Human health consequences of environmentally-modulated gene expression: Potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease

Bioelectromagnetics

Volumn 21, Issue 5, 2000, Pages 402-406

  Trosko, James E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cell cell communication; EMF; Epigenetic effects

Indexed keywords

CELL DEATH; CELL PROLIFERATION; CELL SIGNALING; ELECTROMAGNETIC FIELDS;

CELL-CELL COMMUNICATIONS; ENVIRONMENTAL AGENTS; EPIGENETIC EFFECT; EPIGENETICS; EXTREMELY LOW FREQUENCY ELECTROMAGNETIC FIELDS; FIELD-INDUCED; GENES EXPRESSION; HEALTH CONSEQUENCES; HUMAN HEALTH; MECHANISTICS;

GENE EXPRESSION;

BIOLOGICAL MODEL; DNA DAMAGE; ELECTROMAGNETIC FIELD; ENVIRONMENTAL HEALTH; GENE EXPRESSION; GENERAL ASPECTS OF DISEASE; GENETICS; HUMAN; MUTATION; NEOPLASM; REVIEW;

DISEASE; DNA DAMAGE; ELECTROMAGNETIC FIELDS; ENVIRONMENTAL HEALTH; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS;

EID: 0034218591     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-186X(200007)21:5<402::AID-BEM9>3.0.CO;2-N     Document Type: Review

References (19)

1. Boorman GA, Anderson LE, Morris JE, Sasser LB, Mann PC, Grumbein SL, Hailey JR, McNalley A, Sills RC, Haseman JK. 1999. Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats. Carcinogenesis 20:899-904.
2. Brody H. 1973. A systems view of man: implications for medicine, science and ethics. Perspect Biol Med 17:71-92.
3. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. 1984. Controlled death (apoptosis) of normal and putative pre-neoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5:453-458.
4. Chang CC, Trosko JE, Yotti LP, Schultz RA. 1979. The use of Chinese hamster V79 cells for the detection of mutagens and tumor promoters or antipromoters. In: Banbury Report 2: Mammalian cell mutagenesis: the maturation of test systems. Cold Spring Harbor Laboratory, p 89-98.
5. Imaida K, Taki M, Yamaguchi T, Ito T, Watanabe S, Wake K, Aimoto A, Kaminura Y, Ito N, Shirai T. 1998. Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay. Carcinogenesis 19:311-314.
6. McCann J, Dietric F, Rafferty C. 1998. The genotoxic potential of electric and magnetic fields: an update. Mutat Res 411: 45-86.
7. McCann J, Kheifets L, Rafferty C. 1998. Cancer risk assessment of extremely low frequency electric and magnetic fields: a critical review of methodology. Environ Health Persp 106:701-717.
8. McCormick DL, Ryan BM, Findlay JC, Gauger JR, Johnson TR, Morrissey RL, Boorman GA. 1998. Exposure to 60 Hz magnetic fields and risks of lymphoma in PIM transgenic and TSG-p53 (p53 knockou:) mice. Carcinogenesis 19: 1649-1653.
9. Miyakoshi J, Koji Y, Wakasa T, Takebe H. 1999. Long term exposure to a magnetic field (5 m T at 60 Hz) increases X-ray-induced mutations. J Radiat Biol 40:13-21.
10. NIEHS. 1999. Report on Health effects from exposures to power-line frequency electric and magnetic fields. NIH Publication No. 99-4493.
11. NRC. 1997. Possible health effects of exposure to residential electric and magnetic fields. Washington, DC: National Research Council.
12. Potter VR. 1974. Probabilistic aspects of the human cybernetic machine. Perspect Biol Med 17:164-183.
13. Sasser LB, Anderson LE, Morris JE, Miller DL, Walborg EF, Kavet R, Johnson DA, Digiovanni J. 1998. Lack of a co-promoting effect of a 60 Hz magnetic field on skin tumorigenesis in SENCAR mice. Carcinogenesis 19: 1617-1621.
14. Trosko JE. 1997. Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm. Mutat Res 373:245-249.
15. Trosko JE, Chang CC, Madhukar BV, Dupont E. 1996. Inter-cellular communication: a paradigm for the interpretation of the initiation/promotion/progression model of carcinogenesis. In: Chemical induction of cancer: modulation and combination effects. Arcos JC, Argus MFM, Woo YT, editors. Boston: Birkhauser Publ. p 205-225.
16. Trosko JE, Ruch RJ. 1998. Cell-cell communication in carcinogenesis. Front Bioscience 3:208-236; http://www.bioscience.org
17. Walleczek J, Shiu EC, Hahn GM. 1999. Increase in radiation-induced HPRT Gene mutation frequency after nonterminal exposure to nonionizing 60 Hz electromagnetic fields. Radiat Res 151:489-497.
18. Weinstein IB, Gattoni S, Kirschmeirer P, Lambert M, Hsiao W, Backer J, Jeffery A. 1984. Multistage carcinogenesis involves multiple genes and multiple mechanisms. J Cellul Physiol 3:127-137.
19. Yotti LP, Chang CC, Trosko JE. 1979. Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. Science 206:1089-1091.