Evaluation of intratesticular injection of glycerol for nonsurgical sterilization of dogs

American Journal of Veterinary Research

Volumn 61, Issue 5, 2000, Pages 544-549

  Immegart, Heidi M ^a,b   Threlfall, Walter R ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Vet Reproductive Specialists LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

GLYCEROL; TESTOSTERONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOPSY; BLOOD; CONTRACEPTION; DOG; DRUG EFFECT; ECHOGRAPHY; INJECTION; MALE; METHODOLOGY; ORCHIECTOMY; PHYSIOLOGY; RADIOIMMUNOASSAY; SPERM; SPERMATOZOON COUNT; TESTIS;

ANIMALS; BIOPSY; DOGS; GLYCEROL; INJECTIONS; MALE; ORCHIECTOMY; RADIOIMMUNOASSAY; SEMEN; SPERM COUNT; STERILIZATION, REPRODUCTIVE; TESTIS; TESTOSTERONE;

EID: 0034186160     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2000.61.544     Document Type: Article

References (43)

1. Matsumoto AM. Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production. J Clin Endocr Metab 1990;70:282-287.
2. Matsumoto AM. Is high dosage testosterone an effective male contraceptive agent? Fertil Steril 1988;50:324-328.
3. Rajalakshmi M, Ramakroshnan PR. Pharmacokinetics and pharmacodynamics of a new long-acting androgen ester: maintenance of physiological androgen levels for 4 months after a single injection. Contraception 1989;40:399-412.
4. Weinbauer GF, Marshall GR, Nieschlag E. New injectable testosterone ester maintains serum testosterone in castrated monkeys in the normal range for four months. Acta Endocrinol (Copenh) 1986;113:128-132.
5. World Health Organization Task Force of Methods for the Regulation of Male Fertility. Contraceptive efficacy of testosterone-induced azoospermia in normal men. Lancet 1990;336:955-959.
6. Olsen PN, Bett TM, Bowen RA, et al. Potential methods of contraception for dogs and cats. Compend Contin Educ Pract Vet 1989;10:132-138.
7. Pryor JP. The role of steroids as male contraceptives. In: Jeffcoate SL, Sandler M, eds. Progress towards a male contraceptive. New York: John Wiley & Sons, 1982;135-144.
8. Swerdloff RS, Wang C, Bhasin S. Developments in the control of testicular function. Bailliere's Clin Endocrinol and Metab 1992;6:451-483.
9. Paulson CA. Androgen-progestogen combinations. In: Zatuchni GI, Goldsmith A, Spieler JM, et al, eds. Male contraception: advances and future prospects. Philadelphia: Harper & Row, 1986;300-303.
10. Wu FCW, Aitken RJ. Suppression of sperm function by depot medroxyprogesterone acetate and testosterone enanthate in steroid male contraception. Fertil Steril 1989;51:691-698.
11. Wu FCW. Male contraception: current status and future prospects. Clinical Endocr 1988;29:443-465.
12. Dhar JD, Setty BS. Effect of a nonsteroidal antiandrogen, anandron, on the reproductive system and fertility in male rats. Contraception 1990;42:121-138.
13. Neumann F, Schenck B. Antiandrogens: basic concepts and clinical trials. In: Cunningham GR, Schill WB, Hafez ESE, eds. Regulation of male fertility. The Netherlands: Martinus Nijhoff, 1980;93-104.
14. Wang C, Yeung KK. Use of low-dosage oral cyproterone acetate as a male contraceptive. Contraception, 1980;21:245-272.
15. Cavitte C, Lahlou N, Mialot JP, et al. Reversible effects of long-term treatment with D-Trp6-LH-RH-microcapsules on pituitary-gonadal axis, spermatogenesis and prostate morphology in adolescent and adult Dogs. Andrologia 1988;20:249-263.
16. Dube D, Assaf A, Pelletier G, et al. Morphological study of the effects of an GnRH agonist on the canine testis after 4 months of treatment and recovery. Acta Endocrinol (Copenh) 1987;116:413-417.
17. Trembley Y, Belanger A, Lacoste D, et al. Selective inhibition of spermatogenesis in the presence of normal libido following combined treatment with an LHRH agonist and testosterone in the dog. Contraception 1984;30:585-598.
18. Tremblay Y, Belanger A. Reversible inhibition of gonadal functions by a potent gonadotropin-releasing hormone agonist in adult dog. Contraception, 1984;30:483-497.
