Ionic polysaccharide hydrogels via the Passerini and Ugi multicomponent condensations: Synthesis, behavior and solid-state NMR characterization

Biomacromolecules

Volumn 1, Issue 2, 2000, Pages 259-267

  De Nooy, Arjan E J ^a   Capitani, Donatella ^b   Masci, Giancarlo ^a   Crescenzi, Vittorio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS LINKING REAGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; POLYSACCHARIDE;

ARTICLE; CARBOHYDRATE ANALYSIS; CHEMISTRY; HYDROGEL; METHYLATION; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; PH; SYNTHESIS;

CARBOHYDRATE SEQUENCE; CROSS-LINKING REAGENTS; HYDROGELS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; POLYSACCHARIDES;

EID: 0034209005     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm005517h     Document Type: Article

References (26)

1. Kudela, V. Hydrogels. In Encyclopedia of Polymer Science and Engineering, 2nd ed.; Mark, H. F., Bikales, N. M., Overberger, C. C., Menges, G., Eds.; Wiley-Interscience: New York, 1987; Vol. 7, p 783.
2. Park, K.; Shalaby, W. S. W.; Park, H. Chemical Gels. In Biodegradable Hydrogels for Drug Delivery; Technomic Publishing Company: Lancaster, PA, 1993; p 67.
3. Park, H.; Park, K. Hydrogels in Bioapplications. In Hydrogels and Biodegradable Polymers for Bioapplications; Ottenbrite, R. M., Huang, S. J., Park, K., Eds.; ACS Symposium Series 629: Washington, DC, 1996; p 2.
4. van Dijk-Wolthuis, W. N. E.; Hoogeboom, J. A. M.; van Steenbergen, M. J.; Tsang, S. K. Y.; Hennink, W. E. Macromolecules 1997, 30, 4639.
5. Rubinstein, A.; Nakar, D.; Sintov, A. Pharm. Res. 1992, 9, 276.
6. Kuijpers, A. J.; Engbers, G. H. M.; van Wachem, P. B.; Krijgsveld, J.; Zaat, S. A. J.; Dankert, J.; Feijen, J. J. Controlled Release 1998, 53, 235-247.
7. de Nooy, A. E.,; Masci, G.; Crescenzi, V. Macromolecules 1999, 32, 1318.
8. For a review, see: Ugi, I.; Lohberger, S.; Karl. R. The Passerini and Ugi Reactions. In Comprehensive Organic Synthesis; Trost B. M., Heathcock, C. H., Eds.; Pergamon: Oxford, 1991; Vol. 2; pp 1083-1107.
9. König, S.; Ugi, I. Z. Naturforsch. 1991, 46b, 1261.
10. 15N CP-MAS NMR for the characterization of cross-linked polymers, see: Law, R. V.; Sherrington, D. C. In Solid-state NMR of Polymers; Ando, I., Asakura, T., Eds.; Elsevier: Amsterdam, 1998; Vol. 84, pp 510-588.
11. de Nooy, A. E. J.; Besemer, A. C.; van Bekkum, H. Carbohydr. Res. 1995, 269, 89.
12. de Nooy, A. E. J.; Ron, V.; Masci, G.; Dentini, M.; Crescenzi, V. Carbohydr. Res., in press.
13. de Nooy, A. E. J.; Besemer, A. C.; van Bekkum, H. Tetrahedron 1995, 51, 8023.
14. Voelkel, R. In Solid State NMR of Polymers; Mathias, L. J., Ed.; Plenum Press: New York, 1988; pp 233-244.
15. Harris, R. K. In Multinuclear Magnetic Resonance in Liquids and Solids - Chemical Application; Granger, P., Harris, R. K., Eds.; NATO ASI Series 322; Kluwer, Dordrecht, The Netherlands, 1988; p 291.
16. Wu, X.; Zilm, K. W. J. Magn. Reson. 1993, A102, 205.
17. Wu, X.; Zilm, K. W. J. Magn. Reson. 1993, A104, 119.
18. Opella, S. J.; Frey, M. H. J. Am. Chem. Soc. 1979, 101, 5854.
19. Verraest, D. L.; Peters, J. A.; Batelaan, J. G.; van Bekkum, H. Carbohydr. Res. 1995, 271, 101.
20. Ugi, I.; Marquarding, D.; Urban, R. In Chemistry and Biochemistry of Amino Acids, Peptides and Proteins; Weinstein, B., Ed.; Marcel Dekker: New York, 1982; Vol. 6, p 245.
21. Capitani, D.; Segre, A. L.; Porro, F Carbohydr. Polym., in press.
22. Kalinowski, H. O.; Berger, S.; Braun, S. Carbon-13 NMR Spectroscopy; John Wiley & Sons Lt,; New York, 1988.
23. Capitani, D.; Del Nobile, M. A.; Mensitieri, G.; Sannino, A.; Segre, A. L. Macromolecules, 2000, 30, 430.
24. Voelkel, R. Angew. Chem., Int. Ed. 1988, 27, 1468.
25. McBrierty, V.; Packer, K. J. NMR in Solid Polymers; Cambridge University Press: Cambridge, U.K., 1993.
26. Ziegler, T.; Schlömer, R.; Koch, C. Tetrahedron Lett. 1998, 39, 5957-5960.