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Volumn 150, Issue 1, 2000, Pages 113-120

HDL steady state levels are not affected, but HDL apoA-I turnover is enhanced by Lifibrol in patients with hypercholesterolemia and mixed hyperlipidemia

Author keywords

Apolipoprotein A I; Cholesterol lowering drugs; In vivo kinetics; Stable isotopes

Indexed keywords

ANTILIPEMIC AGENT; APOLIPOPROTEIN A1; BUTANOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYBENZOIC ACID DERIVATIVE; LIFIBROL;

EID: 0034185611     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00351-2     Document Type: Article
Times cited : (13)

References (45)
  • 1
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S), Lancet 1994;344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 2
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. West of Scotland Coronary Prevention Study Group
    • Sheperd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ. Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. West of Scotland Coronary Prevention Study Group. New Engl J Med 1995;333:1301-7.
    • (1995) New Engl J Med , vol.333 , pp. 1301-1307
    • Sheperd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    MacFarlane, P.W.6    McKillop, J.H.7    Packard, C.J.8
  • 4
    • 0016433018 scopus 로고
    • Plasma-high density-lipoprotein concentration and development of ischemic heart-disease
    • Miller GJ, Miller NE. Plasma-high density-lipoprotein concentration and development of ischemic heart-disease. Lancet 1975;1:16-9.
    • (1975) Lancet , vol.1 , pp. 16-19
    • Miller, G.J.1    Miller, N.E.2
  • 5
    • 0024449985 scopus 로고
    • High-density lipoprotein -the clinical implications of recent studies
    • Gordon DJ, Rifkind BM. High-density lipoprotein -the clinical implications of recent studies. New Engl J Med 1989;321:1311-6.
    • (1989) New Engl J Med , vol.321 , pp. 1311-1316
    • Gordon, D.J.1    Rifkind, B.M.2
  • 6
    • 0026091744 scopus 로고
    • A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction
    • Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. New Engl J Med 1991;325:373-81.
    • (1991) New Engl J Med , vol.325 , pp. 373-381
    • Stampfer, M.J.1    Sacks, F.M.2    Salvini, S.3    Willett, W.C.4    Hennekens, C.H.5
  • 7
    • 0026734174 scopus 로고
    • A prospective study of obesity, lipids, apolipoproteins and ischemic heart disease in women
    • Coleman MP, Key TJA, Wang DY. A prospective study of obesity, lipids, apolipoproteins and ischemic heart disease in women. Atherosclerosis 1992;92:177-85.
    • (1992) Atherosclerosis , vol.92 , pp. 177-185
    • Coleman, M.P.1    Key, T.J.A.2    Wang, D.Y.3
  • 9
    • 0024582211 scopus 로고
    • Hypolipidemic activity of K12.148 in rats, marmosets and pigs
    • Schliack M, Löser R, Seibel K, Blay KH. Hypolipidemic activity of K12.148 in rats, marmosets and pigs. Artery 1989;16:90-104.
    • (1989) Artery , vol.16 , pp. 90-104
    • Schliack, M.1    Löser, R.2    Seibel, K.3    Blay, K.H.4
  • 10
    • 0028890173 scopus 로고
    • Lifibrol: A novel lipid-lowering drug for the therapy of hypercholesterolaemia
    • Locker PK, Jungbluth GL, Francom SF, Hughes GS, for the Lifibrol study group. Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolaemia, Clin. Pharmacol. Ther. 1995;57:73-88.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 73-88
    • Locker, P.K.1    Jungbluth, G.L.2    Francom, S.F.3    Hughes, G.S.4
  • 11
    • 0030911343 scopus 로고    scopus 로고
    • Lifibrol: First member of a new class of lipid-lowering drugs?
