The micromechanical environment of intervertebral disc cells: Effect of matrix anisotropy and cell geometry predicted by a linear model

Journal of Biomechanical Engineering

Volumn 122, Issue 3, 2000, Pages 245-251

  Baer, Anthony E ^a   Setton, Lori A ^a  

^a Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOTROPY; CELLS; MATHEMATICAL MODELS; MORPHOLOGY; STRAIN; STRESS ANALYSIS;

INTERVERTEBRAL DISC CELLS;

BIOMECHANICS;

ANISOTROPY; ARTICLE; CELL STRUCTURE; GEOMETRY; INTERVERTEBRAL DISK; MECHANICAL STRESS; STATISTICAL MODEL; STRESS STRAIN RELATIONSHIP;

ANIMALS; ANISOTROPY; BIOMECHANICS; ELASTICITY; EXTRACELLULAR MATRIX; INTERVERTEBRAL DISK; LINEAR MODELS; MODELS, BIOLOGICAL; PHENOTYPE; PREDICTIVE VALUE OF TESTS; SWINE; TENSILE STRENGTH; WEIGHT-BEARING;

EID: 0034210532     PISSN: 01480731     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.429655     Document Type: Article

References (54)

1. Taylor, J. R., and Twomey, L. T., 1988, "The Development of the Human Intervertebral Disc," The Biology of the Intervertebral Disc, P. Ghosh, ed., CRC Press, Boca Raton, FL, 1, pp. 39-82.
2. Oegema, T. R., Jr., 1993, "Biochemistry of the Intervertebral Disc," Clin. Sports Med., 12, pp. 419-439.
3. Errington, R. J., Puustjarvi, K., White, I. R. F., Roberts, S., and Urban, J. P. G., 1998, "Characterization of Cytoplasm-Filled Processes in Cells of the Intervertebral Disc," J. Anat., 192, pp. 369-378.
4. Higuchi, M., and Abe, K., 1987, "Postmortem Changes in Ultrastructures of the Mouse Intervertebral Disc," Spine, 12, pp. 48-52.
5. Postacchini, F., Bellocci, M., and Massobrio, M., 1984, "Morphologic Changes in Anulus Fibrosus During Aging: An Ultrastructural Study in Rats," Spine, 9, pp. 596-603.
6. Cassidy, J. J., Hiltner, A., and Baer, E., 1989, "Hierarchical Structure of the Intervertebral Disc," Connect. Tissue Res., 23, pp. 75-88.
7. Marchand, F., and Ahmed, A. M., 1990, "Investigation of the Laminate Structure of Lumbar Disc Anulus Fibrosus," Spine. 15, pp. 402-410.
8. Trout, J. J., Buckwalter, J. A., Moore, K. C., and Landas, S. K., 1982, "Ultrastructure of the Human Intervertebral Disc: I. Changes in Notochordal Cells With Age," Tissue Cell, 14, pp. 359-369.
9. Weidenbaum, M., Iatridis, J. C. Setton, L. A., Foster, R. J., and Mow, V. C., 1996, "Mechanical Behavior of the Intervertebral Disc and the Effects of Degeneration," Low Back Pain: A Scientific and Clinical Overview, J. N. Weinstein et al., eds., American Academy of Orthopaedic Surgeons, Rosemont. IL, pp. 557-582.
10. Urban, J. P. G., 1993, "The Effect of Physical Factors on Disc Cell Metabolism," Musculoskeletal Soft-Tissue Aging: Impact on Mobility, J. A. Buckwalter et al., eds., American Academy of Orthopaedic Surgeons, Rosemont, IL, pp. 391-412.
11. Guilak, F., Sah, R. L., and Setton, L. A., 1997, "Physical Regulation of Cartilage Metabolism," Basic Orthopaedic Biomechanic, V. C. Mow et al., eds., Lippincott-Raven Publishers, Philadelphia, pp. 179-207.
12. Hutton, W. C., Toribatake, Y., Elmer, W. A., Ganey, T. M., Tomita, K., and Whitesides, T. E., 1998, "The Effect of Compressive Force Applied to the Intervertebral Disc in Vivo: A Study of Proteoglycans and Collagen," Spine, 23, pp. 2524-2537.
13. Iatridis, J. C., Mente, P. L., Stokes, I. A. F., Aronsson, D. D., and Alini, M., 1999, "Compression-Induced Changes in Intervertebral Disc Properties in a Rat Tail Model," Spine, 24, pp. 996-1002.
14. Lotz J. C., Colliou, O. K., Chin, J. R., Duncan, N. A., and Liebenberg, E., 1998, "Compression-Induced Degeneration of the Intervertebral Disc: An in Vivo Mouse Model and Finite Element Study," Spine, 23, pp. 2493-2506.
15. Baer, A. E., Wang, J. Y., Kraus, V. B., and Setton, I., A., 2000. "Changes in Aggrecan and Collagen Gene Expression in Anulus Fibrosus Cells Subjected to Static Compression In Vitro." Trans. Orthopaedic Res. Soc., 25, p. 336.
