral anticholinergic activity of tricyclic antidepressants: comparison of amitriptyline and desipramine in human volunteers. Br. J. Psychiatry. 137:1980;433-439.
48. Theofilopoulos N., McDade G., Szabadi E., Bradshaw C.M. Effects of reboxetine and desipramine on the kinetics of the pupillary light reflex. Br. J. Clin. Pharmacol. 39(3):1995;251-255.
49. Treloar A., Assin M., Macdonald A. Detecting Alzheimer's disease. Science. 267:1995;1578.
50. Tsolaki M., Fountoulakis K., Chantzi H., Kazis A. The Cambridge cognitive examination (CAMCOG) - a validation study in elderly demented patients in Greece. Enkephalos (Greece). 33:1996;57-77.
51. Tsolaki M., Fountoulakis K., Pavlopoulos I., Chatzi E., Kazis A. Prevalence of Alzheimer's disease and other dementing disorders in Pilea, Greece. Neurobiol. Aging. 378:1996;S94-S95.
52. Tsolaki M., Fountoulakis K., Chantzi H., Kazis A. Risk factors for clinically diagnosed Alzheimer's disease: a case control study in a Greek elderly population. Int. Psychogeriatr. 9(3):1997;327-341.
53. Tsolaki M., Reptsis A., Zafiriou D., Zissiades K., Kazis A. Is cholinergic sensitivity of the pupil of patients with Alzheimer's disease different from other dementias? Alzheimer's Res. 3:1997;105-108.
54. Yesavage J.A. Depression in the elderly: how to recognize masked symptoms and choose appropriate therapy. Postgrad. Med. 91:1992;255-261.