GnRH antagonist inhibition of gonadotropin and steroid secretion in boars in vivo and steroid production in vitro

Journal of Animal Science

Volumn 78, Issue 6, 2000, Pages 1591-1597

  Zanella, E L ^b,c   Lunstra, D D ^a   Wise, T H ^a   Kinder, J E ^b   Ford, J J ^a  

^a U S MEAT ANIMAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c EMBRAPA CERRADOS   (Brazil)

Author keywords

Pituitary; Porcine; Testes; Testosterone

Indexed keywords

SUIDAE; SUS SCROFA;

CETRORELIX; CHORIONIC GONADOTROPIN; DRUG DERIVATIVE; ESTRONE; FOLLITROPIN; GONADORELIN; HORMONE ANTAGONIST; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL; ARTICLE; BLOOD; CASTRATION; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; SWINE; TESTIS;

ANIMALS; CASTRATION; CELLS, CULTURED; CHORIONIC GONADOTROPIN; ESTRONE; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; LUTEINIZING HORMONE; MALE; SWINE; TESTIS; TESTOSTERONE;

EID: 0034201762     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2000.7861591x     Document Type: Article

References (45)

1. Allrich, R. D., R. K. Christenson, J. J. Ford, and D. R. Zimmerman. 1983. Pubertal development of the boar: Age-related changes in testicular morphology and in vitro production of testosterone and estradiol-17β. Biol. Reprod. 28:902-909.
2. Aten, R. F., J. J. Ireland, C. W. Weems, and H. R. Behrman. 1987. Presence of gonadotropin-releasing hormone-like proteins in bovine and ovine ovaries. Endocrinology 120:1727-1733.
3. Ayalon, D., Y. Farhi, A. M. Comaru-Schally, A. V. Schally, N. Eckstein, I. Vagman, and R. Limor. 1993. Inhibitory effect of a highly potent antagonist of LH releasing hormone (SB-75) on the pituitary gonadal axis in the intact and castrated rat. Neuroendocrinology 58:153-159.
4. Behrman, H. R., S. L. Preston, and A. K. Hall. 1980. Cellular mechanism of the antigonadotropic action of luteinizing hormone-releasing hormone in the corpus luteum. Endocrinology 107:656-664.
5. Borg, K. E., D. D. Lunstra, and R. K. Christenson. 1993. Semen characteristics, testicular size, and reproductive hormone concentrations in mature Duroc, Meishan, Fengjing, and Minzhu boars. Biol. Reprod. 49:515-521.
6. Brooks, J., P. L. Taylor, P. T. Saunders, K. A. Eidne, W. J. Struthers, and A. S. McNeilly. 1993. Cloning and sequencing of the sheep pituitary gonadotropin-releasing hormone receptor and changes in expression of its mRNA during the estrous cycle. Mol. Cell. Endocrinol. 94:R23-R27.
7. Brown, J. L., and J. J. Reeves. 1983. Absence of specific luteinizing hormone releasing hormone receptors in ovine, bovine and porcine ovaries. Biol. Reprod. 29:1179-1182.
8. Christensen, A. K. 1975. Leydig cells. In: D. W. Hamilton and R. O. Greep (Ed.) Handbook of Physiology, Vol. V, Male Reproduction System, pp 57-94. American Physiological Society, Washington, DC.
9. Clarke, I. J., and J. T. Cummins. 1982. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111:1737-1739.
10. Clayton, R. N., A. R. Solano, A. Garcia-Vela, M. L. Dufau, and K. J. Catt. 1980. Regulation of pituitary receptors for gonadotropin-releasing hormone during the rat estrous cycle. Endocrinology 107:699-706.
11. Corrigan, A. Z., L. M. Bilezikjian, R. S. Carroll, L. N. Bald, C. H. Schmelzer, B. M. Fendly, A. J. Mason, W. W. Chin, R. H. Schwall, and W. Vale. 1991. Evidence for an autocrine role of activin B within rat anterior pituitary cultures. Endocrinology 128:1682-1684.
