Immunomodulatory and clinical effects of Viscum album (Iscador M and Iscador P) in children with recurrent respiratory infections as a result of the chernobyl nuclear accident

American Journal of Therapeutics

Volumn 7, Issue 3, 2000, Pages 195-203

  Chernyshov, Victor P ^a   Heusser, Peter ^c   Omelchenko, Lyudmila I ^a   Chernyshova, Lyudmila I ^b   Vodyanik, Maxim A ^a   Vykhovanets, Eugene V ^a   Galazyuk, Lyudmila V ^a   Pochinok, Tatyana V ^a   Gaiday, Natalya V ^b   Gumenyuk, Marina E ^a   Zelinsky, Gennady M ^a   Schaefermeyer, Heinrich ^c   Schaefermeyer, Gabriele ^c,d  

^a STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

^b SHUPYK NATIONAL MEDICAL ACADEMY OF POSTGRADUATE EDUCATION   (Ukraine)

^c Society for Cancer Research   (Switzerland)

^d Lukas Klinik   (Switzerland)

Author keywords

Chernobyl; Immunomodulation; Radiation damage; Recurrent respiratory infections; Viscum album (Iscador)

Indexed keywords

ANTINEOPLASTIC AGENT; PLANT EXTRACT; VEGETABLE PROTEIN; VISCUM ALBUM PEPTIDE;

ADOLESCENT; ADULT; ARTICLE; CELLULAR IMMUNITY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC POWER PLANT; FEMALE; HUMAN; IMMUNE DEFICIENCY; IMMUNOLOGY; MALE; MEDICINAL PLANT; RADIATION ACCIDENT; RADIOACTIVE WASTE; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RESPIRATORY TRACT INFECTION; SUBCUTANEOUS DRUG ADMINISTRATION; UKRAINE; VISCUM ALBUM;

ACCIDENTS, RADIATION; ADOLESCENT; ADULT; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHILD; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOCOMPROMISED HOST; INJECTIONS, SUBCUTANEOUS; MALE; MISTLETOE; PLANT EXTRACTS; PLANT PROTEINS; PLANTS, MEDICINAL; POWER PLANTS; RADIOACTIVE FALLOUT; RECURRENCE; RESPIRATORY TRACT INFECTIONS; UKRAINE;

EID: 0034189813     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200007030-00007     Document Type: Article

References (25)

