Morphological and functional variations of Leydig cells in testis of the domestic pig during the different biological stages of development

Journal of Experimental Zoology

Volumn 287, Issue 2, 2000, Pages 167-175

  Tripepi, Sandro ^a   Carelli, Antonio ^a   Perrotta, Enrico ^a   Brunelli, Elvira ^a   Tavolaro, Renata ^a   Facciolo, Rosa Maria ^a   Canonaco, Marcello ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; METRIBOLONE; TESTOSTERONE RECEPTOR;

AGE DISTRIBUTION; ANIMAL; ARTICLE; BINDING SITE; CELL COUNT; CELL SIZE; CYTOLOGY; GROWTH, DEVELOPMENT AND AGING; LEYDIG CELL; MALE; METABOLISM; PHYSIOLOGY; SWINE; TESTIS;

AGE DISTRIBUTION; ANIMALS; BINDING SITES; CELL COUNT; CELL SIZE; LEYDIG CELLS; MALE; METRIBOLONE; RECEPTORS, ANDROGEN; SWINE; TESTIS;

ANIMALIA; SUS SCROFA; SUS SCROFA DOMESTICA;

EID: 0034235530     PISSN: 0022104X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-010X(20000701)287:2<167::AID-JEZ7>3.0.CO;2-3     Document Type: Article

References (33)