16. Handa, T., Ishihara, H., Ohshima, H., Osada, R., Tsuji, H., and Obata, K., 1997, "Effects of Hydrostatic Pressure on Matrix Synthesis and Matrix Metalloproteinase Production in the Human Lumbar Intervertebral Disc," Spine, 22, pp. 1085-1091.
17. Hutton, W. C., Elmer, W. A., Boden, S. D., Hyon, S., Toribatake, Y., Tomita, K., and Hair, G. A., 1999. "The Effect of Hydrostatic Pressure on Intervertebral Disc Metabolism." Spine, 24, pp. 1507-1515.
18. Ishihara, H., McNally, D. S., Urban, J. P. G., and Hall, A. C., 1996. "Effects of Hydrostatic Pressure on Matrix Synthesis in Different Regions of the Intervertebral Disc," J. Appl. Physiol., 80, pp. 839-846.
19. Ohshima, H., Urban, J. P. G., and Bergel, D. H., 1995, "Effect of Static Load on Matrix Synthesis Rates in the Intervertebral Disc Measured In Vitro by a New Perfusion Technique," J. Orthop. Res., 13, pp. 22-29.
20. Mow, V. C., Wang, C. C., and Hung, C. T., 1999, "The Extracellular Matrix, Interstitial Fluid and Ions as a Mechanical Signal Transducer in Articular Cartilage," Osteoarthritis Cartilage. 7, pp. 41-58.
21. Jain, M. K., Berg, R. A., and Tandon, G. P., 19901, "Mechanical Stress and Cellular Metabolism in Living Soft Tissue Composites," Biomaterials, 11, pp. 465-472.
22. Bachrach, N. M., Valhmu, W. B., Stazzone, E., Ratcliffe, A., Lai, W. M., and Mow, V. C., 1995, "Changes in Proteoglycan Synthesis of Chondrocytes in Articular Cartilage Are Associated With the Time-Dependent Changes in Their Mechanical Environment," J. Biomech., 28, pp. 1561-1569.
23. Guilak, F., and Mow, V. C., 1992, "Determination of the Mechanical Response of the Chondrocyte In Situ Using Finite Element Modeling and Confocal Microscopy," Advances in Bioengineering, M. W. Bidez, ed., ASME BED-Vol. 22, pp. 21-23.
24. Mow, V. C., Sun, D. N., Guo, X. E., Hung, C. T., and Lai, W. M., 1999. "Chondrocyte-Extracellular Matrix Interactions During Osmotic Swelling," Proc. 1999 Bioengineering Conference, V. K. Goel, et al., eds., ASME BED-Vol. 42, pp. 133-134.
25. Wu, J. Z., Herzog, W., and Epstein, M., 1999, "Modelling of Location-and Time-Dependent Deformation of Chondrocytes During Cartilage Loading," J. Biomech., 32, pp. 563-572.
26. Guilak, F., Ting-Beall, H. P., Baer, A. E., Trickey, W. R., Erickson, G. R., and Setton, L. A., 1999, "Viscoelastic Properties of Intervertebral Disc Cells: Identification of Two Biomechanically Distinct Cell Populations," Spine, 24, pp. 2475-2483.
27. Elliott, D. M., and Setton, L. A,. 1999, "Direct Measurement of a Complete Set of Orthotropic Material Properties for the Human Anulus Fibrosus in Tension," Proc. 1999 Bioengineering Conference, V. K. Goel et al., eds., ASME BED-Vol. 42, pp. 75-76.
28. Fujita, Y., Duncan, N. A., and Lotz, J. C., 1996, "Anisotropic Shear Behavior of the Anulus Fibrosus: Effect of Harvest Site and Tissue Prestrain," Trans. Orthopaedic Res. Soc., 21, p. 271.
29. Fujita, Y., Duncan, N. A., and Lotz J. C., 1997, "Radial Tensile Properties of the Lumbar Anulus Fibrosus Are Site and Degeneration Dependent." J. Orthop. Res., 15, pp. 814-819.
30. Iatridis, J. C., Kumar, S., Foster, R. J., Weidenbaum, M., and Mow, V. C., 1999, "Shear Mechanical Properties of Human Lumbar Anulus Fibrosus," J. Orthop. Res., 17, pp. 732-737.
31. Chen, W. T., 1968, "Axisymmetric Stress Field Around Spheroidal Inclusions and Cavities in a Transversely Isotropic Material," ASME J. Appl. Mech., 35, pp. 770-773.
32. Green, A. E., and Zerna, W., 1968, Theoretical Elasticity, Clarendon, Oxford.
33. Lai, W. M., Rubin, D., and Krempl, E., 1993, Introduction to Continuum Mechanics, Pergamon Press, New York.
34. Eshelby, J. D., 1957, "The Determination of the Elastic Field of an Ellipsoidal Inclusion, and Related Problems," Proc. R. Soc. London, Ser. A, 241, pp. 376-396.
