Depolarization increases pyroglutamyl aminopeptidase activity in rat frontal cortex synaptosomes. Inhibitory effect of aminoglycoside antibiotics neomycin and kanamycin;Los antibioticos aminoglucosidos neomicina y kanamicina inhiben el incremento de actividad piroglutamato aminopeptidasa obtenido tras despolarizacion de sinaptosomas de corteza frontal de rata

Revista de Neurologia

Volumn 30, Issue 11, 2000, Pages 1022-1026

  Ramirez Exposito Ma J ^a   Martinez Martos J M ^a   Mayas, Ma D ^a   Tsuboyama, G ^b   Prieto, I ^a   Arechaga, G ^a   Ramirez M ^a  

^a UNIVERSITY OF JAÉN   (Spain)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Aminoglycosides; Calcium channels; Depolarization; Frontal cortex; Kanamycin; Neomycin; Pyroglutamyl aminopeptidase; Synaptosomes; Thyrotrophin releasing hormone

Indexed keywords

5 OXOPROLYL PEPTIDASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; INOSITOL 4,5 DIPHOSPHATE; INOSITOL PHOSPHATE; KANAMYCIN; NEOMYCIN; NEUROTRANSMITTER; POTASSIUM CHLORIDE; PROTIRELIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANIMAL CELL; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FRONTAL CORTEX; MALE; MEMBRANE DEPOLARIZATION; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; RAT; ANIMAL; DRUG EFFECT; FRONTAL LOBE; SYNAPTOSOME; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM CHANNELS; FRONTAL LOBE; KANAMYCIN; MALE; NEOMYCIN; PYROGLUTAMYL-PEPTIDASE I; RATS; RATS, WISTAR; SYNAPTOSOMES; THYROTROPIN-RELEASING HORMONE;

EID: 0034210192     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3011.2000049     Document Type: Article

References (49)

