Prednisolone modulates the therapeutic effect of interferon to eliminate preferentially the hepatitis B virus precore stop mutant

Journal of Hepatology

Volumn 32, Issue 5, 2000, Pages 829-836

  Yeh, Chau Ting ^a   Sheen, I Shyan ^a   Chen, Tse Ching ^b   Hsieh, Sen Yung ^a   Chu, Chia Ming ^a   Liaw, Yun Fan ^a,c  

^a Liver Research Unit   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c Yun Fan Liaw   (Taiwan)

Author keywords

Hepatitis B virus; Interferon; Precore mutant; Prednisolone

Indexed keywords

ALPHAN1 INTERFERON; HEPATITIS B(E) ANTIGEN; INTERFERON; PREDNISOLONE; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; CORE PROTEIN;

ADULT; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOMODULATION; MUTANT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; DRUG INTERACTION; GENETICS; MUTATION; ORAL DRUG ADMINISTRATION; TREATMENT OUTCOME; VIROLOGY;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS; ANTIVIRAL AGENTS; DRUG INTERACTIONS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERFERONS; MUTATION; PREDNISOLONE; TREATMENT OUTCOME; VIRAL CORE PROTEINS;

EID: 0034185451     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80253-6     Document Type: Article

References (27)

1. Liaw YF, Tai DI, Chu CM, Chen TJ. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology. 8:1988;493-496.
2. Chu CM, Shyu WC, Kuo RW, Liaw YF. HLA class I antigen display on hepatocyte membrane in chronic hepatitis B virus infection: its role in the pahogenesis of chronic type B hepatitis. Hepatology. 7:1987;1311-1316.
3. Liaw YF, Tai DI, Chu CM, Lin DY, Sheen IS, Chen TJ, et al. Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis. A prospective study. Gastroenterology. 90:1986;263-267.
4. Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med. 119:1993;312-323.
5. Cohard M, Poynard T, Mathurin P, Zarski JP. Prednisone-interferon combination in the treatment of chronic of chronic hepatits B: Direct and indirect meta-analysis. Hepatology. 20:1994;1390-1398.
6. Liaw YF. Current trends in therapy for chronic viral hepatitis. J Gastroenterol Hepatol. 12:((Suppl)):1997;S346-S353.
7. Liaw YF, Lin SM, Chen TJ, Chien RN, Sheen IS, Chu CM. Beneficial effect of prednisolone withdrawal followed by human lymphoblastoid interferon on the treatment of chronic type B hepatitis in Asians: a randomized controlled trial. J Hepatol. 20:1994;175-180.
8. Carman WF, Ferrao M, Lok ASF, Ma OC, Lai CL, Thomas HC. Precore sequence variation in Chinese isolates of hepatitis B virus. J Infect Dis. 165:1992;127-133.
9. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet. ii:1989;588-591.
10. Brunetto MR, Stemler M, Bonino F, Schodel F, Oliveri F, Rizzetto M, et al. A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol. 10:1990;258-261.
11. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol. 64:1990;1298-1303.
12. Brunetto MR, Giarin MM, Oliveri F, Chiaberge E, Baldi M, Alfarano A, et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA. 88:1991;4186-4190.
13. Lok ASF, Akarca US, Greene S. Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance. Hepatology. 21:1995;19-24.
14. Fattovich G, McIntyre G, Thursz M, Colman K, Giuliano G, Alberti A, et al. Hepatitis B virus precore/core variation and interferon therapy. Hepatology. 22:1995;1355-1362.
15. Laskus T, Rakela J, Persing DH. Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon. Dig Dis Sci. 40:1995;1-7.
16. Brunetto MR, Giarin M, Saracco G, Oliveri F, Calvo P, Capra G, et al. Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B. Gastroenterology. 105:1993;845-850.
17. Günther S, Meisel H, Reip A, Miska S, Krüger DH, Will H. Frequent and rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment. Virology. 187:1992;271-279.
18. Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, et al. Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy. Hepatology. 12:1990;1284-1289.
19. Xu J, Brown D, Harrison T, Lin Y, Dusheiko G. Absence of hepatitis B virus precore mutants in patients with chronic hepatitis B responding to interferon-alpha. Hepatology. 15:1992;1002-1006.
20. How W, Ng WC, Tan MF, Seet BL, Guan R. Viral nucleotide changes in asymptomatic hepatitis B carriers undergoing interferon treatment. Aliment Pharmacol Ther. 10:1996;199-202.
21. Lopez-Alcorocho JM, Cabrerizo M, Bartolome J, Cotonat T, Carreno V. Analysis of hepatitis B virus precore variants in hepatitis B e antibody-positive patients treated with prednisone plus interferon. J Viral Hepat. 2:1995;279-284.
22. Chu CM, Yeh CT, Chiu CT, Sheen IS, Liaw YF. Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic. J Clin Microbiol. 34:1996;1815-1818.
23. Yeh CT, Chu CM, Liaw YF. Progression of the proportion of hepatitis B virus precore stop mutant following acute superinfection of hepatitis C. J Gastroenterol Hepatol. 13:1998;19-24.
24. Yeh CT, Chen TC, Shyu WC, Chien RN, Chu CM, Liaw YF. Quantitative assessment of serum hepatitis B virus DNA: comparison between two different methods. Hepatol Res. 7:1997;159-167.
25. Tur-Kaspa R, Burk RD, Shaul Y, Shafritz DA. Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc Natl Acad Sci USA. 83:1986;1627-1631.
26. Chuang WL, Omata M, Ehaa T, Yokosuka O, Hosoda K, Imazeki F, et al. Coinfection study of precore mutant and wildtype hepatitis B-like virus in ducklings. Hepatology. 19:1994;569-576.
27. Daikoku M, Nakata K, Hamasaki K, Ido A, Nakao K, Kato Y, et al. Analysis of wild-type and e antigen-defective hepatitis B viruses during the course of a short-term corticosteroid therapy in chronic hepatitis B. J Med Virol. 47:1995;184-188.