Carboxypeptidase-mediated metabolism of calcitonin gene-related peptide in human gingival crevicular fluid - A rôle in periodontal inflammation?

Journal of Clinical Periodontology

Volumn 27, Issue 7, 2000, Pages 499-505

  Lundy, Fionnuala T ^a   Salmon, Amanda L ^b   Lamey, Philip John ^a   Shaw, Christopher ^b   Linden, Gerard J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Calcitonin gene related peptide; Carboxypeptidase; Gingival crevicular fluid; Neurokinin A; Periodontitis; Substance P

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CARBOXYPEPTIDASE; NEUROKININ A; SUBSTANCE P;

ADULT; ARTICLE; CASE CONTROL STUDY; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; GINGIVITIS; HUMAN; HYDROLYSIS; MALE; MASS SPECTROMETRY; METABOLISM; NEUROGENIC INFLAMMATION; PERIODONTITIS;

ADULT; CALCITONIN GENE-RELATED PEPTIDE; CARBOXYPEPTIDASES; CASE-CONTROL STUDIES; FEMALE; GINGIVAL CREVICULAR FLUID; HUMANS; HYDROLYSIS; MALE; NEUROGENIC INFLAMMATION; NEUROKININ A; PERIODONTITIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTANCE P;

EID: 0034218658     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051x.2000.027007499.x     Document Type: Article

References (28)