12. Costa, O., J. J. Mulchahey, and J. E. Blalock. 1990. Structure and function of luteinizing hormone-releasing hormone (LHRH) receptors on lymphocytes. Prog. Neuroendocrinimmunol. 3:55-60.
13. Currie, A. J., H. M. Fraser, and R. M. Sharpe. 1981. Human placental receptors for luteinizing hormone releasing hormone. Biochem. Biophys. Res. Commun. 99:332-338.
14. Emons, G., V. Müller, O. Ortmann, and K. D. Schulz. 1998. Effects of LHRH-analogues on mitogenic signal transduction in cancer cells. J. Steroid. Biochem. Mol. Biol. 65:199-206.
15. FASS. 1999. Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (First Rev. Ed.). Federation of Animal Science Societies, Savoy, IL.
16. Fekete, M., T. W. Redding, A. M. Comaru-Schally, J. E. Pontes, R. W. Connelly, G. Srkalovic, and A. V. Schally. 1989. Receptors for luteinizing hormone-releasing hormone, somatostatin, prolactin, and epidermal growth factors in rat and human prostate cancers and in benign prostate hyperplasia. Prostate 14:191-208.
17. Ford, J. J., R. K. Christenson, and R. R. Maurer. 1980. Serum testosterone concentrations in embryonic and fetal pigs during sexual differentiation. Biol. Reprod. 23:583-587.
18. Ford, J. J., and B. D. Schanbacher. 1977. Luteinizing hormone secretion and female lordosis behavior in male pigs. Endocrinology 100:1033-1038.
19. Hazum, E., and A. Nimrod. 1982. Photoaffinity-labeling and fluorescence-distribution studies of gonadotropin-releasing hormone receptors in ovarian granulosa cells. Proc. Natl. Acad. Sci. USA 79:1747-1750.
20. Hsueh, A. J. W., and G. F. Erickson. 1979. Extra-pituitary inhibition of testicular function by luteinizing hormone releasing hormone. Nature (Lond.) 281:66-67.
21. Hsueh, A. J. W., and P. C. B. Jones. 1981. Extra-pituitary actions of gonadotropin-releasing hormone. Endocr. Rev. 2:437-461.
22. Ireland, J. J., R. F. Aten, and H. R. Behrman. 1988. GnRH-like proteins in cows: Concentrations during corpora lutea development and selective localization in granulosal cells. Biol. Reprod. 38:544-550.
23. Kakar, S. S., L. C. Musgrove, D. C. Devor, J. C. Sellers, and J. D. Neill. 1992. Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor. Biochem. Biophys. Res. Commun. 189:289-295.
24. Kakar, S. S., C. H. Rahe, and J. D. Neill. 1993. Molecular cloning, sequencing, and characterizing the bovine receptor for gonadotropin releasing hormone (GnRH). Domest. Anim. Endocrinol. 10:335-342.
25. Kartun, K., and N. B. Schwartz. 1987. Effects of potent antagonist to gonadotropin-releasing hormone on male rats: Luteinizing hormone is suppressed more than follicle stimulating hormone. Biol. Reprod. 36:103-108.
26. Krystek, S. R., Jr., J. A. Dias, J. L. W. Reichert, Jr., and T. T. Andersen. 1985. Prediction of antigenic sites in follicle-stimulating hormones: Difference profiles enhance antigenicity prediction methods. Endocrinology 117:1125-1131.
27. Li, M. D., G. J. Macdonald, and J. J. Ford. 1997. Breed differences in expression of inhibin/activin subunits in porcine anterior pituitary glands. Endocrinology 138:712-718.
28. Li, M. D., G. J. Macdonald, T. Wise, and J. J. Ford. 1998. Positive association between expression of follicle stimulating hormone-beta and activin betaB-subunit genes in boars. Biol. Reprod. 59:978-982.
29. Littell, R. C., G. A. Milliken, W. W. Stroup, and R. D. Wolfinger. 1996. SAS System for Mixed Models. SAS Institute, Inc., Cary N.C.
