Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid

Free Radical Biology and Medicine

Volumn 29, Issue 1, 2000, Pages 79-89

  Hwang, Juliana ^a   Sevanian, Alex ^a   Hodis, Howard N ^a   Ursini, Fulvio ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antioxidant; ApoB 100; Copper; Daidzein; Equol; Free radicals; Genistein; Lipid peroxidation

Indexed keywords

ASCORBIC ACID; DAIDZEIN; EQUOL; GENISTEIN; LOW DENSITY LIPOPROTEIN; PEROXY RADICAL; PHYTOESTROGEN; SCAVENGER;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; ESTROGEN THERAPY; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; LIPID PEROXIDATION; MENOPAUSE; OXIDATION; PRIORITY JOURNAL;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; CHROMANS; DRUG SYNERGISM; ESTROGENS, NON-STEROIDAL; FEMALE; GENISTEIN; HUMANS; ISOFLAVONES; KINETICS; LIPID PEROXIDATION; LIPID PEROXIDES; LIPOPROTEINS, LDL; MALE; OXIDATION-REDUCTION; PHYTOESTROGENS; PLANT PREPARATIONS;

EID: 0034233051     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00322-1     Document Type: Article

References (39)

1. Coronary Drug Project Research Group. Coronary Drug Project: Colfibrate and Niacin in Coronary Heart Disease. JAMA 231:360-381; 1975.
2. Adlercreutz H., Mazur W. Phyto-estrogens and western diseases. Ann. Med. 29:1997;95-120.
3. Tikkanen M.J., Wahala K., Ojala S., Vihma V., Adlercreutz H. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc. Natl. Acad. Sci. USA. 95:1998;3106-3110.
4. Dubey R.K., Gillespie D.G., Imthurn B., Rosselli M., Jackson E.K., Keller P.J. Phytoestrogens inhibit growth and MAP kinase activity in human aortic smooth muscle cells. Hypertension. 33:1999;177-182.
5. Wang T.T., Sathyamoorthy N., Phang J.M. Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis. 17:1996;271-275.
6. Zhou Y., Lee A.S. Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy. J. Natl. Cancer Inst. 90:1998;381-388.
7. Kapiotis S., Hermann M., Held I., Seelos C., Ehringer H., Gmeiner B.M.K. Genistein, the dietary-derived angiogenesis ionhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscler. Thromb. Vasc. Biol. 17:1997;2868-2874.
8. Ruiz-Larrea M.B., Mohan A.R., Paganga G., Miller N.J., Bolwell G.P., Rice-Evans C.A. Antioxidant activity of phytoestrogenic isoflavones. Free Radic. Biol. Med. 26:1997;63-70.
9. Akiyama T., Ishida J., Nakagava S., Ogawara S., Watanabe S., Itoh N., Shiyba M., Fukami Y. Genistein, aspecific inhibitor of tyrosine-specific protein kinase. J. Biol. Chem. 262:1987;5592-5595.
10. Kurzer M.S., Xu X. Dietary phytoestrogen. Annu. Rev. Nutr. 17:1997;353-381.
11. Morton M.S., Wilcox G., Wahlqvist M.L., Griffiths K. Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. J. Endocrinol. 142:1994;251-259.
12. Kelley G.E., Joannou G.E., Reeder A.Y., Nelson C., Waring M.A. The variable metabolic response to dietary isoflavones in humans. Proc. Soc. Exp. Biol. Med. 208:1995;40-43.
13. Wiseman H. The bioavailability of non-nutrient plant factors dietary flavonoids and phyto-oestrogen . Proc. Nutr. Soc. 58:1999;139-146.
14. Steinberg D. A critical look at the evidence for the oxidation of LDL in atherogenesis. Atherosclerosis. 131:1997;S5-S7.
15. Berliner J.A., Heineicke J.W. The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med. 20:1996;707-727.
16. Wakatsuki A., Nobuo I., Sagara Y. Effects of estrogen on susceptibility to oxidation of low-density and high density lipoprotein in postmenopausal women. Maturitas. 28:1998;229-234.
17. Burr M.T., Sweetman P.T., Hurley R.J., Powell G.H. Effects of age and intake on plasma ascorbic acid levels. Lancet. 1:1974;163-164.
18. Day B.R., Williams D.R., Marsh C.A. A rapid manual method for routine assay of ascorbic acid in serum and plasma. Clin. Biochem. 12:1979;22-26.
