Mechanism of action in a 4,5-diarylpyrrole series of selective cyclo-oxygenase-2 inhibitors

Free Radical Biology and Medicine

Volumn 28, Issue 11, 2000, Pages 1638-1641

  Zoete, Vincent ^a   Maglia, Francesca ^b   Rougée, Michel ^c   Bensasson, René V ^c  

^a UNIV LILLE   (France)

^b UNIVERSITY OF CATANIA   (Italy)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

4,5 diarrylpyrroles; Energy of the highest occupied molecular orbital lipophilicity Cyclooxygenase 2 and 1 inhibitions; Free radicals

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PYRROLE DERIVATIVE;

ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; ENERGY; INFLAMMATION; LIPOPHILICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ISOENZYMES; OXIDATION-REDUCTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0034209779     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00278-1     Document Type: Article

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