The structural basis of CEACAM-receptor targeting by neisserial Opa proteins

Trends in Microbiology

Volumn 8, Issue 6, 2000, Pages 258-260

  Billker, Oliver ^a   Popp, Andreas ^a   Gray Owen, Scott D ^b   Meyer, Thomas F ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CELL ADHESION MOLECULE; FIBRONECTIN; INTEGRIN; OUTER MEMBRANE PROTEIN; PROTEOHEPARAN SULFATE; VITRONECTIN;

ANTIGENIC VARIATION; BACTERIAL COLONIZATION; CELL ADHESION; ENDOTHELIUM CELL; EPITHELIUM CELL; INTERNALIZATION; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RECEPTOR BINDING; SHORT SURVEY; TRANSCYTOSIS;

EID: 0034212351     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-842X(00)01771-6     Document Type: Short Survey

References (11)

1. C. Dehio The role of neisserial Opa proteins in interactions with host cells Trends Microbiol. 6 1998 489 495
2. X. Nassif Interactions of pathogenic Neisseria with host cells. Is it possible to assemble the puzzle? Mol. Microbiol. 32 1999 1124 1132
3. N. Beauchemin Redefined nomenclature for members of the carcinoembryonic antigen family Exp. Cell Res. 252 1999 243 249
4. B. Obrink CEA adhesion molecules: multifunctional proteins with signal-regulatory properties Curr. Opin. Cell Biol. 9 1997 616 626
5. T. Chen Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins J. Exp. Med. 185 1997 1557 1564
6. M. Virji Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae : identification of Opa adhesiotopes on the N-domain of CD66 molecules Mol. Microbiol. 34 1999 538 551
7. M. Virji The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae Mol. Microbiol. 22 1996 929 939
8. M.P. Bos Homologue scanning mutagenesis reveals CD66 receptor residues required for neisserial Opa protein binding J. Exp. Med. 190 1999 331 340
9. A. Popp Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding Cell. Microbiol. 1 1999 169 181
10. C.C. Grant Proteoglycan receptor binding by Neisseria gonorrhoeae MS11 is determined by the HV-1 region of OpaA Mol. Microbiol. 32 1999 233 242
11. S.R. Hedges Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections Infect. Immun. 67 1999 3937 3946