Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling

Journal of Surgical Research

Volumn 92, Issue 1, 2000, Pages 23-28

  Hines, Oscar J ^a   Ryder, Nova ^a   Chu, Jason ^a   McFadden, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDIC ACID;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MIGRATION; CELL STIMULATION; CYTOSKELETON; DRUG EFFECT; EPITHELIUM CELL; EXTRACELLULAR MATRIX; INTESTINE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RAT; SECOND MESSENGER; WOUND HEALING;

EID: 0034234648     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2000.5941     Document Type: Article

References (17)

1. Feil W., Wenzl E., Vattay P., Starlinger M., Sogukoglu T., Schiessel R. Repair of rabbit duodenal mucosa after acid injury in vivo and in vitro. Gastroenterology. 92:1987;1973.
2. Lacy E. R. Epithelial restitution in the gastrointestinal tract. J. Clin. Gastroenterol. 10:1988;72.
3. Silen W. Gastric mucosal defense and repair. Johson L. R. Physiology of the Gastrointestinal Tract. 1987;1055-1069 Raven Press, New York.
4. Nusrat A., Delp C., Madara J. L. Intestinal epithelial restitution: characterization of a cell model and mapping of cytoskeletal elements in migrating cells. J. Clin. Invest. 89:1992;1501.
5. Dignass A. U., Podolsky D. K. Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor B. Gastroenterology. 105:1993;1323.
6. Goke M., Zuk A., Podolsky D. K. Regulation and function of extracellular matrix in intestinal epithelial restitution in vitro. Am. J. Physiol. 271:1996;G729.
7. Goke M., Knai M., Lynch-Devaney K., Podolsky D. K. Rapid mitogen-activated protein kinase activation by transforming growth factor alpha in wounded rat intestinal epithelial cells. Gastroenterology. 114:1998;697.
8. Eichholtz T. K., Jalink I., Fahrenfort I., Moolenaar W. H. The bioactive phospholipid lysophophatidic acid is released from activated platelets. Biochem. J. 291:1993;677.
9. Moolenaar W. H., Kranenburg O., Postma F. R., Zondag G. C. Lysophosphatidic acid: G-protein signalling and cellular responses. Curr. Opin. Cell Biol. 9:1997;168.
10. Moolenaar W. H. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem. J. 281:1992;163.
11. Ridley A. J., Hall A. The small GTP-binding rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 70:1992;389.
12. Imamura F., Horai T., Mukai M., Shinkai K., Sawada M., Akedo H. Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D. Biochem. Biophys. Res. Commun. 193:1994;497.
13. Jalink K., Moolenaar W. H., Van Duijn B. Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae. Proc. Natl. Acad. Sci. USA. 90:1993;1857.
14. McCormack S. A., Viar M. J., Johnson L. R. Migration of IEC-6 cells: A model for mucosal healing. Am. J. Physiol. 263:1992;G426.
15. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440.
16. Hanks S. K., Calalb M. B., Harper M. C., Patel S. K. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA. 89:1992;8487.
17. Strum A., Sudermann T., Schulte K. M., Goebell H., Dignass A. U. Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid. Gastroenterology. 117:1999;368.