19. Dowsett KF, Pattie WA, Knott LM, et al. A preliminary study of immunological castration in colts. J Reprod Fert Suppl 1991;44:183-190.
20. Gonzalez A, Allen AF, Post AK, et al. Immunological approaches to contraception in dogs. J Reprod Fert Suppl 1989;39:189-198.
21. Guha SK, Ansari S, Anand S, et al. Contraception in male monkeys by intra-vas deferens injection of a pH lowering polymer. Contraception 1985;32:109-118.
22. Guha SK, Singh G, Anand S, et al. Phase 1 clinical trial of an injectable contraceptive for the male. Contraception 1993;48: 367-375.
23. Huber DH, Hong S, Ross JA. The international experience with vasectomy. In: Zatuchni GI, Goldsmith A, Spieler JM, et al, eds. Male contraception: advances and future prospects. Philadelphia: Harper & Row, 1986;7-18.
24. Liu X, Li S. Vasal sterilization in China. Contraception 1993;48:255-263.
25. Pineda MH, Dooley MP. Surgical and chemical vasectomy in the cat. Am J Vet Res 1984;45:291-300.
26. Riar SS, Thomas P, Kain AK, et al. Ionized copper as contraceptive in male rhesus monkey. Andrologia 1984;16:116-117.
27. Sethi N, Srivastava RK, Singh RK. Male mediated teratogenic potential evaluation of new antifertility compound SMA in rabbit (Oryctolagus cuniculus). Contraception 1990;42:215-223.
28. Fahim MS, Wang M, Sutcu MF, et al. Sterilization of dogs with intra-epididymal injection of zinc arginine. Contraception 1993;47:107-122.
29. Heath E, Arowolo R. The early histopathologic effects of intratesticular injection with hyperosmolar glycerol, glucose or NaCl solutions. Andrologia 1987;19:654-661.
30. Weinbauer GF, Drobnitzky F, Galhotra MM, et al. Intratesticular injection of glycerol as a model for studying the quantitative relationship between spermatogenic damage and serum FSH. J Endocrinol 1987;115:83-90.
31. Wiebe JP, Barr KJ, Buckingham KD. Sustained azoospermia in the squirrel monkey, Saimiri sciureus, resulting from a single intratesticular glycerol injection. Contraception 1989;39:447-457.
32. Wiebe JP, Barr KJ. The control of male fertility by 1,2,3-trihydroxypropane (THP; glycerol): rapid arrest of spermatogenesis without altering libido, accessory organs, gonadal steroidogenesis, and serum testosterone, LH and FSH. Contraception, 1984;29:291-302.
33. Wiebe JP, Barr KJ, Buckingham KD, et al. Prospects of a male contraceptive based on the selective antispermatogenic action of 1,2,3-trihydroxypropane (THP, glycerol). In: Zatuchni GI, Goldsmith A, Spieler JM, et al, eds. Male contraception: advances and future prospects. Philadelphia: Harper & Row, 1986;252-270.
34. England GCW. Relationship between ultrasonographic appearance, testicular size, spermatozoal output and testicular lesions in the dog. J Small Anim Pract 1991;32:306-311.
35. Daniel WW. Biostatistics: a foundation for analysis in the health sciences. 5th ed. New York: John Wiley & Sons, 1987;218-221.
36. Terada T, Hatakeyama S. Morphological evidence for two types of idiopathic "sertoli-cell-only" syndrome. Int J Androl 1991;14:117-126.
37. Concannon PW. Reproduction in the dog and cat. In: Cupps PT. ed. Reproduction in domestic animals. 4th ed. San Diego: Academic Press Inc. 1991;517-554.
38. Lopate C, Threlfall WR, Rosol TJ. Histopathologic and gross effects of testicular biopsy in the dog. Theriogenology 1989;32:585-602.
39. Feldman EC, Nelson RW. Canine and feline endocrinology and reproduction. Philadelphia: WB Saunders Co, 1987;481-493.
40. Coffey DS. Androgen action and the sex accessory tissues. In: Knobil E, Neill JD, eds. The physiology of reproduction. Volume 1. New York: Raven Press, 1988;1081-1119.
41. Jones TC, Hunt RD. Veterinary pathology. 5th ed. Philadelphia: Lea & Febiger, 1983;1-103.
42. Christensen GC. The urogenital apparatus. In: Evans HE, Christensen GC. Miller's anatomy of the dog. Philadelphia: WB Saunders Co, 1979;544-601
43. Davis JR, Langford GA, Kirby PJ. The testicular capsule. In: Johnson AD, Gomes WR, Vandemark, eds. The testis. New York: Academic Press Inc, 1970;285-293.