The effects of mutated skeletal ryanodine receptors on hypothalamic-pituitary-adrenal axis function in boars

Journal of Animal Science

Volumn 78, Issue 5, 2000, Pages 1319-1330

  Weaver, S A ^a,b   Dixon, W T ^a   Schaefer, A L ^a  

^a LACOMBE RESEARCH CENTRE   (Canada)

^b PURDUE UNIVERSITY   (United States)

Author keywords

ACTH; Brain; Cortisol; Glucocorticoid Receptor; Pig; Ryanodine Receptor

Indexed keywords

SUIDAE; SUS SCROFA;

CORTICOTROPIN; HYDROCORTISONE; RYANODINE RECEPTOR;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BONE; GENETICS; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; MEAT; METABOLISM; MUTATION; PHYSIOLOGY; RADIOIMMUNOASSAY; STANDARD; SWINE; WESTERN BLOTTING;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOTTING, WESTERN; BONE AND BONES; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MEAT; MUTATION; PITUITARY-ADRENAL SYSTEM; RADIOIMMUNOASSAY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SWINE;

EID: 0034186513     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2000.7851319x     Document Type: Article

References (45)

1. Aalhus, J. L., B. R. Best, F. Costello, and A. L. Schaefer. 1997. The effects of porcine somatotropin on muscle fiber morphology and meat quality of pigs of known stress susceptibility. Meat Sci. 45:283-295.
2. Adeola, O., R. O. Ball, J. D. House, and P. J. O'Brien. 1993. Regional brain neurotransmitter concentrations in stress-susceptible pigs. J. Anim. Sci. 71:968-974.
3. Agriculture Canada. 1984. Pork Quality: A Guide to Understanding Color and Structure of Pork Muscle. Publ. 5180/B. Agriculture Canada, Ottawa, ON.
4. Akana, S. F., C. S. Cascio, J. Shinsako, and M. F. Dallman. 1985. Corticosterone: Narrow range required for normal body and thymus weight and ACTH. Am. J. Physiol. 249:R527-R532.
5. Barnett, J., C. Winfield, G. Cronin, and A. Makin. 1981. Effects of photoperiod and feeding on plasma corticosteroid concentrations and maximum corticosteroid-binding capacity in pigs. Aust. J. Biol. Sci. 34:577-585.
6. Bradbury, M. J., S. F. Akana, and M. F. Dallman. 1994. Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: Evidence for a nonadditive effect of combined receptor occupation. Endocrinology 134:1286-1296.
7. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
8. Canadian Council on Animal Care. 1993. A Guide to the Care and use of Experimental Animals (Vol. 1, 2nd Ed.). Canadian Council on Animal Care, Ottawa, ON.
9. Cook, N. J., A. L. Schaefer, P. Lepage, and S. Morgan Jones. 1996. Salivary vs. serum cortisol for the assessment of adrenal activity in swine. Can. J. Anim. Sci. 76:329-335.
10. D'Allaire, S., and L. DeRoth. 1986. Physiological responses to treadmill exercise and ambient temperature in normal and malignant hyperthermia susceptible pigs. Can. J. Vet. Res. 50:78-83.
11. Devenport, L., A. Knehans, A. Sundstrom, and T. Thomas. 1989. Corticosterone's dual metabolic actions. Life Sci. 45:1389-1396.
12. Diorio, D., V. Viau, and M. J. Meaney. 1993. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J. Neurosci. 9:3839-3847.
13. Dugan, M. E. R., A. K. W. Tong, J. P. Carlson, B. R. Schricker, J. L. Aalhus, A. L. Schaefer, A. P. Sather, A. C. Murray, and S. D. M. Jones. 1997. The effects of porcine somatotropin, gender, and porcine stress syndrome on growth carcass composition and pork quality. Can. J. Anim. Sci. 77:233-240.
14. Ekkel, E. D., C. E. A. van Doorn, M. J. C. Hessing, and M. J. M. Tielen. 1995. The specific-stress-free housing system has positive effects on productivity, health, and welfare of pigs. J. Anim. Sci. 73:1544-1551.
15. 2+ release. J. Biol. Chem. 272:20967-20970.
16. Fujii, J., K. Otsu, F. Zorzato, S. De Leon, V. Khanna, J. Weiler, P. J. O'Brien, and D. H. MacLennan. 1991. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science (Wash DC) 253:448-451.
17. Geers, R., E. Bleus, T. Van Schie, H. Ville, H. Gerard, S. Hanssens, G. Nackaerts, E. Decuypere, and J. Jourquin. 1994. Transport of pigs different with respect to the halothane gene: Stress assessment. J. Anim. Sci. 72:2552-2558.
18. Hemsworth, P. H., J. L. Barnett, and R. G. Campbell. 1996. A study of the relative aversiveness of a new daily injection procedure for pigs. Appl. Anim. Behav. Sci. 49:389-401.
19. Hemsworth, P. H., J. L. Barnett, and C. Hansen. 1986. The influence of handling by humans on the behaviour, reproduction and corticosteroids of male and female pigs. Appl. Anim. Behav. Sci. 15:303-314.
20. Hyun, Y., M. Ellis, G. Riskowski, and R. W. Johnson. 1998. Growth performance of pigs subjected to multiple concurrent environmental stressors. J. Anim. Sci. 76:721-727.
