Inhibition of the Activation and Collagen Production of Cultured Rat Hepatic Stellate Cells by Antisense Oligonucleotides Against Transforming Growth Factor-β 1 Is Enhanced by Cationic Liposome Delivery

Journal of West China University of Medical Sciences

Volumn 31, Issue 2, 2000, Pages 133-135

  Liu, Xiaojing ^a   Zhang, Zheng ^a   Yang, Li ^a   Chen, Dezhen ^a   Wang, Yiping ^a  

^a FIRST AFFILIATED HOSPITAL   (China)

Author keywords

Antisense oligonucleotides; Cationic liposome; Hepatic stellate cell; Transforming growth factor 1

Indexed keywords

1,2 DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; 1,2-DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; ACTIN; ANTISENSE OLIGONUCLEOTIDE; CATION; COLLAGEN; LIPOSOME; PHOSPHATIDYLETHANOLAMINE; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; LIVER CELL; LIVER CIRRHOSIS; MALE; METABOLISM; RAT; SECRETION; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; CATIONS; CELLS, CULTURED; COLLAGEN; HEPATOCYTES; LIPOSOMES; LIVER CIRRHOSIS; MALE; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHATIDYLETHANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0034212120     PISSN: 02577712     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Bissell DM. Hepatic fibrosis as wound repair: A progress report. J Gastroenterol, 1998; 33(2): 295
2. Gao X, Huang L. Cationic liposome-mediated gene transfer. Gene Therapy, 1995; 2(10): 710
3. 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells. Gene, 1994; 149(1): 25
4. 1 protein by antisense oligonucleotide-induced increase of adrenal cell differentiated functions. J Biol Chem, 1996; 271(18): 11027
5. Soni PN, Brown D, Saffie R, et al. Biodistribution, stability, and antiviral efficacy of liposome-entrapped phosphorathioate antisense oligodeoxynucleotides in ducks for the treatment of chronic duck hepatitis B virus infection. Hepatology, 1998; 28 (5): 1402
6. Wielbo D, Shi N, Sernia C. Antisense inhibition of angioten-sinogen in hepatoma cell culture is enhanced by cationic liposome delivery. Biochem Biophys Res Commun, 1997; 232(3): 794