1. Alstergren, P., Appelgren, A., Appelgren, B., Kopp, S., Lundeberg, T. & Theodorsson, E. (1995) Co-variation of neuropeptide Y, calcitonin gene-related peptide, substance P and neurokinin A in joint fluid from patients with temporomandibular joint arthritis. Archives of Oral Biology 40, 127-135.
2. Basbaum, A. I. & Levine, J. D. (1991) The contribution of the nervous system to inflammation and inflammatory disease. Canadian Journal of Physiology and Pharmacology 69, 647-651.
3. Brain, S. D. & Williams, T. J. (1988) Substance P regulates the vasodilatory activity of CGRP. Nature 313, 54-56.
4. Eley, B. M. & Cox, S. W. (1992a) Cathepsin B/L-, elastase-, tryptase-, trypsin-, and dipeptidyl peptidase IV-like activities in gingival crevicular fluid: correlation with clinical parameters in untreated chronic periodontitis patients. Journal of Periodontal Research 27, 62-69.
5. Eley, B. M. & Cox, S. W. (1992b) Correlation of gingival crevicular fluid proteases with clinical and radiological measurements of periodontal attachment loss. Journal of Dentistry 20, 90-99.
6. Gibson, S. J., Polak, J. M., Bloom, S. R., Sabate, I. M., Mulderry, P. M., Ghatei, M. A., McGregor, G. P., Morrison, J. F. B., Kelly, J. S., Evans, R. M. & Rosenfeld, M. G. (1984) Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. Journal of Neuroscience 4, 3101-3111.
7. Goldstein, S. M., Kaempfer, C. E., Kealey, J. T. & Wintroub, B. U. (1989) Human mast cell carboxypeptidase. Purification and characterisation. Journal of Clinical Investigation 83, 1630-1636.
8. Györfi, A., Fazekas, A., Irmes, F., Jakab, G., Suto, T. & Rosivall, L. (1993) Role of substance P (SP) in the development of symptoms of neurogenic inflammation in the oral mucosa of the rat. Journal of Periodontal Research 28, 191-196.
9. Hoyle, C. H. V. (1996) Neuropeptides: essential data, pp 112-114. Chichester: John Wiley and Sons.
10. Jackman, H. L., Tan, F., Tamei, H., Beurling-Harbury, C., Li, X.-Y., Skidgel, R. A. & Erdos, E. G. (1990) A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal 'protective protein'. Journal of Biological Chemistry 265, 11265-11272.
11. Jones, D. A., Cummings, J., Langdon, S. P., Maclellan, A. & Smith, J. F. (1995) Characterisation of the deamidase enzyme responsible for the metabolism of the anticancer peptide - H-ARG-D-TRP-N(ME) PHE-D-TRP-LEU-MET-NH2 Biochemical Pharmacology 50, 585-590.
12. Katayama, M., Nadel, J. A., Bunnett, N. W., Di Maria, G. U., Haxhiu, M. & Borson, D. B. (1991) Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase. Peptides 12, 563-567.
13. Konttinen, Y. T., Imai, S. & Suda, A. (1996) Neuropeptides and the puzzle of bone remodelling. Acta Orthopaedica Scandinavica 67, 632-639.
14. Le Greves, P., Nyberg, F., Hokfelt, T & Terenius, L. (1989) Calcitonin gene-related peptide is metabolised by an endopeptidase hydrolysing substance P. Regulatory Peptides 25, 277-286.
15. Levine, J. D., Collier, D. H., Basbaum, A. I, Moskowitz, M. A. & Helms, C. A. (1985) Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. Journal of Rheumatology 12, 406-411.
16. Linden, G. J., McKinnell, J., Shaw, C. & Lundy, E T. (1997) Substance P and neurokinin A in gingival crevicular fluid in periodontal health and disease. Journal of Clinical Periodontology 24, 799-803.
17. Löe, H. & Silness, J. (1963) Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavica 21, 533-551.
18. Lundberg, J. M., Franco Cereceda, A., Hua, X., Hokfelt, T., Fischer, J. A. (1985) Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. European Journal of Pharmacology 108, 315-319.
19. Lundy, F. T., Shaw, C., McKinnell, J., Larney, P.-J. & Linden, G. J. (1999) Calcitonin gene-related peptide in gingival crevicular fluid in periodontal health and disease. Journal of Clinical Periodontology 26, 212-216.
20. Machtei, E., Christersson, L., Grossi, S., Dunford, R., Zambon, J. & Genco, R. (1992) Clinical criteria for the definition of 'Established Periodontitis' Journal of Periodontology 63, 206-214.
21. Maggi, C. (1995) Tachykinins and calcitonin gene-related peptide (CGRP) as cotransmitters released from peripheral endings of sensory nerves. Progress in Neurobiology 45, 1-98.
22. Makinen, P.-L., Makinen, K. K. & Syed, S. A. (1995) Role of the chymotrypsin-like membrane-associated proteinase from Treponema denticola ATCC 35405 in inactivation of bioactive peptides. Infection and Immunity 63, 3567-3575.
23. Mentlein, R. & Roos, T. (1996) Proteases involved in the metabolism of angiotensin II, bradykinin, calcitonin gene-related peptide (CGRP), and neuropeptide Y by vascular smooth muscle cells. Peptides 17, 709-720.
24. Nyberg, F., Le Greves, P., Sundqvist, C. & Terenius, L. (1984) Characterisation of substance P(1-7) and (1-8) generating enzyme in human cerebrospinal fluid. Biochemical and Biophysical Research Communications 125, 244-250.
25. Quing Cao, Y., Mantyh, P. W., Carlson, E. J., Gillespie, A.-M., Epstein, C. J. & Basbaum, A. I. (1998) Primary afferent tachykinins are required to experience moderate to intense pain. Nature 392, 390-394.
26. Schechter, N. M., Choi, J. K., Slavin, D. A., Deresienski, D. T., Sayama, S., Dong, G., Lavker, R. M., Proud, D. & Lazarus, G. S. (1986) Human skin chymotryptic protease. Identification of a chymotrypsin-like proteinase in human mast cells. Journal of Immunology 137, 962-970.
27. Schwartz, L. B., Lewis, R. A. & Austen, K. F. (1981) Tryptase from human pulmonary mast cells. Purification and characterisation. Journal of Biological Chemistry 256, 11939-11943.
28. Turner, A. J. (1986) Processing and metabolism of neuropeptides. Essays in Biochemistry 22, 69-119.