Chloroquine: A multipotent iInhibitor of human platelets in vitro

Thrombosis Research

Volumn 98, Issue 5, 2000, Pages 411-421

  Nosál', Rado ^a   Jančinová, Viera ^a   Danihelová, Edita ^b  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Inst Haematol and Transfusiology   (Slovakia)

Author keywords

Aggregation; Arachidonate cascade; Chloroquine; Histamine; Platelets; Serotonin

Indexed keywords

ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; CALCIMYCIN; CHLOROQUINE; HISTAMINE; MALONALDEHYDE; MEMBRANE PHOSPHOLIPID; PHORBOL MYRISTATE; PHOSPHOLIPASE A2; THROMBIN; ADRENALIN; DIAGNOSTIC AGENT; PHORBOL 13 ACETATE 12 MYRISTATE; SEROTONIN; THROMBOXANE B2; TRITIUM;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; SEROTONIN RELEASE; THROMBOCYTE AGGREGATION; ADULT; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MIDDLE AGED; THROMBOCYTE; TIME;

ADULT; ARACHIDONIC ACID; BLOOD PLATELETS; CALCIMYCIN; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; HUMANS; MALONDIALDEHYDE; MIDDLE AGED; PLATELET AGGREGATION; SEROTONIN; TETRADECANOYLPHORBOL ACETATE; THROMBIN; THROMBOXANE B2; TIME FACTORS; TRITIUM;

EID: 0034195199     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00200-0     Document Type: Article

References (45)