1. Andreis PG, Cavallini L, Malendowicz LK, Belloni AS, Rebuffat P, Mazzocchi G, Nussdorfer CG. 1989. Morphological and functional responses of rat Leydig cells to prolonged treatment with human chorionic gonadotropins. J Submicrosc Cytol Pathol 21:703-711.
2. Andresen O. 1976. Concentration of fat and plasma 5α-androstenone and plasma testosterone in boars selected for rate of body weight gain and thickness of backfat during growth, sexual maturation and after mating. J Reprod Fertil 48:51-59.
3. Bortolussi M, Zanchetta R, Belvedere P, Colombo L. 1990. Sertoli and Leydig cell numbers and gonadotropin receptors in rat testis from birth to puberty. Cell Tissue Res 260:185-191.
4. Bradford MM. 1976. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle protein-dye binding. Anal Biochem 72:248-254.
5. Bremner WJ, Millar MR, Sharpe RM, Saunders PTK. 1994. Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage dependent expression and regulation by androgens. Endocrinology 135:1227-1234.
6. Christensen AK. 1975. Leydig cells. Handbook Physiol Endocrinol 5:57-94.
7. Ewing LL, Zirkin BR, Cochran RC, Kromann N, Peters C, Ruiz-Bravo N. 1979. Testosterone secretion by rat, rabbit, guinea pig, dog, and hamster testes perfused in vivo: correlation with Leydig cell mass. Endocrinology 105:1135-1142.
8. Fawcett DW, Neaves WB, Flores MN. 1973. Comparative observations on intertubular lymphatics and the organization of the interstitial tissue of the mammalian testis sperm. Biol Reprod 9:500-532
9. Hardy MP, Kelec WR, Klinefelter GR, Ewing LL .1990. Differentiation of Leydig cell precursors in vitro: a role for androgen. Endocrinology 127:488-490.
10. Hardy MP, Gelber SJ, Zhou Z, Penning TM, Riciglian JW, Ganjam VK, Nonneman D, Ewing LL. 1991. Hormonal control of Leydig cell differentiation. Ann N Y Acad Sci 637:152-163.
11. Hardy MP, Kirby JD, Hess RA, Cooke PS. 1993. Leydig cells increased their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology 132:2417-2420.
12. Ichihara I, Kawamura H, Pelliniemi LJ. 1993. Ultrastructure and morphometry of testicular Leydig cells and the interstitial components correlated with testosterone in aging rats. Cell Tissue Res 271:241-255.
13. Keel BA, Abney TO. 1985. Oestrogenic regulation of testicular androgen production during development in the rat. J Endocrinol 105:211-218.
14. Keeney DS, Ewing LL. 1990. Effects of hypophysectomy and alterations in spermatogenic function on Leydig cell volume, number, and proliferation in adult rats. J Androl 11:367-378.
15. Kormano M, Suoranta H. 1971. Microvascular organization of the adult human testis. Anat Rec 170:31-40.
16. Lin T, Murono E, Osterman J, Allen DO, Nankin HR. 1980. The aging Leydig cell, 1: testosterone and adenosin 3′,5′-monophosphate responses to gonadotropin stimulation in rats. Steroids 35:653-663.
17. Maddocks S, Sowerbutts SF, Setchell BP. 1987. Effects of repeated injections of human chorionic gonadotropin on vascular permeability, extracellular fluid volume and the flow of lymph in the testes of rats. Int J Androl 10:535-542.
18. Mendis-Handagama SMLC, Zirkin BR, Ewing LL. 1988. Comparison of components of the testis interstitium with testosterone secretion in hamster, rat and guinea pig testes perfused in vitro. Am J Anat 181:12-22.
19. Mendis-Handagama SMLC, Zirkin BR, Scallen TJ, Ewing LL. 1990. Studies on perioxisomes of the adult rat Leydig cell. J Androl 11:270-278.
20. Mori H, Christensen AK. 1980. Morphometric analysis of Leydig cells in the normal rat testis. J Cell Biol 84:340-354.
21. Namiki M, Yokokawa K, Okuyama A, Koh E, Kiyohara H, Nakao M, Sakoda S, Matsumoto K, Sonoda T. 1991. Evidence for the presence of androgen receptors in human Leydig cells. J Steroid Biochem Mol Biol 38:79-82.
22. Patterson RLS. 1968. 5a-androst-16-ene-3-one, compound responsible for taint in boar fat. J Sci Food Agricult 19:31-38.
23. Raeside JI, Renaud RL, Friendship RM. 1989. Aromatization of 19-nor-androgens by porcine Leydig cells. J Steroid Biochem 32:729-735.
24. Raeside JI, Renaud RL, Friendship RM, Khalil MW. 1993. Secretion of 19-hydroxyandrostenedione and 19-hydroxytestosterone by porcine Leydig cells in vitro and in vivo. J Endocrinol 137:281-289.
25. Reinke F. 1896. Beiträge zur histologie des Menschem. Arch Mikr Anat 47:34-44.
26. 14C metabolism by rat seminferous tubules at different stages of development: formation of 3 α-androstanediol at meiosis. Endocrinology 91:537-544.
27. Saez JM, Sanchez P, Berthelon MC, Avallet O. 1989. Regulation of pig Leydig cell aromatase activity by gonadotropins and Sertoli cells. Biol Reprod 41:813-820.
28. Shan LX, Hardy DO, Catterall JF, Hardy MP. 1995. Effects of luteinizing hormone (LH) and androgen on steady state levels of messenger ribonuclei acid for LH receptors, androgen receptors, and steroidogenic enzymes in rat Leydig cell progenitors in vivo. Endocrinology 136: 1686-1693.
29. Teerds KJ, Closset J, Rommerts FFG, deRooij DG, Stocco DM, Colenbrander B, Wensing CJG, Hennen G. 1989. Effects of pure FSH and LH preparations on the number and function of Leydig cells in immature hypophysectomized rats. J Endocrinol 120:97-106.
30. Vornberger W, Prins G, Musto NA, Suarez-Quian CA. 1994. Androgen receptor distribution in rat testis: new implication for androgen regulation of spermatogenesis. Endocrinology 134:2307-2316.
31. Winters SJ, Troen P. 1984. Evidence for an androgen receptor in the seminiferous tubules of the human testis. J Steroid Biochem 21:315-320.
32. Wrobel KH, Reichold J, Schimmel M. 1995. Quantitative morphology of the ovine seminiferous epithelium. Ann Anat 177:19-32.
33. Zirkin BR, Ewing LL, Kromann N, Cochran RC. 1980. Testosterone secretion by rat, rabbit, guinea pig, dog and hamster testes perfused in vitro: correlation with Leydig cell ultrastructure. Endocrinology 107:1867-1874.