Allele frequency of human endothelial nitric oxide synthase gene polymorphism in abdominal aortic aneurysm

Internal Medicine

Volumn 39, Issue 7, 2000, Pages 537-539

  Kotani, Kazuhiko ^a,b   Shimomura, Tokio ^a   Murakami, Fumiyo ^a   Ikawa, Shiro ^a   Kanaoka, Yasushi ^a   Ohgi, Shigetsugu ^a   Adachi, Kaori ^c   Nanba, Eiji ^c  

^a TOTTORI UNIVERSITY   (Japan)

^b Department of Internal Medicine   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

Atherosclerotic factor; Intron 4 of the ecNOS gene; Nitric oxide; Surgical treatment

Indexed keywords

NITRIC OXIDE SYNTHASE;

ABDOMINAL AORTA ANEURYSM; AGED; ALLELE; ARTICLE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; INTRON; MALE; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

AGED; AGED, 80 AND OVER; ALLELES; AORTIC ANEURYSM, ABDOMINAL; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; INTRONS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC;

EID: 0034218612     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.39.537     Document Type: Article

References (14)

1. Sonesson B, Hansen F, Lanne T. Abdominal aortic aneurysm: a general defect in the vasculature with focal manifestations in the abdominal aorta? J Vasc Surg 26: 247-254, 1997.
2. Alcorn HG, Wolfson SK Jr, Sutton-Tyrrell K, Kuller LH, O'Leary D. Risk factors for abdominal aortic aneurysms in older adults enrolled in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 16: 963-970, 1996.
3. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980.
4. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142, 1991.
5. Bonnardeaux A, Nadaud S, Charru A, Jeunemaitre X, Corvol P, Soubrier F. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation 91: 96-102, 1995.
6. Marsden PA, Heng HHQ, Scherer SW, et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268: 17478-17488, 1993.
7. Wang XL, Sim AS, Badenhop RF, McCredie RM, Wilcken DEL. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nature Med 2: 41-45, 1996.
8. Yokoyama K, Tsukada T, Matsuoka H, Hara S, Yamada A, Kawaguchi Y. High accumulation of ecNOS: a gene polymorphism in patients with end-stage renal disease. Nephron 79: 360-361, 1998 (letter).
9. Uwabo J, Soma M, Nakayama T, Kanmatsuse K. Association of a variable number of tandem repeats in the ecNOS gene with essential hypertension in Japanese. Am J Hypertens 11: 125-128, 1998.
10. Reitsma JB, Pleumeekers HJ, Hoes AW, et al. Increasing incidence of aneurysms of the abdominal aorta in The Netherlands. Eur J Vasc Endovasc Surg 12: 446-451, 1996.
11. Miyahara K, Kawamoto T, Sase K, et al. Cloning and structural characterization of the human endotherial nitric-oxide-synthase gene. Eur J Biochem 223: 719-726, 1994.
12. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 323: 27-36, 1990.
13. Tsukada T, Yokoyama K, Arai T. et al. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 245: 190-193, 1998.
14. Wang XL, Mahaney MC, Sim AS, et al. Genetic contribution of the ecNOS gene to plasma NO levels. Arterioscler Thromb Vasc Biol 17: 3147-3153, 1997.