Ventricular unloading and myocyte recovery: Insight gained into the pathophysiology of congestive heart failure

Current Cardiology Reports

Volumn 2, Issue 3, 2000, Pages 181-188

  Margulies, Kenneth B ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL; CONGESTIVE HEART FAILURE; CYTOLOGY; ENERGY METABOLISM; HEART ASSIST DEVICE; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HEMODYNAMICS; HUMAN; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVIEW;

ANIMALS; CYTOKINES; ENERGY METABOLISM; HEART FAILURE, CONGESTIVE; HEART-ASSIST DEVICES; HEMODYNAMIC PROCESSES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHOSPHORYLATION; VENTRICULAR FUNCTION, LEFT;

EID: 0034182442     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-000-0067-5     Document Type: Article

References (45)

1. Katz AM: Cardiomyopathy of overload: a major determinant of prognosis in congestive heart failure. N Engl J Med 1990, 322:100-110.
2. Wieselthaler GM, Schima H, Hiesmayr M, et al. : First clinical experience with the DeBakey VAD continuous-axial-flow pump for bridge to transplantation. Circulation 2000, 101:356-350.
3. Nakatani S, McCarthy PM, Kottke-Marchant K, et al. : Left ventricular echocardiographic and histologic changes: impact of chronic unloading by an implantable ventricular assist device. J Am Coll Cardiol 1996, 27:894-901.
4. James KB, McCarthy PM, Thomas JD, et al. : Effect of the implantable left ventricular assist device on neuroendocrine activation in heart failure. Circulation 1995, 92(suppl II): II-191-II-195.
5. Levin HR, Oz MC, Chen JM, et al. : Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. Circulation 1995, 91:2717-2720.
6. Altemose GT, Gritsus V, Jeevanandam V, et al. : Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy. J Heart Lung Transplant 1997, 16:765-773.
7. Zafeiridis A, Jeevanandam V, Houser SR, Margulies KB: Regression of cellular hypertrophy after left ventricular assist device support. Circulation 1998, 98:656-662.
8. Grossman W, Jones D, McLaurin LP: Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 1975, 56:56-74.
9. Ito H, Hirata Y, Adachi S, et al. : Endothelin-I is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 1993, 92:398-403.
10. Schunkert H, Sadoshima J, Cornelius T, et al. : Angiotensin II-induced growth responses in isolated adult rat hearts: evidence for load-independent induction of cardiac protein synthesis by angiotensin II. Circ Res 1995, 76:489-497.
11. Long CS, Kariya K, Karns L, Simpson PC: Sympathetic modulation of the cardiac myocyte phenotype: studies with a cell-culture model of myocardial hypertrophy. Basic Res Cardiol 1992, 87(suppl 2):19-31.
12. Pfeffer MA, Lamasd GA, Vaughan DE, et al. : Effect of captopril on progressive left ventricular dilatation after anterior myocardial infarction. N Engl J Med 1988, 319:80-86.
13. Greenberg B, Quinones MA, Koilpillai C, et al. : Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction: results of the SOLVD echocardiography study. Circulation 1997, 91:2573-2581.
14. Hall SA, Cigarroa CG, Marcoux L, et al. : Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with betaadrenergic blockade. J Am Coll Cardiol 1995, 25:1154-1161.
15. Doughty RN, Whalley GA, Gamble G, et al. : Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. J Am Coll Cardiol 1997, 29:1060-1066.
16. Levine TB, Levine AB, Keteyian SJ, et al. : Reverse remodeling in heart failure with intensification of vasodilator therapy. Clin Cardiol 1997, 20:697-702.
17. Spinale FG, Ishihra K, Zile M, et al. : Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overload. Thorac Cardiovasc Surg 1993, 106:1147-1157.
18. Tamura T, Onodera T, Said S, Gerdes AM: Correlation of myocyte lengthening to chamber dilation in the spontaneously hypertensive heart failure (SHHF) rat. J Mol Cell Cardiol 1998, 30:2175-2181.
19. Dipla K, Mattiello JA, Jeevanandam V, et al. : Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation 1998, 97:2316-2322.
20. Li S, Margulies KB, Cheng H, Houser SR: Calcium current and calcium transients are depressed in failing human ventricular myocytes and recover in patients supported with left ventricular assist devices. Circulation 1999, 100:I-60-I-61.
