Somatotropin and adipose tissue metabolism: Substrate and temporal effects

Journal of Animal Science

Volumn 78, Issue 5, 2000, Pages 1236-1246

  Lee, K C ^a   Azain, M J ^a   Hausman, D B ^b   Ramsay, T G ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Adipose Tissue; Lipid Metabolism; Pigs; Somatotropin

Indexed keywords

SUIDAE; SUS SCROFA;

CARBON DIOXIDE; FATTY ACID; FATTY ACID SYNTHASE; GROWTH HORMONE; LACTIC ACID; PALMITIC ACID DERIVATIVE;

ADIPOSE TISSUE; ANIMAL; ARTICLE; CALORIC INTAKE; GROWTH, DEVELOPMENT AND AGING; LIPID METABOLISM; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SWINE; TIME; UREA NITROGEN BLOOD LEVEL;

ADIPOSE TISSUE; ANIMALS; BLOOD UREA NITROGEN; CARBON DIOXIDE; ENERGY INTAKE; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS, NONESTERIFIED; GROWTH HORMONE; LACTIC ACID; LIPID METABOLISM; MALE; OXIDATION-REDUCTION; PALMITATES; SWINE; TIME FACTORS;

EID: 0034184885     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2000.7851236x     Document Type: Article

References (32)

