Chromosomal breakage in the B. fragilis group induced by metronidazole treatment

Anaerobe

Volumn 6, Issue 3, 2000, Pages 149-153

  Diniz, Cláudio Galuppo ^a   Santos, Simone G ^a   Pestana, Ana Cristina N R ^a   Farias, Luiz M ^a   Carvalho, Maria Auxiliadora R ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

B. fragilis group; Chromosomal breakage; Metronidazole

Indexed keywords

BACTERIAL DNA; METRONIDAZOLE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTEROIDES FRAGILIS; CHROMOSOME BREAKAGE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034212594     PISSN: 10759964     EISSN: None     Source Type: Journal    
DOI: 10.1006/anae.2000.0332     Document Type: Article

References (18)

1. Freeman C. D., Klutman N. E., Lamp K. C. Metronidazole: a therapeutic review and update. Drugs. 54:1997;679-708.
2. Barnhost D. A. Jr, Foster J. A., Chern K. C., Meisler D. M. The efficacy of topical metronidazole in the treatment of ocular rosacea. Ophthalmology. 103:1996;1880-1883.
3. Land K. M., Johnson P. J. Molecular mechanisms underlying metronidazole resistance in trichomonads. Exp Parasitol. 87:1997;305-308.
4. Jang S. S., Breher J. E., Dabaco L. A., Hirsh D. C. Organisms isolated from dogs and cats with anaerobic infections and susceptibility to selected antimicrobial agents. J Am Vet Med Association. 210:1997;1610-1614.
5. Rasmussen B. A., Bush K., Tally F. P. Antimicrobial resistance in anaerobes. Clin Infect Dis. 24:1997;S110-S120.
6. Jaup B. H., Brandberg A., Stenquist B., Norrby A. Antibiotic resistance among strains of Helicobacter pylori in Gothenburg. Bacteria resistant to metronidazole. Lakartidningen. 95:1998;279-281.
7. Edwards D. I. Nitroimidazole drugs - action and resistance mechanisms. I. Mechanism of action. J Antimic Chemother. 31:1993;9-20.
8. Castelli M., Malagoli M., Ruberto A. I., Baggio A., Casolari C., Carmelli C., Bossa M. R., Rossi T., Paolucci F., Roffia S. In-vitro studies of two 5-nitroimidazoles derivatives. J Antimic Chemother. 40:1997;19-25.
9. Sigeti J. S., Guiney D. G. Jr, Davis C. E. Mechanism of action of metronidazole on Bacteroides fragilis. J Infect Dis. 148:1983;1083-1089.
10. Müller M. Mode of action of metronidazole on anaerobic bacteria and protozoa. Surgery. 93:1983;165-171.
11. Duerden B. I., Drasar B. S. Anaerobes in Human Disease. 1991;Edward Arnold, a division of Holder & Stoughton, London, Melbourne.
12. Tabaqchali S., Wilks M. Epidemiological aspects of infections by Bacteroides fragilis and Clostridium difficile. Eur J Clin Microbiol Infect Dis. 11:1992;1049-1057.
13. Summanen P., Baron E. J., Citron D. M., Strong C. A., Wexler H. M., Finegold S. M. Wadsworth Anaerobic Bacteriology Manual. 1993;Star Publishing Company.
14. Dachs G. U., Abratt V. R., Woods D. R. Mode of action of metronidazole and a Bacteroides fragilis metA resistance gene in Escherichia coli. J Antimic Chemother. 35:1995;483-496.
15. Church D. L., Bryant R. D., Rabin H. R., Laishley E. J. Physiological effects of metronidazole on Clostridium pasteurianum. J Antimic Chemother. 28:1991;221-228.
16. Knight R. C., Skolimowski I. M., Edwards D. I. The interaction of reduced metronidazole with DNA. Biochem Pharmacol. 27:1978;2089-2093.
17. Jackson D., Salem A., Coombs G. H. The in-vitro activity of metronidazole against strains of Escherichia coli with impaired DNA repair systems. J Antimic Chemother. 13:1984;227-236.
18. Edwards D. I. Reduction of nitroimidazoles in vitro and DNA damage. Biochem Pharmacol. 35:1986;53-58.