Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma

Oncology Reports

Volumn 7, Issue 4, 2000, Pages 831-836

  Sakatani, Takashi ^a   Okamoto, Eiji ^a   Tsujitani, Shunichi ^a   Ikeguchi, Masahide ^a   Kaibara, Nobuaki ^a   Ito, Hisao ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Gastric carcinoma; Microvessel count; p53; Thymidine phosphorylase; Vascular endothelial growth factor

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; PROTEIN P53; THYMIDINE PHOSPHORYLASE; VASCULOTROPIN; VASCULOTROPIN A;

ADENOMA; ARTICLE; CANCER STAGING; FEMALE; FOLLOW UP; HUMAN; MALE; MORTALITY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROGNOSIS; STOMACH TUMOR; SURVIVAL RATE; TIME; VASCULARIZATION;

ADENOMA; ENDOTHELIAL GROWTH FACTORS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHOKINES; MALE; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE; THYMIDINE PHOSPHORYLASE; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034220878     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.7.4.831     Document Type: Article

References (46)

1. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6, 1990.
2. Fidler I and Ellis LM: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79: 185-188, 1994.
3. Folkman J: How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes Memorial Award lecture. Cancer Res 46: 467-473, 1986.
4. Gasparini G, Weidner N, Bevilacqua P, Maluta S, Dalla Palma P, Caffo O, Barbareschi M, Boracchi P, Marubini E and Pozza F: Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J Clin Oncol 12: 454-466, 1994.
5. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S and Gasparini G: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84: 1875-1887, 1992.
6. Chung YS, Maeda K and Sowa M: Prognostic value of angiogenesis in gastro-intestinal tumours. Eur J Cancer 32: 2501-2505, 1996.
7. Weidner N: Tumoural vascularity as a prognostic factor in cancer patients. J Pathol 184: 119-122, 1998.
8. Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy JA, Sotrel A, Manseau EJ, van de Water L and Senger DR: Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J Exp Med 174: 1275-1278, 1991.
9. Plate KH, Breier G, Weich HA and Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
10. Schreiber AB, Winkler ME and Derynck R: Transforming growth factor-α: a more potent angiogenic mediator than epidermal growth factor. Science 232: 1250-1253, 1986.
11. Kandel J, Bossy-Wetzel E, Radvanyi F, Klagsbrun M, Folkman J and Hanahan D: Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell 66: 1095-1104, 1991.
12. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG and Strieter RM: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258: 1798-1801, 1992.
13. Miyadera K, Sumizawa T, Haraguchi M, Yoshida H, Konstanty W, Yamada Y and Akiyama S: Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res 55: 1687-1690, 1995.
14. Folkman J and Klagsburn M: Angiogenic factors. Science 235: 442-447, 1987.
15. Tada K, Fukunaga T, Wakabayashi Y, Masumi S, Sato Y, Izumi H, Kohno K and Kuwano M: Inhibition of tubular morphogenesis in human microvascular endothelial cells by co-culture with chondrocytes and involvement of transforming growth factor ß: a model for avascularity in human cartilage. Biochim Biophys Acta 1201: 135-142, 1994.
16. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH and Folkman J: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328, 1994.
17. Maheshwari RK, Srikantan V, Bhartiya D, Kleinman HK and Grant DS: Differential effects of interferon γ and α on in vitro model of angiogenesis. J Cell Physiol 146: 164-169, 1991.
18. Dameron KM, Volpert OV, Tainsky MA and Bouck N: The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin. Cold Spring Harb Symp Quant Biol 59: 483-489, 1994.
19. Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W and Heldin CH: Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338: 557-562, 1989.
20. Haraguchi M, Miyadera K, Uemura K, Sumizawa T, Furukawa T, Yamada K, Akiyama S and Yamada Y: Angiogenic activity of enzymes. Nature 368: 198, 1994.
21. Sumizawa T, Furukawa T, Haraguchi M, Yoshimura A, Takeyasu A, Ishizawa M, Yamada Y and Akiyama S: Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor. J Biochem 114: 9-14, 1993.
22. Maeda K, Chung YS, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, Sawada T and Sowa M: Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77: 858-863, 1996.