1. Khwaja T, Dias C, Pentecost S: Recent studies on the anticancer activities of mistletoe (Viscum album) and its alkaloids. Oncology 1986;43:42-50.
2. Hajto T: Immunomodulatory effects of Iscador: A Viscum album preparation. Oncology 1986;43:51-65.
3. Beuth J, Ko H, Tunggal L, Geisel J, Pulverer G: Vergleichende Untersuchungen zur immunaktiven Wirkung von Galaktosid-spezifischem Mistellektin. Drug Res 1993;43:166-169.
4. Gorter RW, Stein J, Stoss M, Linder M: Prospektive, longitudinale, Dosis-eskalierende, randomisierte Phase-I/ II-Studie mit Iscador® QuFrF und Iscador® Qu Spezial mit HIV-Positiven, Krebspatienten und gesunden, nichtrauchenden Probanden. Forsch Komplementärmed 1996;3:169-175.
5. Mueller E, Anderer A: Synergistic action of a plant rhamnogalacturonan enhancing antitumor cytotoxicity of human natural killer and lymphokine-activated killer cells: Chemical specificity of target cell recognition. Cancer Res 1990;50:3646-3651.
6. Hajto T, Lanzrein C: Natural killer and antibody-dependent cell-mediated cytotoxicity activities and large granular lymphocyte frequencies in Viscum album-treated breast cancer patients. Oncology 1986;43:93-97.
7. Stein GM, Berg PA: Mistletoe extract-induced effects on immunocompetent cells: In vitro studies. Anticancer Drugs 1997;8:39-42.
8. Bussing A, Azhari T, Ostendorp H, Lehnert A, Schweizer K: Viscum album L. extracts reduce sister chromatid exchanges in cultured peripheral blood mononuclear cells. Eur J Cancer 1995;30A:1836-1841.
9. Beuth J, Ko HL, Gabius HJ, Burrichter H, Oette K, Pulverer G: Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients. Clin Investig 1992;70:658-661.
10. Hajto T, Hostanska K, Gabius HJ: Zytokine als Lektin-induzierte Mediatoren in der Misteltherapie. Therapeutikon 1990;4:136-145.
11. Hajto T, Hostanska K, Frei K, Rordorf HJ, Gabius HJ: Increased secretion of tumor necrosis factor alpha, interleukin 1 and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 1990;50:3322-3326.
12. Metzner G, Franz H, Kind A, Fahlbusch B, Süss J: The in vivo activity of lectin I from mistletoe (ML-1) and its isolated A- and B-chains on functions of macrophages and polymorphonuclear cells. Immunobiology 1985;169: 461-471.
13. Jung ML, Baudino S, Ribereau-Gayon G, Beck JP: Characterization of cytotoxic proteins from mistletoe (Viscum album L.). Cancer Lett 1990;51:103-108.
14. Chernyshov VP, Vykhovanets EV, Slukvin II, Antipkin YG, Vasyuk AN, Strauss KW: Analysis of blood lymphocyte subsets in children living on territory that received high amounts of fallout from Chernobyl accident. Clin Immunol Immunopathol 1997;84:122-128.
15. Lukyanova EM, Chernyshov VP, Omelchenko LI, et al: Behandlung immunsupprimierter Kinder nach dem Tschernobyl-Unfall mit Viscum album (Iscador): Klinische und immunologische Untersuchungen. Forsch Komplementärmed 1994;158-70.
16. Chernyshov VP, Omelchenko LI, Heusser P, et al: Immunomodulatory actions of Viscum album (Iscador) in children with recurrent respiratory disease as a result of the Chernobyl nuclear accident. Complementary Ther Med 1997;5:141-146.
17. Erkeller-Yuksel FM, Deneys V, Yuksel B, et al: Age-related changes in human blood lymphocyte subpopulations. J Pediatr 1992;120:216-222.
18. Reichert T, DeBruyere M, Deneys V, et al: Lymphocyte subsets reference ranges in adult Caucasians. Clin Immunol Immunopathol 1991;60:190-208.
19. Blomberg K, Granberg C, Hemmila I, Lovgren T: Europium-labeled target cells in an assay of natural killer cell activity. I. A novel non-radioactive method based on time-resolved fluorescence. J Immunol Methods 1986;86: 225-229.
20. Patterson-Delfield J, Lehrer PI: A simple microscopic method for identifying and quantitating phagocytic cells in vitro. J Immunol Methods 1977;18:377-379.
21. Baehner R, Nathan DG: Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med 1968;274:971-976.
22. Wadhwa M, Bird C, Tinker A, Mure-Sluis A, Torpe R: Quantitative biological assays for individual cytokines. In: Cytokines: A Practical approach. (Ed. Balcwill FR), IRL Press, Oxford, 1991, pp 309-330.
23. Rosen FS, Wedgwood RJ, Eibl M, et al: Primary immunodeficiency diseases. Report of a WHO Scientific Group. Clin Exp Immunol 1995;99:1-24.
24. Langford MP, Yin-Murphy M, Ho YM, Barber JC, Baron S, Stanton GJ: Human fibroblast interferon in tears of patients with picornavirus epidemic conjunctivitis. Infect Immunol 1980;29:995-998.
25. Grundy JE, Trapman J, Allan JE, Shellum AR, Mullef CJ: Evidence for a protective role of interferon in resistance to murine cytomegaloviruses and its control by non-H2-linked genes. Infect Immunol 1982;34:43-50.