    • Scharnagl H, März W, Wieland H. Lifibrol: first member of a new class of lipid-lowering drugs? Exp Opin Invest Drugs 1997;6:583-91.
    • (1997) Exp Opin Invest Drugs , vol.6 , pp. 583-591
    • Scharnagl, H.1    März, W.2    Wieland, H.3
  • 15
    • 33745026603 scopus 로고
    • The distribution and chemical composition of ultracentrifugally separated lipoproteins in human plasma
    • Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human plasma. J Clin Invest 1955;34:1345-53.
    • (1955) J Clin Invest , vol.34 , pp. 1345-1353
    • Havel, R.J.1    Eder, H.A.2    Bragdon, J.H.3
  • 16
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1979;227:680-5.
    • (1979) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 17
    • 0026769254 scopus 로고
    • Tracer to tracee ratio for analysis of stable isotope tracer data: Link with radiotracer formalism
    • Cobelli CC, Toffolo G, Foster DM. Tracer to tracee ratio for analysis of stable isotope tracer data: link with radiotracer formalism. Am J Physiol 1992;262:E968-75.
    • (1992) Am J Physiol , vol.262
    • Cobelli, C.C.1    Toffolo, G.2    Foster, D.M.3
  • 18
    • 0026661513 scopus 로고
    • Investigation of lipoprotein kinetics using endogenous labeling with stable isotopes
    • Schaefer JR, Rader DJ, Brewer Jr HB. Investigation of lipoprotein kinetics using endogenous labeling with stable isotopes. Curr Opin Lipidol 1993;3:227-32.
    • (1993) Curr Opin Lipidol , vol.3 , pp. 227-232
    • Schaefer, J.R.1    Rader, D.J.2    Brewer Jr., H.B.3
  • 19
    • 0023511517 scopus 로고
    • Models to interpret kinetic data in stable isotope tracer studies
    • Cobelli C, Toffolo G, Bier DM, Nosadini R. Models to interpret kinetic data in stable isotope tracer studies. Am J Physiol 1987;253:E551-64.
    • (1987) Am J Physiol , vol.253
    • Cobelli, C.1    Toffolo, G.2    Bier, D.M.3    Nosadini, R.4
  • 20
    • 0027135335 scopus 로고
    • Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods
    • Ikewaki K, Rader DJ, Schaefer JR, Fairwell T, Zech LA, Brewer Jr. HB Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods. J Lipid Res 1993;34:2207-15.
    • (1993) J Lipid Res , vol.34 , pp. 2207-2215
    • Ikewaki, K.1    Rader, D.J.2    Schaefer, J.R.3    Fairwell, T.4    Zech, L.A.5    Brewer Jr., H.B.6
  • 21
    • 0025264443 scopus 로고
    • Measurement of very low density and low density lipoprotein apolipoprotein (apo) B-100 and high density lipoprotein apoA-I production in human subjects using deuterated leucine. Effect of fasting and feeding
    • Cohn JS, Wagner DA, Cohn SD, Millar JS, Schaefer EJ. Measurement of very low density and low density lipoprotein apolipoprotein (apo) B-100 and high density lipoprotein apoA-I production in human subjects using deuterated leucine. Effect of fasting and feeding. J Clin Invest 1990;85:804-11.
    • (1990) J Clin Invest , vol.85 , pp. 804-811
    • Cohn, J.S.1    Wagner, D.A.2    Cohn, S.D.3    Millar, J.S.4    Schaefer, E.J.5
  • 22
    • 0028033973 scopus 로고
    • Effects of postmenopausal hormone replacement with oral and transdermal estrogen on high density lipoprotein metabolism
    • Walsh BW, Li H, Sacks FM. Effects of postmenopausal hormone replacement with oral and transdermal estrogen on high density lipoprotein metabolism. J Lipid Res 1994;35:2083-93.
    • (1994) J Lipid Res , vol.35 , pp. 2083-2093
    • Walsh, B.W.1    Li, H.2    Sacks, F.M.3
  • 24
    • 0026032547 scopus 로고
    • Clinical pharmacology of the hypocholesterolemic agent K12.148 (Lifibrol) in healthy volunteers