23. Maeda K, Chung YS, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, Sawada T, Onoda N, Kato Y and Sowa M: Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br J Cancer 73: 884-888, 1996.
24. Takahashi Y, Bucana CD, Akagi Y, Liu W, Cleary KR, Mai M and Ellis LM: Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin Cancer Res 4: 429-434, 1998.
25. Takebayashi Y, Miyadera K, Akiyama S, Hokita S, Yamada K, Akiba S, Yamada Y, Sumizawa T and Aikou T: Expression of thymidine phosphorylase in human gastric carcinoma. Jpn J Cancer Res 87: 288-295, 1996.
26. Tanigawa N, Amaya H, Matsumura M and Shimomatsuya T: Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma. J Clin Oncol 15: 826-832, 1997.
27. Takebayashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, Murata F and Aikou T: Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88: 1110-1117, 1996.
28. Fukuiwa T, Takebayashi Y, Akiba S, Matsuzaki T, Hanamure Y, Miyadera K, Yamada Y and Akiyama S: Expression of thymidine phosphorylase and vascular endothelial cell growth factor in human head and neck squamous cell carcinoma and their different characteristics. Cancer 85: 960-969, 1999.
29. Toi M, Hoshina S, Taniguchi T, Yamamoto Y, Ishitsuka H and Tominaga T: Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int J Cancer 64: 79-82, 1995.
30. Japanese Research Society for Gastric Cancer: Japanese classification of gastric cancer. 1st English edition. Kanehara and Co., Ltd., Tokyo, 1995.
31. Lauren P: The two histological main types of gastric carcinomas: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Immunol Scand 64: 31-49, 1968.
32. Hsu SM, Raine L and Fanger. H: Use of avidin-biolin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29: 577-580, 1981.
33. Miyadera K, Sumizawa T, Haraguchi M, Yoshida H, Konstanty W, Yamada Y and Akiyama S: Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res 55: 1687-1690, 1995.
34. Stevenson DP, Collins WP, Farzaneh F, Hata K and Miyazaki K: Thymidine phosphorylase activity and prodrug effects in a three-dimensional model of angiogenesis: implications for the treatment of ovarian cancer. Am J Pathol 153: 1573-1578, 1998.
35. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR and Ellis LM: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55: 3964-3968, 1995.
36. Obermair A, Kucera E, Mayerhofer K, Speiser P, Seifert M, Czerwenka K, Kaider A, Kaider A, Leodolter S, Kainz C and Zeillinger R: Vascular endothelial growth factor (VEGF) in human breast cancer: correlation with disease-free survival. Int J Cancer 74: 455-458, 1997.
37. Acenero MJ, Gallego MG, Ballesteros PA and Gonzalez JF: Vascular density as a prognostic indicator for invasive ductal breast carcinoma. Virchows Arch 432: 113-117, 1998.
38. Fontanini G, Vignati S, Boldrini L, Chine S, Silvestri V, Lucchi M, Mussi A, Angeletti CA and Bevilacqua G: Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res 3: 861-865, 1997.
39. Takahashi Y, Bucana CD, Cleary KR and Ellis LM: p53, vessel count, and vascular endothelial growth factor expression in human colon cancer. Int J Cancer 79: 34-38, 1998.
40. Kang SM, Maeda K, Onoda N, Chung YS, Nakata B, Nishiguchi Y and Sowa M: Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. Int J Cancer 74: 502-507, 1997.
41. Ambs S, Bennett WP, Merriam WG, Ogunfusika MO, Oser SM, Khan MA, Jones RT and Harris CC: Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Br J Cancer 78: 233-239, 1998.
42. Shomori K, Sakatani T, Goto A, Matsuura T and Ito H: Thymidine phosphorylation(dThdPase) expression in human colorectal adenoma and carcinoma: Role of p53 expression. Pathol Int 49: 491-499, 1999.
43. Takebayashi Y, Yamada K, Ohmoto Y, Sameshima T, Miyadera K, Yamada Y, Akiyama S and Aikou T: The correlation of thymidine phosphorylase activity with the expression of interleukin 1α, interferon a and interferon γ in human colorectal carcinoma. Cancer Lett 95: 57-62, 1995.
44. Makower D, Wadler S, Haynes H and Schwartz EL: Interferon induces thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in vivo. Clin Cancer Res 3: 923-929, 1997.
45. Kitazono M, Takebayashi Y, Ishitsuka K, Takao S, Tani A, Furukawa T, Miyadera K, Yamada Y, Aikou T and Akiyama S: Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase. Biochem Biophys Res Commun 253: 797-803, 1998.
46. Maeda K, Kang SM, Ogawa M, Onoda N, Sawada T, Nakata B, Kato Y, Chung YS and Sowa M: Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma. Int J Cancer 74: 545-550, 1997.