21. Frazier OH, Benedict CR, Radovancevic B, et al. : Improved left ventricular function after chronic left ventricular unloading. Ann Thorac Surg 1996, 62:675-682.
22. Hisamatsu Y, Jayaraman T, Marx SO, et al. : Identification and characterization of the FKBP12, 6 binding site on cardiac RyR2. Circulation 1999, 100:I-772.
23. Bristow M, Gilbert EM: Improvement in cardiac myocyte function by biological effects of medical therapy: a new concept in the treatment of heart failure. Eur Heart J 1995, 16 (suppl F):20-31.
24. Mulieri LA, Hasenfuss G, Leavitt B, et al. : Altered myocardial force-frequency relationship in working myocardium from patients with end-stage heart failure. J Appl Cardiol 1988, 85:1743-1750.
25. Pieske B, Maier LS, Bers DM, Hasenfuss G: Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium. Circ Res 1999, 85:38-46.
26. Eichhorn DJ, Bedotto JB, Malloy CR, et al. : Effect of b-adrenergic blockade on myocardial function and energetics in congestive heart failure. Circulation 1990, 82:473-483.
27. Muller J, Wallukat G, Weng Y, et al. : Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation 1997, 96:542-549.
28. Lee SH, Doliba N, Osbakken M, et al. : Improvement of myocardial mitochondrial function after hemodynamic support with left ventricular assist devices in patients with heart failure. J Thorac Cardiovasc Surg 1998, 116:344-349.
29. Depre C, Shipley GL, Chen W, et al. : Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature Medicine 1998, 4:1269-1275.
30. Depre C, Shipley GL, Frazier OH, et al. : Reprogramming of dysfunctional gene expression after mechanical unloading in failing human heart. Circulation 1999, 100:I-802.
31. Heerdt PM, Choudhri AF: Left ventricular assist devices promote mitochondrial remodeling in ischemic but no idiopathic dilated cardiomyopathy. Circulation 1999, 100:I-167.
32. Torre-Amione G, Kapadia S, Lee J, et al. : Tumor necrosis factor-a and tumor necrosis factor receptors in the failing human heart. Circulation 1996, 93:704-711.
33. Testa M, Yeh M, Lee P, et al. : Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J Am Coll Cardiol 1996, 28:964-971.
34. Kapadia S, Oral H, Lee J, et al. : Hemodynamic regulation of tumor necrosis factor-a gene and protein expression in adult feline myocardium. Circ Res 1997, 81:187-195.
35. Belland SE, Jeevanandam V, Eisen HJ: Sustained mechanical support with left ventricular assist devices reduces tumor necrosis factor-a in conjunction with myocardial matrix metalloproteinases-1 and-2 expression in patients with severe dilated cardiomyopathy. Circulation 1998, 98:I-829.
36. Torre-Amione G, Stetson SJ, Youker KA, et al. : Decreased expression of tumor necrosis factor-a in failing human myocardium after mechanical circulatory support: a potential mechanism for cardiac recovery. Circulation 1999, 100:1189-1193.
37. Chen JM, Spanier TB, Gonzalez JJ, et al. : Improved survival in patients with acute myocarditis using external pulsatile mechanical ventricular assistance. J Heart Lung Transplant 1999, 18:351-357.
38. Bartling B, Milting H, Schumann H, et al. : Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure. Circulation 1999, 100(suppl II):II-216-II-223.
39. Malhotra R, Sadoshima J, Brosius FC III, Izumo S: Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes in vitro. Circ Res 1999, 85:137-146.
40. Yamazaki T, Komuro I, Yazaki Y: Molecular mechanism of cardiac cellular hypertrophy by mechanical stress. J Mol Cell Cardiol 1995, 27:133-140.
41. McCarthy PM, Nakatani S, Vargo R, et al. : Structural and left ventricular histologic changes after implantable LVAD insertion. Ann Thorac Surg 1995, 59:609-613.
42. Kent RL, Uboh CE, Thompson EW, et al. : Biochemical and structural correlates in unloaded and reloaded cat myocardium. J Mol Cell Cardiol 1985, 17:153-165.
43. Kinoshita MT: Influence of prolonged ventricular assistance on myocardial histopathology in intact heart. Ann Thorac Surg 1966, 61:640-645.
44. McElmurray JH 3rd, Mukherjee R, New RB, et al. : Angiotensinconverting enzyme and matrix metalloproteinase inhibition with developing heart failure. J Pharm Exp Ther 1999, 291:799-811.
45. Li YY, McTiernan CF, Feldman AM: Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. Cardiovasc Res 1999, 42:162-172.