Three-dimensional modelling of the catalytic domain of Streptococcus mutans glucosyltransferase GtfB

FEMS Microbiology Letters

Volumn 188, Issue 1, 2000, Pages 75-79

  Tsai, Yau Wei ^a   Chia, Jean Shan ^a   Shiau, Yuh Yuan ^a   Chou, Hsiu Chuan ^a   Liaw, Yen Chywan ^b   Lou, Kuo Long ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

Catalytic domain; Glucosyltransferase; Streptococcus mutans; Sucrase activity; Three dimensional model; Tim barrel

Indexed keywords

GLUCOSYLTRANSFERASE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; GENETIC PROCEDURES; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STREPTOCOCCUS MUTANS; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; GLUCOSYLTRANSFERASES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STREPTOCOCCUS MUTANS; SUCROSE;

STREPTOCOCCUS MUTANS;

EID: 0034237711     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(00)00213-5     Document Type: Article

References (22)

1. Hamada, S. and Slade, H.D. (1980) Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol. Rev. 44, 331-384.
2. Monchois, V., Willemot, R.-M. and Monsan, P. (1999) Glucansucrases: mechanism of action and structure-function relationships. FEMS Microbiol. Rev. 23, 131-151.
3. Loesche, W.J. (1986) Role of Streptococcus mutans in human dental decay. Microbiol. Rev. 50, 353-380.
4. Honda, O., Kato, C. and Kuramitsu, H.K. (1990) Nucleotide sequence of the Streptococcus mutans gtfD gene encoding the glucosyltransferase-S enzyme. J. Gen. Microbiol. 136, 2099-2105.
5. Shiroza, T., Ueda, S. and Kuramitsu, H.K. (1987) Sequence analysis of the gtfB gene from Streptococcus mutans. J. Bacteriol. 169, 4263-4270.
6. Ueda, S., Shiroza, T. and Kuramitsu, H.K. (1988) Sequence analysis of the gtfC gene from Streptococcus mutans GS-5. Gene 69, 101-109.
7. Fujiwara, T., Tamesada, M., Bian, Z., Kawabata, S., Kimura, S. and Hamada, S. (1996) Deletion and reintroduction of glucosyltransferase genes of Streptococcus mutans and role of their gene products in sucrose dependent cellular adherence. Microb. Pathol. 20, 225-233.
8. Lis, M., Shiroza, T. and Kuramitsu, H.K. (1995) Role of C-terminal direct repeating units of the Streptococcus mutans glucosyltransferase-S in glucan binding. Appl. Environ. Microbiol. 61, 2040-2042.
9. Nakano, Y.J. and Kuramitsu, H.K. (1992) Mechanism of Streptococcus mutans glucosyltransferases: hybrid-enzyme analysis. J. Bacteriol. 174, 5639-5646.
10. Mooser, G., Hefta, S.A., Paxton, R.J., Shively, J.E. and Lee, T.D. (1991) Isolation and sequence of an active-site peptide containing a catalytic aspartic acid from two Streptococcus sobrinus alpha-glucosyltransferases. J. Biol. Chem. 266, 8916-8922.
11. Kato, C., Nakano, Y., Lis, M. and Kuramitsu, H.K. (1992) Molecular genetic analysis of the catalytic site of Streptococcus mutans glucosyltransferases. Biochem. Biophys. Res. Commun. 189, 1184-1188.
12. Devulapalle, K.S., Goodman, S.D., Gao, Q., Hemsley, A. and Mooser, G. (1997) Knowledge-base model of glucosyltransferase from the oral bacteria group of mutans streptococci. Prot. Sci. 6, 2489-2493.
13. Chia, J.-S., Lin, S.-W., Yang, C.-S. and Chen, J.-Y. (1997) Antigenicity of a synthetic peptide from glucosyltransferases of Streptococcus mutans in humans. Infect. Immun. 65, 1126-1130.
14. Funane, K., Shiraiwa, M., Hashimoto, K., Ichishima, E. and Kobayashi, M. (1993) An active-site peptide containing the second essential carboxyl group of dextransucrase from Leuconostoc mesenteroides by chemical modifications. Biochemistry 32, 13696-13702.
15. Chia, J.-S., Yang, C.-S. and Chen, J.-Y. (1998) Functional analyses of a conserved region in glucosyltransferases of Streptococcus mutans. Infect. Immun. 66, 4797-4803.
16. Monchois, V., Lakey, J.H. and Russell, R.R. (1999) Secondary structure of Streptococcus downei GTF-I glucansucrase. FEMS Microbiol. Lett. 177, 243-248.
17. Machius, M., Wiegand, G. and Huber, R. (1995) Crystal structure of calcium-depleted Bacillus licheniformis alpha-amylase at 2.2 Å resolution. J. Mol. Biol. 246, 545-559.
18. Hwang, K.Y., Song, H.K., Chang, C., Lee, J., Lee, S.Y., Kim, K.K., Choe, S., Sweet, R.M. and Suh, S.W. (1997) Crystal structure of thermostable alpha-amylase from Bacillus licheniformis refined at 1.7 Å resolution. Mol. Cells 7, 251-258.
19. Siezen, R.J., Rollema, H.S., Kuipers, O.P. and de Vos, W.M. (1995) Homology modelling of the Lactococcus lactis leader peptidase NisP and its interaction with the precursor of the lantibiotic nisin. Prot. Eng. 8, 117-125.
20. 8-barrel domain and evolutionary relationship to other amylolytic enzymes. J. Prot. Chem. 12, 791-805.
21. MacGregor, E.A., Jespersen, H.M. and Svensson, B. (1996) A circularly permuted alpha-amylase-type alpha/beta-barrel structure in glucan-synthesizing glucosyl-transferases. FEBS Lett. 378, 263-266.
22. Chia, J.-S., Lin, R.-H., Lin, S.-W., Chen, J.-Y. and Yang, C.-S. (1993) Inhibition of glucosyltransferase activities of Streptococcus mutans by a monoclonal antibody to a subsequence peptide. Infect. Immun. 61, 4689-4695.