Protease nexin-2/amyloid β-protein precursor regulates factor VIIa and the factor VIIa-tissue factor complex

Thrombosis Research

Volumn 99, Issue 3, 2000, Pages 267-276

  Mahdi, Fakhri ^a   Rehemtulla, Alnawaz ^a   Van Nostrand, William E ^b   Bajaj, S Paul ^c   Schmaier, Alvin H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c Hematology Oncology Consultants   (United States)

Author keywords

Antithrombin; Factor VIIa tissue factor; Factor Xa; Kunitz protease inhibitor; Protease nexin 2 amyloid protein precursor

Indexed keywords

AMYLOID BETA PROTEIN; APROTININ; BLOOD CLOTTING FACTOR 7A; NEXIN 2; PROTEINASE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL REACTION KINETICS; HOMEOSTASIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

AMYLOID BETA-PROTEIN PRECURSOR; ANTICOAGULANTS; ANTITHROMBIN III; CARRIER PROTEINS; CHROMATOGRAPHY, GEL; FACTOR VIIA; FACTOR X; HEPARIN; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN;

EID: 0034209755     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00245-0     Document Type: Article

References (31)

1. Rosenberg R.D., Bauer K.A. The heparin-antithrombin system. a natural anticoagulant mechanism Colman R.W., Hirsh J., Marder V.J., Salzman E.W. Hemostasis and Thrombosis. Basic Principles and Clinical Practice:1994;837-860 J.B. Lippincott Co, Philadelphia.
2. Tollefsen D.M., Majerus D.W., Blank M.K. Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma. J Biol Chem. 257:1982;2162-2169.
3. Baker J.B., Low D.A., Simmer R.L., Cunningham D.D. Protease-nexin. a cellular component that links thrombin and plasminogen activator and mediates their binding to cells Cell. 21:1980;37-45.
4. Girard T.J., Warren L.A., Novotny W.F., Likert K.M., Brown S.G., Miletich J.P., Broze G.J. Jr. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature. 338:1989;518-520.
5. Broze G.J. Jr., Girard T.J., Novotny W.F. Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry. 29:1989;7539-7546.
6. Huang Z.-F., Wun T.-C., Broze G.J. Jr. Kinetics of factor Xa inhibition by tissue factor pathway inhibitor. J Biol Chem. 268:1993;26950-26955.
7. Lawson J., Butenas S., Ribarik N., Mann K.G. Complex-dependent inhibition of factor VIIa by antithrombin III and heparin. J Biol Chem. 268:1993;767-770.
8. Rao L.V.M., Rapaport S.I., Hoang A.D. Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood. 81:1993;2600-2607.
9. Van Nostrand W.E., Schmaier A.H., Farrow J.S., Cines D.B., Cunningham D.D. Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein. Biochem Biophys Res Commun. 175:1991;15-21.
10. Van Nostrand W.E., Schmaier A.H., Farrow J.S., Cunningham D.D. Protease nexin-II (amyloid beta-protein precursor). a platelet alpha-granule protein Science. 248:1990;745-748.
11. Smith R.P., Higuchi D.A., Broze G.J. Jr. Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. Science. 248:1990;1126-1128.
12. Wuillemin W.A., Minnema M., Meijers J.C.M., Roem D., Eerenberg A.J.M., Nuijens J.H., ten Cate H., Hack C.E. Inactivation of factor XIa in human plasma assessed by measuring factor XIa- protease inhibitor complexes. major role for C1-inhibitor Blood. 85:1995;1517-1526.
13. Schmaier A.H., Dahl L.D., Rozemuller A.J.M., Roos R.A.C., Wagner S.L., Chung R., Van Nostrand W.E. Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa. J Clin Invest. 92:1993;2540-2545.
14. Schmaier A.H., Dahl L.D., Hasan A.A.K., Cines D.B., Bauer K.A., Van Nostrand W.E. Factor IXa inhibition by protease nexin-2/amyloid beta-protein precursor on phospholipid vesicles and cell membranes. Biochemistry. 34:1995;1171-1178.
15. Mahdi F., Van Nostrand W.E., Schmaier A.H. Protease nexin-2/amyloid beta-protein precursor inhibits factor Xa in the prothrombinase complex. J Biol Chem. 270:1995;23468-23474.
16. Dennis M.S., Lazarus R.A. Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected from libraries by phage display. J Biol Chem. 269:1994;22129-22136.
17. Dennis M.S., Lazarus R.A. Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection. J Biol Chem. 269:1994;22137-22144.
18. Van Nostrand W.E., Wagner S.L., Farrow J.S., Cunningham D.D. Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor. J Biol Chem. 265:1990;9591-9594.
19. Wagner S.L., Siegel R.S., Vedick T.S., Raschke W.C., Van Nostrand W.E. High level expression, purification, and characterization of the Kunitz-type protease inhibitor domain of protease nexin-2/amyloid beta-protein precursor. Biochem Biophys Res Commun. 186:1992;1138-1145.
20. EGFI. M.S. Thesis. St. Louis, MO: St. Louis University; 1994.
21. Griffith M.J., Breitkreutz L., Trapp H., Breit E., Noyes C.M., Lundblad R.L., Roberts H.R. Characterization of the clotting activities of structurally different forms of activated factor IX. Enzymatic properties of normal human factor IXa alpha, factor IXa beta, and activated factor IX Chapel Hill. J Clin Invest. 75:1985;4-10.
22. Sabharwal A.K., Birktoft J.J., Gorka J., Wildgoose P., Petersen L.C., Bajaj S.P. High affinity Ca(2+)-binding site in the serine protease domain of human factor VIIa and its role in tissue factor binding and development of catalytic activity. J Biol Chem. 270:1995;15523-15530.
23. Ruf W., Miles D.J., Rehemtulla A., Edginton T.S. Mutational analysis of receptor and cofactor function of tissue factor. Methods Enzymol. 222:1993;209-223.
24. Bieth J.G. In vivo significance of kinetic constants of protein proteinase inhibitors. Biochem Med. 32:1984;387-397.
25. Gigli I., Mason J.W., Colman R.W., Austin F.W. Interaction of plasma kallikrein with the C1 inhibitor. J Immunol. 104:1970;574-581.
26. Ruf W., Rehemtulla A., Edgington T.S. The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. J Biol Chem. 266:1991;10294-10299.
27. Huang Q., Neuenschwander P.F., Rezaie A.R., Morrissey J.H. Substrate recognition by tissue factor-factor VIIa. Evidence for interaction of residues Lys165 and Lys166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X. J Biol Chem. 271:1996;21752-21757.
28. Broze G.J. Jr., Miletich J.P. Isolation of the tissue factor inhibitor produced by HepG2 hepatoma cells. Proc Natl Acad Sci USA. 84:1987;1886-1890.
29. Rojkjaer R., Schmaier A.H. Regulation of kallikrein, factor XIa and factor XIIa activity on endothelial cell membranes. Thromb Haemost. Suppl:1999;33.
30. Van Nostrand W.E., Schmaier A.H., Siegel R.S., Wagner S.L., Raschke W.C. Enhanced plasmin inhibition by a reactive center lysine mutant of the Kunitz-type protease inhibitor domain of the amyloid beta-protein precursor. J Biol Chem. 270:1995;22827-22830.
31. Annich G., White T., Damm D., Zhao Y., Mahdi F., Meinhardt J., Rebello S., Lucchesi B., Bartlett R.H., Schmaier A.H. Recombinant Kunitz protease inhibitory domain of the amyloid β- protein precursor as an anticoagulant in venovenous extracorporeal circulation in rabbits. Thromb Haemost. 82:1999;1474-1481.