Assignment of enzyme substrate specificity by principal component analysis of aligned protein sequences: An experimental test using DNA glycosylase homologs

Proteins: Structure, Function and Genetics

Volumn 40, Issue 1, 2000, Pages 98-105

  Gogos, Arhonda ^a   Jantz, Derek ^a   Sentürker, Sema ^b,d   Richardson, Delwood ^c   Dizdaroglu, Miral ^b   Clarke, Neil D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^c Institute for Genome Research   (United States)

^d CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

DNA glycosylase; Genome annotation; Principal component analysis; Substrate specificity

Indexed keywords

DNA GLYCOSYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; MOLECULAR CLONING; PHYLOGENY; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CONSENSUS SEQUENCE; DNA GLYCOSYLASES; EVOLUTION, MOLECULAR; HUMANS; MARKOV CHAINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-GLYCOSYL HYDROLASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0034237699     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(20000701)40:1<98::AID-PROT110>3.0.CO;2-S     Document Type: Article

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