1. Webster L.T. Drugs used in therapy of protozoal infections. Malaria Gilman A.G., Rall T.W., Niess A.S., Taylor P. The Pharmacological Basis of Therapeutics. 8th ed:1990;978-998 Pergamon Press, New York.
2. Prassad R.N., Gunguly N.K., Mahajan R.C. Immunopharmacology of chloroquine. Trans Roy Soc Trop Med Hyg. 81:1987;168-179.
3. DaPrada M., Pletscher A. Accumulation of basic drugs in 5-hydroxytryptamine storage organelles of rabbit platelets. Eur J Pharmacol. 31:1975;179-185.
4. Costa J.L., Fay D.D., Kirk K.L. Quinacrine and other basic amines in human platelets. Subcellular compartmentation and effect on serotonin. Res Comm Chem Pathol Pharmacol. 43:1984;25-42.
5. Bergquist Y., Domeij-Nyberg B. Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma. J Chromatogr. 272:1983;137-148.
6. Nosál' R., Ericsson O., Sjöqvist F., Durišová M. Distribution of chloroquine in human blood fractions. Meth Find Exptl Clin Pharmacol. 10:1988;581-587.
7. Berthand E., Cloitre B., Ticolat R., Bile R.K., Gautier C., Abiyon G.O., Bohui B.Y. Antiaggregation action of chloroquine. Med Trop Mars. 50:1990;143-146.
8. Cummins D., Faint R., Yardumian D.A., Dawling S., Mackie I., Macchin S.J. The in vitro and ex vivo effect of chloroquine sulfate on platelet function. Implication for malaria prophylaxis in patients with impaired haemostasis J Trop Med Hyg. 93:1993;112-115.
9. Jančinová V., Nosál R., Petríková M. On the inhibitory effect of chloroquine on blood platelet aggregation. Thromb Res. 74:1994;495-504.
10. Nosál' R., Jančinová V., Petríková M. Chloroquine inhibits stimulated platelets at the arachidonic acid pathway. Thromb Res. 77:1995;531-542.
11. Joshi U.M., Mehendale H.M. Drug-induced pulmonary phospholipidosis. Comm Toxicol. 3:1989;91-115.
12. Nosál' R. Blood platelets and chloroquine. Platelets. 6:1995;310-316.
13. Jančinová V., Petríková M., Nosál' R. Difference among beta-adrenoceptor blocking drugs in modifying platelet aggregation and arachidonic acid liberation under thrombin stimulation. Thromb Res. 54:1989;687-698.
14. Nosál' R., Petríková M., Jančinová V. Alteration in lipid peroxidation of thrombin-stimulated rat platelets treated with β-adrenoceptor blocking drugs. J Lipid Med. 8:1993;121-132.
15. Nosál' R., Drábiková K., Rekalov V. Current-voltage relationship in isolated mast cells during histamine liberation and membrane fluidization. Inflamm Res. 47:1998;S13-S15.
16. Nosál' R., Jančinová V., Danihelová E. Species differences in the pharmacology of blood platelets. Platelets. 9:1998;419-420.
17. 2-adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin-sensitive G-protein. FEBS Lett. 339:1994;79-83.
18. Gachet C., Cattaneao M., Ohlmann P., Lecchi A., Hechler B., Chevalier J., Cassel D., Manucci P., Cezenave J.P. Purinoceptors on blood platelets. further pharmacological and clinical evidence to suggest the presence of two ADP receptors Br J Haematol. 91:1995;434-444.
19. Ware J.A., Chang J.D. Protein kinase C and its interactions with other serine-threonine kinases. von Bruchhausen F., Walter U. Platelets and Their Functions. Handbook of Experimental Pharmacology, Vol. 126. 1998;247-262 Springer Verlag, New York.
20. Nosál' R., Jančinová V., Petríková M. The role of intracellular calcium in A23187-stimulated and beta-adrenoceptor blocking drug treated blood platelets. Biochem Pharmacol. 47:1994;2207-2211.
21. Haynes D.H. Effects of cyclic nucleotides and protein kinases on platelet calcium homeostasis and mobilization. Platelets. 4:1993;231-242.
22. Watson S.P., Ruggiero M., Abrahams S.L., Lapetina E.G. Inositol 1,4,5-triphosphate induced aggregation and release of 5-hydroxytryptamine from saponine-permeabilized human platelets. J Biol Chem. 261:1986;5368-5372.
23. Neumuller J., Tohidast-Akrad M., Fischer M., Mayr W.R. Influence of chloroquine or acid treatment of human platelets on the antigenicity of HLA and the thrombocyte-specific glycoproteins Ia/IIa, IIb and IIb/IIIa. Vox Sang. 65:1993;223-231.
24. 2. J Biol Chem. 264:1989;5768-5775.
25. 2 and β-thromboglobulin release in human platelets. comparative effects of thrombin and fluoroaluminate stimulation Biochim Biophys Acta. 1124:1992;279-287.
26. Mehadevapa V.G., Sicilia F. Mobilization of arachidonic acid in thrombin-stimulated human platelets. Biochim Cell Biol. 68:1990;520-527.
27. 2 activation. Arch Biochem Biophys. 289:1991;47-52.
28. Zidovetzki R., Sherman I.W., Cardenas M., Borchardt D.B. Chloroquine stabilization of phospholipid membranes against diacylglycerol-induced perturbation. Biochem Pharmacol. 45:1993;183-189.
29. 2. Biochem Pharmacol. 36:1987;1063-1067.
30. Hostetler K.Y., Matsuzawa Y. Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C. Biochem Pharmacol. 30:1981;1121-1126.
31. Shah B.H., Safdar B., Virani S.S., Nazaw Z., Saeed S.A., Gilani A.H. The antiplatelet aggregatory activity of Acacia nilotica is due to blockade of calcium influx through membrane calcium channels. Gen Pharmacol. 29:1997;251-255.
32. Dhah B.H., Nawaz Z., Virani S.S., Ali I.Q., Saeed S.A., Gilani A.H. The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. Biochem Pharmacol. 56:1998;955-960.
33. Saxena S.P., McNicol A., Brandes L.J., Becker A.B., Gerrard J.M. A role for intracellular histamine in collagen-induced platelet aggregation. Blood. 75:1990;407-414.
34. Saxena S.P., Brandes L.J., Becker A.B., Simons K.J., LaBella F.S., Gerrard J.M. Histamine is an intracellular messenger mediating platelet aggregation. Science. 243:1989;1596-1599.
35. 2+-ionophore A23187-activated human blood platelets. Platelets. 9:1998;203-206.
36. Saxena S.P., McNicol A., Brandes L.J., Becker A.B., Gerrard J.M. Histamine formed in stimulated human platelets is cytoplasmic. Biochem Biophys Res Commun. 164:1989;164-168.
37. Saxena S.P., McNicol A., Becker A.B., Brandes L.J., Thastrup O., Gerrard J.M. Biochemical and ultrastructural studies suggest that the effects of thapsigargin on human platelets are mediated by changes in intracellular calcium but not by intracellular histamine. Thromb Haemostas. 68:1992;714-718.
38. Nosál' R., Pečivová J., Drábiková K. Evidence for intracellular histamine liberation in isolated mast cells. Agents Actions. 12:1982;601-607.
39. Nosál' R., Drábiková K., Pečivová J., Jakubovský J. Histamine liberation as a result of non-receptor interaction. Agents Actions. 30:1990;74-76.
40. Nosál' R., Drábiková K., Pečivová J. Effect of chloroquine on isolated mast cells. Agents Actions. 33:1991;37-40.
41. DaPrada M., Richards J.G., Kettler R. Amine storage organelles in platelets. Gordon J.L. Platelets in Biology and Pathology 2 (Research monographs in cell and tissue physiology 5). 1981;107-145 North Holland Medical, Amsterdam.
42. Fritz M., Radmacher M., Graub H.E. Granula motion and membrane spreading during activation of human platelets imaged by atomic force microscopy. Biophys J. 66:1994;1328-1333.
43. Morgenstern E., Bastian D., Dierichs R. The formation of compound granules from different types of secretory organelles in human platelets (dense granules and α-granules). A cryofixation-substitution study using serial sections. Eur J Cell Biol. 68:1995;183-190.
44. Ferrari V., Cutler D.J. Uptake of chloroquine by human erythocytes. Biochem Pharmacol. 39:1990;753-762.
45. Nozawa Y., Nakashima S., Nagata K. Phospholipid-mediating signaling in receptor activation of human platelets. Biochim Biophys Acta. 1082:1991;219-238.