1. Azain, M. J., K. D. Bullock, T. R. Kasser, and J. J. Veenhuizen. 1992. Relationship of mode of porcine somatotropin administration and dietary fat to the growth performance and carcass characteristics of finishing pigs. J. Anim. Sci. 70:3086-3095.
2. Azain, M. J., D. B. Hausman, T. R. Kasser, and R. J. Martin. 1995. Effect of somatotropin and feed restriction on body composition and adipose tissue metabolism in obese Zucker rats. Am. J. Physiol 269:E137-E144.
3. Azain, M. J., and R. J. Martin. 1983. Effect of genetic obesity on the regulation of hepatic fatty acid metabolism. Am. J. Physiol. 244:R400-R406.
4. Azain, M. J., R. W. Seerley, J. O. Reagan, and M. K. Anderson. 1991. Effect of a high-fat diet on the performance response to porcine somatotropin (PST) in finishing pigs. J. Anim. Sci. 69:153-161.
5. Beauville, M., F. Harant, F. Crampes, M. Riviere, T. Tauber, J. P. Tauber, and M. Garrigues. 1992. Effect of long-term rhGH administration in GH-deficient adults on fat cell epinephrine response. Am. J. Physiol. 263:E467-E472.
6. Daughaday, W. H., I. K. Mariz, and S. L. Blethen. 1980. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: A comparison of radio receptor and radioimmunoassay in native and acid-ethanol extracted serum. J. Clin. Endocrinol. & Metab. 51:781-788.
7. Dunshea, F. R., D. E. Bauman, R. D. Boyd, and A. W. Bell. 1992a. Temporal response of circulating metabolites and hormones during somatotropin treatment of growing pigs. J. Anim. Sci. 70:123-131.
8. Dunshea, F. R., D. M. Harris, D. E. Bauman, R. D. Boyd, and A. W. Bell. 1992b. Effect of porcine somatotropin on in vivo glucose kinetics and lipogenesis in growing pigs. J. Anim. Sci. 70:141-151.
9. Dunshea, F. R., D. M. Harris, D. E. Bauman, R. D. Boyd, and A. W. Bell. 1992c. Effect of somatotropin on nonesterified fatty acid and glycerol metabolism in growing pigs. J. Anim. Sci. 70:132-140.
10. Harris, D. M., and D. E. Bauman. 1994. Time course of decrease in adipose tissue lipogenesis with porcine somatotropin (pST) treatment. J. Anim. Sci. 72(Suppl. 1):209 (Abstr.).
11. Harris, D. M., F. R. Dunshea, D. E. Bauman, R. D. Boyd, S.-Y. Wang, P. A. Johnson, and S. D. Clarke. 1993. Effect of in vivo somatotropin treatment of growing pigs on adipose tissue lipogenesis. J. Anim. Sci. 71:3293-3300.
12. Klindt, J., F. C. Buonomo, J. T. Yen, W. G. Pond, and H. J. Mersmann. 1995. Administration of porcine somatotropin by daily injection: Growth and endocrine responses in genetically lean and obese barrows and gilts. J. Anim. Sci. 73:3294-3303.
13. Lee, K. C., M. J. Azain, M. D. Hardin, and S. E. Williams. 1994. Effect of porcine somatotropin (pST) treatment and withdrawal on performance and adipose tissue cellularity in finishing swine. J. Anim. Sci. 72:1702-1711.
14. Magri, K. A., M. Adamo, D. Leroith, and T. D. Etherton. 1990. The inhibition of insulin action and glucose metabolism by porcine growth hormone in porcine adipocytes is not the result of any decrease in insulin binding of insulin receptor kinase activity. Biochem. J. 266:107-113.
15. Mersmann, H. J. 1983. Effect of anesthetic or analgesic drugs on lipogenic and lipolytic adipose tissue activities. Proc. Soc. Exp. Biol. Med. 172:375-378.
16. Mersmann, H. J., and M. D. MacNeil. 1986. Variables in estimation of adipocyte size and number with a particle counter. J. Anim. Sci. 62:980-991.
17. NRC. 1994. Metabolic Modifiers: Effects on the Nutrient Requirements of Food-Producing Animals. National Academy Press, Washington, BC.
18. Nepokroeff, C. M., M. R. Lakshmanan, and J. W. Porter. 1975. Fatty acid synthase from rat liver. Methods Enzymol. 35:37-44.
19. Newton, R. S., and R. A. Freedland. 1980. The effects of specific lipogenic substrates and metabolic inhibitors on de novo fatty acid synthesis in isolated hepatocytes from chow-fed female rats. Arch. Biochem. Biophys. 204:379-386.
20. O'Hea, E. K., and G. A. Leveille. 1969. Significance of adipose tissue and liver as sites of fatty acid synthesis in the pig and the efficiency of utilization of various substrates for lipogenesis. J. Nutr. 99:338-344.
21. Pullen, D. L., J. S. Liesman, and R. S. Emery. 1990. A species comparison of liver slice synthesis and secretion of triacylglycerol from nonesterified fatty acids in media. J. Anim. Sci. 68:1395-1399.
22. Ramsay, T. G., I. B. Chung, S. M. Czerwinski, J. P. McMurtry, R. W. Rosebrough, N. C. Steele. 1995. Tissue IGF-I protein and messenger RNA responses to a single injection of somatotropin. Am. J. Physiol. (Endo. Metab. 32):E627-E635.
23. Roberts, T. J., and M. J. Azain. 1995. Effect of somatotropin on rate and composition of gain and feed intake in young, pituitary intact female rats. Growth Dev. Aging 59:3-13.
24. Roberts, T. J., and M. J. Azain. 1997. Somatotropin treatment reduces energy intake without altering protein intake in pigs selecting between high and low protein diets. J. Nutr. 127:2047-2053.
25. SAS. 1985. SAS User's Guide: Statistics (Version 5 Ed.). SAS Inst. Inc., Cary, NC.
26. Smith, V. G., and C. W. Kasson. 1990. Growth performance and carcass characteristics of pigs administered recombinant porcine somatotropin during 30 to 110 kilogram of live weight. J. Anim. Sci. 68:4109-4116.
27. Thiel, L. F., D. H. Beermann, B. J. Krick, and R. D. Boyd. 1993. Dose-dependent effects of exogenous porcine somatotropin on the yield, distribution, and proximate composition of carcass tissues in growing pigs. J. Anim. Sci. 71:827-835.
28. Walton, P. E., and T. D. Etherton. 1986. Stimulation of lipogenesis by insulin in swine adipose tissue: Antagonism by porcine growth hormone. J. Anim. Sci. 62:1584-1595.
29. Walton, P. E., T. D. Etherton, and C. S. Chung. 1987. Exogenous pituitary and recombinant growth hormones induce insulin and insulin-like growth factor I resistance in pig adipose tissue. Domest. Anim. Endocrinol. 4:183-189.
30. Walton, P. E., T. D. Etherton, and C. M. Evock. 1986. Antagonism of insulin action in cultured pig adipose tissue by pituitary and recombinant porcine growth hormone: Potentiation by hydrocortisone. Endocrinology 118:2577-2581.
31. Wolverton, C. K., M. J. Azain, J. Y. Duffy, M. E. White, T. G. Ramsay. 1992. Influence of somatotropin on lipid metabolism in IGF gene expression in porcine adipose tissue. Am. J. Physiol. 263:E637-E645.
32. Wray-Cahen, D., D. A. Ross, D. E. Bauman, and R. D. Boyd. 1991. Metabolic effects of porcine somatotropin: Nitrogen and energy balance and characterization of the temporal pattern of blood metabolites and hormones. J. Anim. Sci. 69:1503-1514.