21. Janssens, C., F. A. Helmond, and V. M. Wiegant. 1995. Chronic stress and pituitary-adrenocortical responses to corticotropin-releasing hormone and vasopressin in female pigs. Eur. J. Endocrinol. 132:479-486.
22. Keller-Wood, M., and M. Dallman. 1984. Corticosteroid inhibition of ACTH secretion. Endocr. Rev. 5:1-24.
23. Levis, D. G., J. L. Barnett, P. H. Hemsworth, and E. Jongman. 1995. The effect of breeding facility and sexual stimulation on plasma cortisol in boars. J. Anim. Sci. 73:3705-3711.
24. 2+ release from internal stores: Role in generating depolarizing after-potentials in rat supraoptic neurones. J. Physiol. (Lond.) 498.2:339-350.
25. Lister, D. 1987. The physiology and biochemistry of the porcine stress syndrome. In: P. V. Tarrant, G. Eikelenboom, and G. Monin (Ed.) Evaluation and Control of Meat Quality in Pigs. pp 3-16. Martinus Nijhoff Publishers, Boston, MA.
26. MacLennan, D.H., and M. S. Philips. 1992. Malignant hyperthermia. Science (Wash DC) 256:789-794.
27. Martin, E. E., M. H. Cake, P. E. Hartmann, and I. F. Cook. 1977. Relationship between foetal corticosteroids, maternal progesterone, and parturition in the rat. Acta Endocrinol. 84:167-176.
28. Murray, A. C., C. P. Johnson, and L. M. Murdoch. 1993. Comparison of blood marker and DNA analyses for detection of the halothane genotype of pigs. Meat Sci. Technol. 39:S4P18.
29. Nyberg, L., K. Lundstrom, I. Edfors-Lilja, and M. Rundren. 1988. Effects of transport stress on concentrations of cortisol, corticosteroid-binding globulin and glucocorticoid receptors in pigs with different halothane genotypes. J. Anim. Sci. 66:1201-1211.
30. O'Brien, P. J., H. Shen, C. R. Corey, and X. Zhang. 1993. Use of a DNA-based test for the mutation associated with porcine stress syndrome (malignant hyperthermia) in 10,000 breeding swine. J. Am. Vet. Med. Assoc. 203:842-851.
31. Otsu, K., M. S. Phillips, V. K. Khanna, S. De Leon, and D. H. MacLennan. 1992. Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia. Genomics 13:201-214.
32. Reul, M., and E. de Kloet. 1985. Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation. Endocrinology 117:2505-2511.
33. Roberts, S. A., L. Thibault, A. C. Murray, and A. L. Schaefer. 1996. The effect of dietary protein source on biochemical indices of stress in stress-susceptible pigs. Can. J. Anim. Sci. 76:401-408.
34. Rots, N. Y., J. de Jong, J. O. Workel, S. Levine, A. R. Cools, and E. R. De Kloet. 1996. Neonatal maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine. J. Neuroendocrinol. 8:501-506.
35. Ruis, M. A. W., J. H. A. Te Brake, B. Engel, E. D. Ekkel, W. G. Buist, H. J. Blokhuis, and J. M. Koolhaas. 1997. The circadian rhythm of salivary cortisol in growing pigs: effects of age, gender, and stress. Physiol. Behav. 62:623-630.
36. Sapolsky, R. M., M. J. Meaney, and B. S. McEwen. 1985. The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation. Dev. Brain Res. 18:169-173.
37. Sather, A. P., and A. C. Murray. 1989. The development of a halothane sensitive line of pigs. Can. J. Anim. Sci. 9:323-331.
38. Schaefer, A. L., H. Doornenbal, A. P. Sather, A. K. Tong, S. D. Jones, and A. C. Murray. 1990. The use of blood serum components in the identification of stress-susceptible and carrier pigs. Can. J. Anim. Sci. 70:845-855.
39. Schaefer, A. L., H. Doornenbal, A. K. W. Tong, A. C. Murray, and A. P. Sather. 1987. Effect of time off feed on blood acid-base homeostasis in pigs differing in their reaction to halothane. Can. J. Anim. Sci. 67:427-436.
40. Sebranek, J. G., D. N. Marple, R. G. Cassens, E. J. Briskey, and L. L. Kastenschmidt. 1973. Adrenal response to ACTH in the pig. J. Anim. Sci. 36:41-44.
41. Segal, M. 1989. Serotonin modulation of hippocampal activity. In: C. V. Palay and C. Kohler (Ed.) The Hippocampus: New Vistas, pp 307-315. Alan R. Liss, New York.
42. Sutanto, W., P. Rosenfeld, E. R. de Kloet, and S. Levine. 1996. Long-term effects of neonatal maternal deprivation and ACTH on hippocampal mineralocorticoid did and glucocorticoid receptors. Dev. Brain Res. 92:156-163.
43. van Eekelen, J., W. Jiang, E. de Kloet, and M. Bohn. 1988. Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus. J. Neurosci. Res. 21:88-94.
44. Walker C D., M. Perrin, W. W. Vale, and C. Rivier. 1986. Ontogeny of the stress response in the rat: Role of the pituitary and hypothalamus. Endocrinology 127:1445-1451.
45. Weaver, S. A., A. L. Schaefer, and W. T. Dixon. 2000. The effects of mutated skeletal ryanodine receptors on calreticulin and calsequestrin expression in the brain and pituitary gland of boars. Mol. Brain Res. 75:46-53.