Effect of three structurally related antimalarial drugs on liver microsomal components and lipid peroxidation in rats

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 126, Issue 3, 2000, Pages 217-224

  Farombi, E Olatunde ^a   Olowu, Babatunde I ^a   Emerole, Godwin O ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Amodiaquine; Antimalarials; Drug oxidation; Glutathione; Halofantrine; Lipid peroxidation; Mefloquine; Microsomal lipids; Oxidative stress; Structure

Indexed keywords

4 NITROANISOLE DEMETHYLASE; AMODIAQUINE; ANTIMALARIAL AGENT; CHOLESTEROL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HALOFANTRINE; HEXOBARBITAL; MALONALDEHYDE; MEFLOQUINE; PENTOXYRESORUFIN DEALKYLASE; PHOSPHOLIPID; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG OXIDATION; LIPID PEROXIDATION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SLEEP TIME;

EID: 0034233459     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(00)00116-X     Document Type: Article

References (34)

1. Aniya Y., Naito A. Oxidative stress-induced activation of microsomal glutathione S-transferase in isolated rat liver. Biochem. Pharmacol. 45:1993;37-42.
2. Back D.J., Purba H.S., Stager C., Orme M.E.M., Breckenridge A.M. Inhibition of drug metabolism by the antimalarial drugs: chloroquine and primaquine in the rat. Biochem. Pharmacol. 32:1983;257-263.
3. Bartlett G.R. Assay of inorganic orthophosphate. J. Biol. Chem. 234:1959;466-468.
4. Bhattcharyya B., Chatterjee T.P., Ghosh J.J. Effects of chloroquine on lysosomal enzymes. NADPH-induced lipid peroxidation and antioxidant enzymes of rat retina. Biochem. Pharmacol. 42:1983;2965-2968.
5. Bray P.G., Ward S.A. Malaria containing drugs in Plasmodium falciparum. FEMS Microbiol. Lett. 113:1993;1-8.
6. Bruce-Chwatt L.J. Chemotherapy and chemoprophylaxis. Bruce-Chwatt L.J. Essential Malariology. second ed. 1985;210-260 Alden Press, Oxford.
7. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 52:1978;302-310.
8. Emerole G.O., Thabrew M.I. Changes in some rat hepatic microsomal components induced by prolonged administration of chloroquine. Biochem. Pharmacol. 32:1983;3005-3009.
9. Farombi E.O., Emerole G.O. Interference of common antimalarial drugs with some hepatic microsomal components and drug metabolism: potential implications for toxicity. South Afr. J. Sci. 94:1998;303-304.
10. Folch J., Lees M., Slone-Stanley G.H.S. Simple method for the estimation and purification of total lipid from animal tissues. J. Biol. Chem. 226:1957;497-509.
11. Gibson G.G., Skett P. Introduction to Drug Metabolism. second ed. 1995;217-258 Blackie, Chapman and Hall, London.
12. Guo Z., Smith T.J., Wang E., Sadrieh N., Ma Q., Thomas P.E., Yang C.S. Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. Carcinogenesis. 13:1992;2205-2210.
13. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferase. The first enzymic step in mercapturic acid formation. J. Biol. Chem. 249:1974;7130-7139.
14. Halliday R.C., Jones B.C., Smith D., Kitteringham N.W., Park B.V. An investigation of the interaction between halofantrine, CYP2D6 and CYP3N4: studies with human liver microsomes and heterologous enzyme expression systems. Br. J. Clin. Pharmacol. 40:1995;369-378.
15. Ignatuschchenko M.V., Winter R.W., Bachingeo H.P., Hinrichs D.J., Riscoe M.K. Xanthones as antimalarial agents: studies of a possible mode of action. FEBS Lett. 409:1997;67-73.
16. Jollow D.J., Mitchell J.R., Zampaglione N., Gillette J.R. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 11:1974;151-169.
17. Leo, K.U., Wesche, D.L., Marino, M.T., Brewer, T.G., 1996. Mefloquine effect on deposition of halofantrine in the isolated perfused rat liver. J. Pharm. Pharmacol. 48,
18. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
19. Lu A.Y.H., Junk K.W., Coon M.J. Resolution of the cytochrome P-450 containing co-hydroxylation system of liver microsomes into three components. J. Biol. Chem. 244:1969;3714-3721.
20. Milton K.A., Edwards G., Ward S.A., Orme M.L.E., Breckenridge A.M. Pharmacokinetics of halofantrine in maneffects of food and dose size. Br. J. Clin. Pharmacol. 28:1989;71-77.
21. Milton K., Hoakseu P.E., Ward S.A., Edwards G. Lack of effect of halofantrine on hepatic drug metabolism in the rat in vivo and in vitro. Biochem. Pharmacol. 39:1990;1581-1586.
22. Murray M. In vitro effects of quinoline derivatives on cytochrome P450 aminopyrine N-demethylase activity in rat hepatic microsomes. Biochem. Pharmacol. 34:1984;567-571.
23. Murray M. Mechanisms of the inhibition of cytochrome P-450-mediated drug oxidation by therapeutic agents. Drug Metab. Rev. 18:1987;55-81.
24. Reiners J.J., Cantu A.R., Pavone A., Smith S.C., Gardner C.R., Laskin D.L. Fluorescence assay for per-cell estimation of cytochrome P-450 dependent monooxygenase activities in keratinocyte suspensions and cultures. Anal. Biochem. 188:1995;1973-1978.
25. Riviere T.H., Back D.J. Effect of mefloquine on drug metabolism in rat. Comparative study with primaquine. Biochem. Pharmacol. 34:1985;567-571.
26. Rudel L.L., Morris M.D. Determination of cholesterol using O-phthaldehyde. J. Lipid Res. 14:1973;364.
27. Schinitzky M., Inbar M. Micro viscosity parameters and protein mobility in biological membranes. Biochem. Biophys. Acta. 433:1976;133-149.
28. Sukhumanan J., Suphakawanick W., Thithapanila A. Comparative inhibitory effects of mefloquine and primaquine on hepatic drug metabolizing enzymes. Biochem. Pharmacol. 39:1990;212-216.
29. Ward S.A., Park B.K. The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse. J. Pharmacol. Exp. Ther. 273:1995;393-404.
30. Wendel, Feuerstein S., Kong K. Acute paracetamol intoxication of starved mice leads to lipid peroxidarion in vivo. Biochem. Pharmacol. 28:1979;2051-2055.
31. Wernsdorfer W.H. The development and spread of drug-resistance malaria. Parasitol. Today. 7:1991;297-303.
32. Winter R.W., Cornell K.A., Johnson L.L., Igntushchenko M., Kinrichs D.J., Riscoe M.K. Potentiation of the antimalarial agent rufigallol. Antimicrob. Agents Chemother. 40:1996;1408-1414.
33. World Health Organization Malaria Unit Bull. WHO. 71:1993;281-284.
34. Zidovetzki R., Sherman I.W., Cardenas M., Borchardt D.B. Chloroquine stabilization of phospholipid membranes against diacylglycerol-induced perturbation. Biochem. Pharmacol. 45:1993;183-189.