    • Hasibeder H, Staab HJ, Seibel K, Schmidle G, März W. Clinical pharmacology of the hypocholesterolemic agent K12.148 (Lifibrol) in healthy volunteers. Eur J Clin Pharmacol 1991;40(Suppl.1):S91-4.
    • (1991) Eur J Clin Pharmacol , vol.40 , Issue.1 SUPPL.
    • Hasibeder, H.1    Staab, H.J.2    Seibel, K.3    Schmidle, G.4    März, W.5
  • 25
    • 0001949457 scopus 로고
    • Lovastatin increases apolipoprotein A-I levels in subjects with isolated reductions in high density lipoproteins
    • Ginsberg HN, Ngai C, Ramakrishnan R. Lovastatin increases apolipoprotein A-I levels in subjects with isolated reductions in high density lipoproteins. Circulation: II 1991;84:140.
    • (1991) Circulation: II , vol.84 , pp. 140
    • Ginsberg, H.N.1    Ngai, C.2    Ramakrishnan, R.3
  • 26
    • 0033049802 scopus 로고    scopus 로고
    • Metabolic basis of high density lipoproteins and apolipoprotein A-I increase by HMG-CoA reductase inhibition in healthy subjects and a patient with coronary artery disease
    • Schaefer JR, Schweer H, Ikewaki K, Stracke H, Seyberth HJ, Kaffarnik H, Maisch B, Steinmetz A. Metabolic basis of high density lipoproteins and apolipoprotein A-I increase by HMG-CoA reductase inhibition in healthy subjects and a patient with coronary artery disease. Atherosclerosis 1999;144:177-84.
    • (1999) Atherosclerosis , vol.144 , pp. 177-184
    • Schaefer, J.R.1    Schweer, H.2    Ikewaki, K.3    Stracke, H.4    Seyberth, H.J.5    Kaffarnik, H.6    Maisch, B.7    Steinmetz, A.8
  • 28
    • 0024400377 scopus 로고
    • Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women
    • Brinton EA, Eisenberg S, Breslow JL. Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women. J Clin Invest 1989;84:262-9.
    • (1989) J Clin Invest , vol.84 , pp. 262-269
    • Brinton, E.A.1    Eisenberg, S.2    Breslow, J.L.3
  • 29
    • 0026784634 scopus 로고
    • Physicologic mechanisms for reduced apolipoprotein A-I concentrations associated with low levels of high density lipoprotein cholesterol in patients with normal plasma lipids
    • Gylling H, Vega GL, Grundy SM. Physicologic mechanisms for reduced apolipoprotein A-I concentrations associated with low levels of high density lipoprotein cholesterol in patients with normal plasma lipids. J Lipid Res 1992;33:1527-39.
    • (1992) J Lipid Res , vol.33 , pp. 1527-1539
    • Gylling, H.1    Vega, G.L.2    Grundy, S.M.3
  • 30
    • 0021824527 scopus 로고
    • Mechanism of action of Gemfibrozil on lipoprotein metabolism
    • Saku K, Gartside PS, Hynd BA, Kashyap ML. Mechanism of action of Gemfibrozil on lipoprotein metabolism. J Clin Invest 1985;75:1702-12.
    • (1985) J Clin Invest , vol.75 , pp. 1702-1712
    • Saku, K.1    Gartside, P.S.2    Hynd, B.A.3    Kashyap, M.L.4
  • 31
    • 0029793860 scopus 로고    scopus 로고
    • Gemfibrozil stimulates apolipoprotein A-I synthesis and secretion by stabilization of mRNA transcripts in human hepatoblastoma cell line (HepG2)
    • Jin F-Y, Kamanna VS, Mei-Yu C, Kengathevy M, Kashyap ML. Gemfibrozil stimulates apolipoprotein A-I synthesis and secretion by stabilization of mRNA transcripts in human hepatoblastoma cell line (HepG2). Arterioscler Thromb Vase Biol 1996;16:1052-62.
    • (1996) Arterioscler Thromb Vase Biol , vol.16 , pp. 1052-1062
    • Jin, F.-Y.1    Kamanna, V.S.2    Mei-Yu, C.3    Kengathevy, M.4    Kashyap, M.L.5
  • 32
    • 0026330602 scopus 로고
    • HDL metabolism in HDL deficiency associated with familial hypertriglyceridemia: Effect of treatment with Gemfibrozil
    • Kashyap ML, Saku K. HDL metabolism in HDL deficiency associated with familial hypertriglyceridemia: effect of treatment with Gemfibrozil. Adv Exp Med Biol 1991;285:233-6.