19. Hwang J., Peterson H., Hodis H.N., Choi B., Sevanian A. Ascorbate enhances estradiol antioxidant activity (Abstract). Circulation. 100:2000;I330-I331.
20. Hwang J., Peterson H., Hodis H.N., Choi B., Sevanian A. Ascorbic acid enhances 17 β-estradiol mediated inhibition of oxidized low density lipoprotein formation. Atherosclerosis. 150:2000;275-284.
21. Hodis H.N., Kramsch D.M., Avogaro P., Bittolo-Bon G., Cazzolato G., Hwang J., Peterson H., Sevanian A. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). J. Lipid Res. 35:1994;669-677.
22. Auerbach B.J., Kiely J.S., Cornicelli J.A. A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. Anal. Biochem. 201:1992;375-380.
23. Bui M.H. Simple determination of retinol, α-tocopherol and carotenoids (lutein, all trans-lycopene, α and β carotenes) in human plasma by isocratic liquid chromatography. J. Chromatogr. B. Biomed. Applic. 654:1994;129-133.
24. Tubaro F., Ghiselli A., Rapuzzi P., Maiorino M., Ursini F. Analysis of plasma antioxidant capacity by competitive kinetics. Free Radic. Biol. Med. 24:1998;1228-1234.
25. Retsky K.L., Chen K., Zeind J., Frei B. Inhibition of copper-induced LDL oxidation by vitamin C is associated with decreased copper-binding to LDL and 2-oxo-histidine formation. Free Radic. Biol. Med. 26:1999;90-98.
26. Barnes S., Sfakiano J., Coward L., Kirk M. Soy isoflavonoids and cancer prevention. Underlying biochemical and pharmacological issues. Adv. Exp. Med. Biol. 401:1996;87-100.
27. Ursini F., Tubaro F., Rong J., Sevanian A. Optimization of nutrition polyphenols and vascular protection . Nutr. Rev. 57:1999;241-249.
28. Bors W., Heller W., Michel C., Saran M. Flavonoids as antioxidants determination of radical scavenging efficiencies . Methods Enzymol. 186:1990;343-355.
29. Smith L.L. Another cholesterol hypothesis cholesterol as an antioxidant . Free Radic. Biol. Med. 11:1991;47-92.
30. Sevanian, A.;McLeod, L. L. M. Formation and biological reactivity of lipid peroxidation products. In: Wallace, K. B., ed. Free radical toxicology, target organ toxicology series. Washington, DC: Taylor & Francis; 1997:47-70.
31. Neugarten J., Ghossein C., Silbiger S. Estradiol inhibits mesangial cell-mediated oxidation of low-density lipoprotein. J. Lab. Clin. Med. 126:1995;385-391.
32. Tang M., Ablanalp W., Subbiah M.T. Association of estrogens with human plasma lipoproteins studies using estradiol-17 β and its hydrophobic derivative . J. Lab. Clin. Med. 129:1997;447-452.
33. Maziere C., Auclair M., Ronveaux M.F., Salmon S., Santus R., Maziere J.C. Estrogens inhibit copper and cell-mediated modification of low density lipoprotein. Atherosclerosis. 89:1991;175-182.
34. Tang M., Abplanalp W., Ayres S., Subbiah M.T. Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation. Metabolism. 45:1996;411-414.
35. Shwaery G.T., Vita J.A., Keaney J.F. Antioxidant protection of LDL by physiological concentrations of 17 β-estradiol Requirement for estradiol modification . Circulation. 95:1997;1378-1385.
36. Huber L.A., Scheffler E., Poll T., Ziegler R., Dresel H.A. 17 beta-estradiol inhibits LDL oxidation and cholesterol ester formation in cultured macrophages. Free Radic. Res. Commun. 8:1990;167-173.
37. Mowri, H.; Nojima, S.; Inoue, K. Effect of lipid composition of liposomes on their sensitivity to peroxidation. J. Biochem. (Tokyo) 95: 551-558; 1984.
38. Sevanian A., Nordenbrand K., Kim E., Ernster L., Hochstein P. Microsomal lipid peroxidation the role of NADPH-cytochrome P-450 reductase and cytochrome P-450 . Free Radic. Biol. Med. 8:1990;145-152.
39. Berenbaum M.C. What is synergy? Pharmacol. Rev. 41:1989;93-141.