30. Lunstra, D. D., J. J. Ford, J. Klindt, and T. H. Wise. 1997. Physiology of the Meishan boar. In: G. R. Foxcroft, R. D. Geisert, and C. Doberska (Ed.) Control of Pig Reproduction V. J. Reprod. Fertil. (Suppl. 52):181-193.
31. Malvey, J., R. Anthony, C. Clay, and T. Nett. 1997. Immunological detection of GnRH receptors in membranes of bovine and ovine pituitary glands and αT3 cells. Biol. Reprod. 56 (Suppl. 1):171 (Abstr.).
32. Mason, A. J., L. M. Berkemeier, C. H. Schmelzer, and R. H. Schwall. 1989. Activin B: Precursor sequences, genomic structure and in vitro activities. Mol. Endocrinol. 3:1352-1358.
33. Millan, M., G. Aguilera, P. C. Wynn, F. A. Mendelsohn, and K. J. Catt. 1986. Autoradiographic localization of brain receptors for peptide hormones: angiotensin II, corticotropin-releasing factor, and gonadotropin-releasing hormone. Methods Enzymol. 124:590-606.
34. Perrin, M. H., L. M. Bilezikjian, C. Hoeger, C. J. Donaldson, J. Rivier, Y. Haas, and W. W. Vale. 1993. Molecular and functional characterization of GnRH receptors cloned from rat pituitary and a mouse pituitary tumor cell line. Biochem. Biophys. Res. Commun. 191:1139-1144.
35. Pieper, D. R., J. S. Richards, and J. C. Marshall. 1981. Ovarian gonadotropin-releasing hormone (GnRH) receptors: characterization, distribution, and induction by GnRH. Endocrinology 108:1148-1155.
36. Pinski, J., T. Yano, K. Szepeshazi, K. Groot, and A. V. Schally. 1993. Recovery of pituitary-gonadal function in male rats after long-term suppression induced by a single injection of microcapsules of LH-RH antagonist Cetrorelix (SB-75). J. Androl. 14:164-169.
37. SAS. 1985. SAS User's Guide: Statistics (5th Ed.). SAS Inst. Inc., Cary, NC.
38. Schally, A. V., A. Arimura, A. J. Kastin, H. Matsuo, Y. Baba, T. W. Redding, R. M. G. Nair, L. Debeljuk, and W. F. White. 1971. Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones. Science (Wash DC) 173:1036-1038.
39. Trout, W. E., J. H. Killen, R. K. Christenson, B. D. Schanbacher, and J. J. Ford. 1992. Effects of weaning on concentrations of inhibin in follicular fluid and plasma of sows. J. Reprod. Fertil. 94:107-114.
40. Tsutsumi, M., W. Zhou, R. P. Millar, P. L. Mellon, J. L. Roberts, C. A. Flanagan, K. Dong, B. Gillo, and S. C. Sealfon. 1992. Cloning and functional expression of mouse gonadotropin-releasing hormone receptor. Mol. Endocrinol. 6:1163-1169.
41. Weesner, G. D., and R. L. Matteri. 1994. Rapid communication: Nucleotide sequence of luteinizing hormone-releasing hormone (LHRH) receptor cDNA in the pig pituitary. J. Anim. Sci. 72:1911.
42. Wise, T., D. D. Lunstra, and J. J. Ford. 1996. Differential pituitary and gonadal function of Chinese Meishan and European White Composite boars: Effect of gonadotropin-releasing hormone stimulation, castration, and steroid feedback. Biol. Reprod. 54:146-153.
43. Wise, T., E. L. Zanella, D. D. Lunstra, and J. J. Ford. 2000. Relationships of gonadotropins, testosterone, and cortisol in response to GnRH and GnRH antagonist in boars selected for high and low follicle-stimulating hormone levels. J. Anim. Sci. 78:1577-1590.
44. Zanella, E. L., J. J. Ford, T. Wise, and D. L. Hamernik. 1996. Pituitary relationship of gonadotropins and messenger ribonucleic acid for gonadotropin subunits in White Composite and Meishan boars. Biol. Reprod. 54:154-159.
45. Ziecik, A. J., K. L. Esbenshade, and J. H. Britt. 1989. Effects of a gonadotrophin-releasing hormone antagonist on gonadotrophin secretion and gonadal development in neonatal pigs. J. Reprod. Fertil. 87:281-289.