1. De Ceballos M. Péptidos neurotransmisores. En Andreu D, Rivas L, eds. Péptidos en biología y biomedicina. Madrid: Consejo Superior de Investigaciones Científicas; 1997. p. 461-78.
2. Mora F. Neuropéptidos y funciones cerebrales: una perspectiva crítica. En Blázquez E, Tamarit J, eds. Péptidos reguladores gastrointestinales y recepción y transducción de señales generadas por hormonas polipeptídicas, tiroideas y esteroideas. Madrid: Fundación Ramón Areces; 1992. p. 403-8.
3. Hôkfelt Y, Johansson O, Ljungdhal A, Lundberg JM, Schultzberg M. Peptidergic neurones. Nature 1980; 184: 515-21.
4. Miller RJ. Multiple calcium channels and neuronal function. Science 1987; 235: 46-52.
5. Smith SJ, Augustine GJ. Calcium ions, active zones and synaptic transmitter release. Trends Neurosci 1988; 11: 458-64.
6. Allbritton NL, Meyer T. Localized calcium spikes and propagating calcium waves. Cell Calcium 1993; 14: 691-7.
7. Iversen LL, Iversen SA, Bloom FE, Vargo T, Guillenmin R. Release of enkephalin from globus pallidus in vitro. Nature 1978; 271: 679-81.
8. + evoked release of met-enkephalin from rat striatum in vitro: effect of putative neurotransmitters and morphine. Naunyn Schmiedebergs Arch Pharmacol 1980; 310: 203-9.
9. Cesselin F, Bourgoin S, Artaud F, Hamon M. Basic and regulatory mechanisms of in vitro release of Met-enkephalin from the dorsal zone of rat spinal cord. J Neurochem 1984; 43: 763-73.
10. Bayon A, Shoemaker WJ, Lugo L, Azad R, Ling N, Drucker-Colin RR, et al. In vivo release of enkephalin from the globus pallidus. Neurosci Lett 1981; 24: 65-70.
11. Maidment NT, Brumbaugh DR, Rudolph VR, Erdelyi E, Evans CJ. Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo. Neuroscience 1989; 33: 549-57.
12. You ZB, Herrera-Marschitz M, Nylander I, Goiny M, O'Connor WT, Ungerstedt U, et al. The striatonigral dynorphin pathway of the rat studies by in vivo microdialysis. II. Effects of dopamine D1 and D2 receptor agonists. Neuroscience 1994; 63: 427-34.
13. Kostyuk PG, Tepikin AV. Calcium signals in nerve cell. News Physiol Sci 1991; 6: 6-10.
14. Bertolino M, Llinás RR. The central role of voltage-activated and receptor-operated calcium channels in neuronal cells. Annu Rev Pharmacol Toxicol 1992; 32: 399-421.
15. Trifaro JM, Vitale ML. Cytoskeleton dynamics during neurotransmitter release. Trends Neurosci 1993; 16: 466-72.
16. Peinado JM, Martínez-Martos JM, Afailal M, Iribar C. Canales de calcio y mecanismos de liberación de neurotransmisores en el sistema nervioso central. Folia Neuropsiquiatrica 1996; 31: 123-39.
17. Barrett AJ, Rowlings ND, Woesnner JF. Handbook of proteolytic enzymes. London: Academic Press; 1998.
18. Sattin A. The role of TRH and related peptides in the mechanism of action of ECT. J ECT 1999; 15: 76-92.
19. Bauer K. Adenohypophyseal degradation of thyrotropin releasing hormone regulated by thyroid hormones. Nature 1987; 330: 375-7.
20. Simard M, Pekary AE, Smith VP, Hershman JM. Thyroid hormone modulation of TRH precursor levels in rat hypothalamus, pituitary, thyroid and blood. Peptides 1989; 10: 145-55.
21. Mudge AW, Fellows RE. Bovine pituitary pyrolidonecarboxylyl peptidase. Endocrinology 1973; 93: 1428-34.
22. Browne P, O'Cuinn G. An evaluation of the role of a pyroglutamate aminopeptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl aminopeptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro. Eur J Biochem 1983; 137: 75-87.
23. Lauffart B, McDermott JR, Biggins JA, Gibson AM, Mantle D. Purification and characterization of pyroglutamyl aminopeptidase from human cerebral cortex. Biochem Soc Trans 1989; 17: 207-8.
24. O'Connor B, O'Cuinn G. Localization of a narrow-specificity thyroliberin-hydrolysing pyroglutamate aminopeptidase in synaptosomal membranes of guinea-pig brain. Eur J Biochem 1984; 144: 271-8.
25. Elmore MA, Griffiths EC, O'Connor B, O'Cuinn G. Further characterization of the substrate specificity of TRH hydrolysing pyroglutamate aminopeptidase from guinea-pig brain. Neuropeptides 1986; 15: 31-6.
26. Taylor WL, Dixon JE. Characterization of a pyroglutamate aminopeptidase from rat serum that degrades thyrotropin-releasing hormone. J Biol Chem 1978; 253: 6934-40.
27. Bauer K, Nowak P. Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond. Eur J Biochem 1979; 99: 239-46.
28. Bauer K, Nowak P, Kleinkauf H. Specificity of a serum peptidase hydrolysing thyroliberin at the pyroglutamyl-histidine bond. Eur J Biochem 1981; 118: 173-6.
29. Bauer K. Purification and characterization of the thyrotropin-releasing-hormone-degrading ectoenzyme. Eur J Biochem 1981; 224: 387-96.
30. De Gortari P, Fernández-Guardiola A, Martínez A, Cisneros M, Joseph-Bravo P. Changes in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindling. Brain Res 1995; 679: 144-50.
31. Suárez-Kurtz G, Reuben JP. Effects of neomycin on calcium channel currents in clonal GH3 pituitary cells. Pflugers Arch 1987; 410: 517-23.
32. Martínez-Martos JM, Iribar MC, Peinado JM. Evoked GABA release is not mediated by N-type VDCC in the frontal cortex of awake rats: effects of neomycin. Brain Res Bull 1997; 43: 441-5.
33. Whittaker VP. The synaptosome. In Lajtha A, ed. Handbook of neurochemistry. New York: Plenum Press; 1984. p. 184-203.
34. Schwabe C, McDonald JK. Demonstration of a pyroglutamyl residue at the N-terminus of the B-chain of porcine relaxin. Biochem Biophys Res Commun 1977; 74: 1501-4.
35. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50.
36. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
37. Mayas MD, Martínez-Martos JM, Ramírez-Expósito MJ, García MJ, Tsuboyama G, Prieto I, et al. Estudio in vitro del efecto del etanol sobre la actividad piroglutamato aminopeptidasa en sinaptosomas de ratón en condiciones basales y despolarizantes. Rev Neurol 2000; 30: 128-31.
38. Perrier ML, Scatton B, Benavides J. Dihydropyridine- and omega-conotoxin-resistant, neomycin-sensitive calcium channels mediate the depolarization-induced increase in internal calcium levels in cortical slices from immature rat brain. J Pharmacol Exp Ther 1992; 261: 324-30.
39. Keith RA, Mangano RJ, Defeo PA, Horn MB, Salama AI. Actions of neomycin on neuronal L-, N- and non-L/non-N type voltage-sensitive calcium channels responses. J Mol Neurosci 1992; 3: 147-54.
40. Wagner JA, Snowman AM, Biswas A, Olivera BH, Snyder SH. ω-conotoxin GVIA binding to a high-affinity receptor in brain; characterization calcium sensitivity and solubilization. J Neurosci 1991; 8: 3354-9.
41. Yamada K, Teraoka T, Morita S, Hasegawa T, Nabeshima T. Neuropharmacological characterization of voltage-sensitive calcium channels: possible existence of neomycin-sensitive, omega-conotoxin GVIA- and dihydropyridines-resistant calcium channels in the rat brain. Jpn J Pharmacol 1993; 63: 423-32.
42. Pichler M, Waing Z, Grabner-Weiss C, Reimer D, Hering S, Grabner M, et al. Block of P/Q type calcium channels by therapeutic concentrations of aminoglycoside antibiotics. Biochemistry 1996; 35: 14659-64.
43. McBurney RN, Daly D, Fischer JB, Hu LY, Subbarao K, Knapp J, et al. New CNS-specific calcium antagonists. J Neurotrauma 1992; 9: 531-43.
44. Meinwald J, Eisner T. The chemistry of phyletic dominance. Proc Natl Acad Sci USA 1995; 92: 14-8.
45. Bergquist F, Jonason J, Pileblad E, Nissbrandt H. Effects of local administration on L-, N-, and P/Q-type calcium channel blockers on spontaneous dopamine release in the striatum and the substantia nigra: a microdialysis study in rat. J Neurochem 1998; 70: 1532-40.
46. Randall AD, Tsien RW. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology 1997; 36: 879-93.
47. Tottene A, Moretti A, Pietrobon D. Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons. J Neurosci 1996; 16: 6353-63.
48. Mack WM, Zimanyi I, Pessah IN. Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum. J Pharmacol Exp Ther 1992; 262: 1028-37.
49. Chauan VP. Phosphatidylinositol 4,5-bisphosphate stimulates protein-kinase C-mediated phosphorylation of soluble brain proteins. Inhibition by neomycin. FEBS Lett 1990; 272: 99-102.