Evaluation of spinning disk reactor technology for the manufacture of pharmaceuticals

Industrial and Engineering Chemistry Research

Volumn 39, Issue 7, 2000, Pages 2175-2182

  Oxley, Paul ^a   Brechtelsbauer, Clemens ^a   Ricard, Francois ^a   Lewis, Norman ^a   Ramshaw, Colin ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DRUG PRODUCTS; LIQUIDS; MASS TRANSFER; PARTICLE SIZE ANALYSIS; REACTION KINETICS; THIN FILMS;

BATCH PROCESSES; PHASE TRANSFER CATALYZED DARZEN REACTION; SPINNING DISK REACTOR;

CHEMICAL REACTORS;

ARTICLE; CHEMICAL ENGINEERING; DRUG INDUSTRY; HEAT TRANSFER; REACTOR; TECHNOLOGY;

EID: 0034234899     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie990869u     Document Type: Article

References (15)

1. Jachuk, R. J.; Ramshaw, C.; Boodhoo, K.; Dalgleish, J. C. Process Intensification: The Opportunity Presented by Spinning Disc Reactor Technology. Inst. Chem. Eng. Symp. Ser. 1997, 141, 417-424.
2. Fell, N.; Ramshaw, C. Innovation Offers a New Spin on Drug Production. TCE 1997, 656, 23-25.
3. Saw, C. B.; Anderson, G. K.; Howarth, C. R.; Porter, J. E. Application of the Spinning Disc Reactor as an Ozone Contactor. Proc. Ind. Waste Conf. 1985, 40, 813-823.
4. Boodhoo, K. Process Intensification: Spinning Disc Reactor for Styrene Polymerisation. Ph.D. Thesis, Newcastle University, Newcastle, 1999.
5. Oxley, P.; Brechtelsbauer, C. Patent Application UK9920152.7.
6. Mahajan, A. J.; Kirwan, D. J. Rapid Precipitation of Biochemicals. J. Phys. D: Appl. Phys. 1993, 26 (8B), B176-B180.
7. Schmitt, W. J. Preparation of Finely Divided Solid Crystalline Powders via Precipitation into an Antisolvent. PCT Int. Appl. WO 9003782 A2 900419, 1990.
8. Uusipenttila, M.; Berglund, K. A. Spectroscopic Monitoring of Environmentally Benign Anti-solvent Crystallization, J. Crystal Growth 1996, 186 (1-4), 967-970.
9. Therminol 59 Thermodynamic Properties Datasheet, Solutia Inc., 1999, http://www.solutia.com/therminol/therm59.html.
10. Dowcal 10 Physical Properties Datasheet, Dow Chemical Co., 1999, http://www.dow.com.
11. 6
12. 5
13. 4
14. Naik, S. D.; Doraiswamy, L. K. Phase Transfer Catalysis: Chemistry and Engineering. AIChE J. 1998, 44 (3), 612-646.
15. 2