Cyclodidemniserinol Trisulfate, a Sulfated Serinolipid from the Palauan Ascidian Didemnum guttatum That Inhibits HIV-1 Integrase

Organic Letters

Volumn 2, Issue 11, 2000, Pages 1605-1607

  Mitchell, Scott S ^a   Rhodes, Denise ^b   Bushman, Frederic D ^b   Faulkner, D John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOLOGICAL FACTOR; DNA TOPOISOMERASE; ENZYME INHIBITOR; INTEGRASE; INTEGRASE INHIBITOR; LIPID; PROPANEDIOL DERIVATIVE; SERINOL; SULFATE;

ANIMAL; ARTICLE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CYTOMEGALOVIRUS; DRUG ANTAGONISM; ENZYMOLOGY; ISOLATION AND PURIFICATION; LIPID METABOLISM; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; UROCHORDATA;

ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL FACTORS; CYTOMEGALOVIRUS; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; LIPID METABOLISM; LIPIDS; MARINE BIOLOGY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROPYLENE GLYCOLS; SULFATES; UROCHORDATA;

EID: 0034203978     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol005866o     Document Type: Article

References (9)

1. Coffin, J. M.; Hughes, S. H.; Varmus, H. E. Retroviruses: Cold Spring Harbor Laboratory Press: Cold Spring Harbor. 1997; p 834.
2. See, for example: (a) Reddy, M. V. R.; Rao, M. R.; Rhodes, D.; Hansen, M.; Rubins, K.; Bushman, F.; Venkateswarlu, Y.; Faulkner, D. J. J. Med. Chem. 1999, 42, 1901-1907. (b) Carlson, H. A.; Masukawa, K. M.; Rubins, K.; Bushman, F. D.; Jorgensen, W. L.; Lins, R. D.; Briggs, J. M.; McCammon, J. A. J. Med. Chem., in press.
3. See, for example: (a) Reddy, M. V. R.; Rao, M. R.; Rhodes, D.; Hansen, M.; Rubins, K.; Bushman, F.; Venkateswarlu, Y.; Faulkner, D. J. J. Med. Chem. 1999, 42, 1901-1907. (b) Carlson, H. A.; Masukawa, K. M.; Rubins, K.; Bushman, F. D.; Jorgensen, W. L.; Lins, R. D.; Briggs, J. M.; McCammon, J. A. J. Med. Chem., in press.
4. Qureshi, A.; Faulkner, D. J. Tetrahedron 1999, 55, 8323-8330.
5. González, N.; Rodriguez, J.; Jiménez, C. J. Org. Chem. 1999, 64, 5705-5707.
6. Counterscreens were carried out by assaying inhibition of the topoisomerase enzyme of Molluscum contagiosum virus (MCV). Assays monitored the breaking and rejoining of a DNA strand characteristic of type 1B topoisomerases and were carried out in a microtiter plate format.
7. Albertini, E.; Barco, A., Benetti, S.; De Risi, C.; Polini, G. P.; Zanirato, V. Tetrahedron Lett. 1997, 38, 681-684.
8. Hansen, M. T. S.; Carteau, S.; Hoffmann, C.; Li, L.; Bushman, F. In Genetic Engineering. Principles and Methods; Setlow, J. K., Ed.; Plenum Press: New York, 1998; pp 41-62.
9. Craigie, R.; Mizuuchi, K.; Bushman, F. D.; Engelman, A. Nuc. Acids Res. 1991, 19, 2729-2734.