    • (1991) Adv Exp Med Biol , vol.285 , pp. 233-236
    • Kashyap, M.L.1    Saku, K.2
  • 33
    • 0021868786 scopus 로고
    • Effects of Fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia
    • Malmendier CL, Delcroix C. Effects of Fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia. Atherosclerosis 1985;5:161-9.
    • (1985) Atherosclerosis , vol.5 , pp. 161-169
    • Malmendier, C.L.1    Delcroix, C.2
  • 34
    • 0014264541 scopus 로고
    • The plasma lecithin: Cholesterol acyltransferase reaction
    • Glomset JA. The plasma lecithin: cholesterol acyltransferase reaction. J Lipid Res 1968;9:155-67.
    • (1968) J Lipid Res , vol.9 , pp. 155-167
    • Glomset, J.A.1
  • 35
    • 0028887870 scopus 로고
    • Molecular physiology of reverse cholesterol transport
    • Fielding CJ, Fielding PE. Molecular physiology of reverse cholesterol transport. J Lipid Res 1995;36:211-28.
    • (1995) J Lipid Res , vol.36 , pp. 211-228
    • Fielding, C.J.1    Fielding, P.E.2
  • 37
    • 0028069487 scopus 로고
    • In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport
    • Pieters MN, Scheuten D, VanBerkel TJC. In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport. Biochim Biophys Acta 1994;1225:125-34.
    • (1994) Biochim Biophys Acta , vol.1225 , pp. 125-134
    • Pieters, M.N.1    Scheuten, D.2    VanBerkel, T.J.C.3
  • 38
    • 0030017590 scopus 로고    scopus 로고
    • Unraveling high density lipoprotein-apolipoprotein metabolism in human mutants and animal models
    • Rader DJ, Ikewaki K. Unraveling high density lipoprotein-apolipoprotein metabolism in human mutants and animal models. Curr Opin Lipidol 1996;7:117-23.
    • (1996) Curr Opin Lipidol , vol.7 , pp. 117-123
    • Rader, D.J.1    Ikewaki, K.2
  • 39
    • 0029820675 scopus 로고    scopus 로고
    • Apolipoprotein function in health and disease. Insights from natural mutations
    • Franceschini G. Apolipoprotein function in health and disease. Insights from natural mutations. Eur J Clin Invest 1996;26:733-46.
    • (1996) Eur J Clin Invest , vol.26 , pp. 733-746
    • Franceschini, G.1
  • 40
    • 0029783094 scopus 로고    scopus 로고
    • Effects of deletion of the carboxy-terminal domain of ApoA-I or of its substitution with helices of ApoA-II on in vitro and in vivo lipoprotein association
    • Holvoet P, Zhao Z, Deridder E, Dhoest A, Collen D. Effects of deletion of the carboxy-terminal domain of ApoA-I or of its substitution with helices of ApoA-II on in vitro and in vivo lipoprotein association. J Biol Chem 1996;271:19395-401.
    • (1996) J Biol Chem , vol.271 , pp. 19395-19401
    • Holvoet, P.1    Zhao, Z.2    Deridder, E.3    Dhoest, A.4    Collen, D.5
  • 41
    • 0030878533 scopus 로고    scopus 로고
    • High density lipoprotein and coronary heart disease: Insights from mutations leading to low high density lipoprotein
    • Calabresi C, Franceschini G. High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein. Curr Opin Lipidol 1997;8:219-24.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 219-224
    • Calabresi, C.1    Franceschini, G.2
  • 44
    • 10644262027 scopus 로고
    • In vitro apo B-100 and apo A-I kinetics in Tangier disease utilizing a stable isotope technique
    • Schaefer JR, Rader DJ, Gregg RE. In vitro apo B-100 and apo A-I kinetics in Tangier disease utilizing a stable isotope technique. Circulation 1990;82(III):447.
    • (1990) Circulation , vol.82 , Issue.3 , pp. 447
    • Schaefer, J.R.1    Rader, D.J.2    Gregg, R.E.3


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