35. Goodier, J. N., 1933, "Concentration of Stress Around Spherical and Cylindrical Inclusions and Flaws," Trans. ASME, 55, Paper No. APM-55-7, pp. 39-44.
36. Stokes, I. A. F., 1987, "Surface Strain on Human Intervertebral Discs," J. Orthop. Res., 5, pp. 348-355.
37. Spilker, R. L., Donzelli, P. S., and Mow, V. C., 1992. "A Transversely Isotropic Biphasic Finite Element Model of the Meniscus," J. Biomech., 25, pp. 7 1027-1045.
38. Zhu, W., Chern, K. Y., and Mow, V. C., 1994, "Anisotropic Viscoelastic Shear Properties of Bovine Meniscus," Clin. Orthop. Related Res., 306, pp. 34-45.
39. Buschmann, M. D., Hunziker, E. B., Kim, Y.-J., and Grodzinsky, A. J., 1996, "Altered Aggrecan Synthesis Correlates With Cell and Nucleus Structure in Statically Compressed Cartilage." J. Cell. Sci., 109, pp. 499-508.
40. Guilak, F., Ratcliffe, A., and Mow, V. C. 1995, "Chondrocyte Deformation and Local Tissue Strain in Articular Cartilage: A Confocal Microscopy Study," J. Orthop. Res., 13, pp. 410-421.
41. Ishihara, H., Warensjo, K., Roberts, S., and Urban, J. P. G., 1997. "Proteoglycan Synthesis in the Intervertebral Disc Nucleus: The Role of Extracellular Osmolality." Am. J. Phys., 272, pp. C1499-C1506.
42. Errington, R. J., Fricker, M. D., Wood, J. L., Hall, A. C., and White, N. S., 1997. "Four-Dimensional Imaging of Living Chondrocytes in Cartilage Using Confocal Microscopy: A Pragmatic Approach," Am. J. Phys., 272. pp. C1040-C1051.
43. Lang, F., Busch, G. L., Ritter, M., Völkl, H., Waldegger, S., Gulbins, E., and Häussinger, D., 1998, "Functional Significance of Cell Volume Regulatory Mechanisms," Physiol. Rev., 78, pp. 247-306.
44. Mow, V. C., Kuel, S. C., Lai, W. M., and Armstrong, C. G., 1980, "Biphasic Creep and Stress Relaxation of Articular Cartilage in Compression: Theory and Experiments," ASME J. Biomech. Eng., 102, pp. 73-84.
45. Lai, W. M., Hou, J. S., and Mow, V. C., 1991, "A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage," ASME J. Biomech. Eng., 113, pp. 245-258.
46. Bayliss, M. T., Urban, J. P. G., Johnstone, B., and Holm, S. H., 1986, "In Vitro Method for Measuring Synthesis Rates in the Intervertebral Disc," J. Orthop. Res., 4, pp. 10-17.
47. Langille, B L., and Adamson, S. L., 1981, "Relationship Between Blood Flow Direction and Endothelial Cell Orientation at Arterial Branch Sites in Rabbits and Mice," Circ. Res., 48, pp. 481-488.
48. Nerem, R. M., Levesque, M. J., and Cornhill, J. F., 1981, "Vascular Endothelial Morphology as an Indicator of the Pattern of Blood Flow," ASME J. Biomech. Eng., 103, pp. 172-176.
49. Dewey, C. F., Jr., Bussolari, S. R., Gimbrone, M. A., Jr., and Davies, P. F., 1981, "The Dynamic Response of Vascular Endothelial Cells to Fluid Shear Stress," ASME J. Biomech. Eng. 103, pp. 177-185.
50. Smith, R. L., Donlon, B. S., Gupta, M. K., Mohtai, M., Das, P., Carter, D. R., Cooke, J., Gibbons, G., Hutchinson, N., and Schurman, D. J., 1995, "Effects of Fluid-Induced Shear on Articular Chondrocyte Morphology and Metabolism In Vitro," J. Orthop. Res., 13, pp. 824-83.
51. Buck, R. C., 1980, "Reorientation Response of Cells to Repeated Stretch and Recoil of the Substratum," Exp. Cell Res., 127, pp. 470-474.
52. Dartsch, P. C., and Hämmerle, H., 1986, "Orientation Response of Arterial Smooth Muscle Cells to Mechanical Stimulation," Eur. J. Cell Biol., 41, pp. 339-346.
53. Ives, C. L., Eskin, S. G., and McIntire, L. V., 1986, "Mechanical Effects on Endothelial Cell Morphology: In Vitro Assessment," In Vitro Cell Dev. Biol., 22, pp. 500-507.
54. Kanda, K., and Matsuda, T., 1994, "Mechanical Stress-Induced Orientation and Ultrastructural Change of Smooth Muscle Cells Cultured in Three-Dimensional Collagen Lattices," Cell Transplant. 3, pp. 481-492.