Nuclear accumulation of p53 protein in gastric cancer strongly correlates with enlargement of Nuclear Area of cancer cells

Oncology Reports

Volumn 7, Issue 3, 2000, Pages 579-584

  Ikeguchi, Masahide ^a   Oka, Shinichi ^a   Saito, Hiroaki ^a   Kondo, Akira ^a   Tsujitani, Shunichi ^a   Maeta, Michio ^a   Kaibara, Nobuaki ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Gastric cancer; Nuclear area; p53 expression; Venous invasion

Indexed keywords

DNA; ENDOTHELIAL CELL GROWTH FACTOR; KI 67 ANTIGEN; LYMPHOKINE; PROTEIN P53; VASCULOTROPIN; VASCULOTROPIN A;

ARTICLE; CANCER INVASION; CANCER STAGING; CELL NUCLEUS; FEMALE; GASTRECTOMY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MICROCIRCULATION; MIDDLE AGED; MITOSIS INDEX; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PLOIDY; RETROSPECTIVE STUDY; STOMACH TUMOR; VASCULARIZATION;

CELL NUCLEUS; DNA, NEOPLASM; ENDOTHELIAL GROWTH FACTORS; FEMALE; GASTRECTOMY; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LYMPHATIC METASTASIS; LYMPHOKINES; MALE; MICROCIRCULATION; MIDDLE AGED; MITOTIC INDEX; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PLOIDIES; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034181938     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.7.3.579     Document Type: Article

References (26)

1. Haraguchi M, Watanabe A, Moriguchi S, Korenaga D, Maehara Y, Okamura T and Sugimachi K: DNA ploidy is a major prognostic factor in advanced gastric carcinoma-univariate and multivariate analysis. Surgery 110: 814-819, 1991.
2. Tsugawa K, Fushida S and Yonemura Y: Amplification of the c-erbB-2 gene in gastric carcinoma: correlation with survival. Oncology 50: 418-425, 1993.
3. Gabbert HE, Müller W, Schneiders A, Meier S and Hommel G: The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma. Cancer 76: 720-726, 1995.
4. Rubio CA and Porwit-McDonald A: A method to quantitate the relative nuclear area of colorectal polyps by image analysis. Anal Quant Cytol Histol 13: 155-158, 1991.
5. Skjorten F, Kaaresen R, Jacobsen U, Skaane P and Amlie E: Nuclear morphometry of benign and malignant breast lesions. Eur J Surg Oncol 17: 350-353, 1991.
6. Salmon I, Kiss R, Franc B, Gasperin P, Heimann R, Pasteels J-L and Verhest A: Comparison of morphonuclear features in normal, benign and neoplastic thyroid tissue by digital cell image analysis. Anal Quant Cytol Histol 14: 47-54, 1992.
7. Ladekarl M: Quantitative histopathology in ductal carcinoma of the breast. Cancer 75: 2114-2122, 1995.
8. Aaltomaa S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E and Syrjanen K: The significance of nuclear morphometric variables as prognostic predictors in breast cancer. Anticancer Res 11: 1663-1669, 1991.
9. Ruiz JL, Hernandez M, Martinez J, Vera C and Jimenez-Cruz JF: Value of morphometry as an independent prognostic factor in renal cell carcinoma. Eur Urol 27: 54-57, 1995.
10. Fukuzawa S, Hashimura T, Sasaki M, Yamabe H and Yoshida O: Nuclear morphometry for improved prediction of the prognosis of human bladder carcinoma. Cancer 76: 1790-1796, 1995.
11. Ikeguchi M, Sato N, Hirooka Y and Kaibara N: Computerized nuclear morphometry of hepatocellular carcinoma and its relation to proliferative activity. J Surg Oncol 68: 225-230, 1998.
12. Japanese Research Society for Gastric Cancer: The General Rules for the Gastric Cancer Study. 1st English edition. Kanehara, Tokyo, 1995.
13. Mitmaker B, Begin LR and Gordon PH: Nuclear shape as a prognostic discriminant in colorectal carcinoma. Dis Colon Rectum 34: 249-259, 1991.
14. Kawai K, Serizawa A, Hamana T and Tsutsumi Y: Heat-induced antigen retrieval of proliferating cell nuclear antigen and p53 protein in formalin-fixed, paraffin-embedded sections. Pathol Int 44: 759-764, 1994.
15. Maeda K, Chung Y-S, Ogawa Y, Takatsuka S, Kang S-M, Ogawa M, Sawada T and Sowa M: Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77: 853-863, 1996.
16. Bochner BH, Esrig D, Groshen S, Dickinson M, Weidner N, Nichols PW, Skinner DG and Cote RJ: Relationship of tumor angiogenesis and nuclear p53 accumulation in invasive bladder cancer. Clin Cancer Res 3: 1615-1622, 1997.
17. Tanigawa N, Amaya H, Matsumura M, Shimomatsuya T, Horiuchi T, Muraoka R and Iki M: Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric cancer. Cancer Res 56: 2671-2676, 1996.
18. Baak JPA, Ladekarl M and Sørensen FB: Reproducibility of mean nuclear volume and correlation with mean nuclear area in breast cancer. Hum Pathol 25: 80-85, 1994.
19. Kuo S-H, Lai M-Y, Liu Y-R, Lee Y-T, Chen D-S, Lee C-S and Hsu H-C: Nuclear area and DNA content in tumor and non-tumor portions of hepatocellular carcinoma. Anal Quant Cytol Histol 16: 153-158, 1994.
20. Cagle PT, Langston C, Fraire AE, Roggli VL and Greenberg SD: Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma. Cancer 69: 2454-2457, 1992.
21. Pienta KJ and Coffey DS: Correlation of nuclear morphometry with progression of breast cancer. Cancer 68: 2012-2016, 1991.
22. Hamilton PW, Wyatt JI, Quirke P, Watt PCH, Arthur K, Ward DC and Johnston D: Morphometry of gastric carcinoma: its association with patient survival, tumor stage, and DNA ploidy. J Pathol 168: 201-208, 1992.
23. Haapasalo H, Atkin NB, Collan Y, Pesonen E and Paljarvi L: Tumour ploidy, morphometry, histological grading and clinical features in ovarian carcinoma: mutual relations. Anal Cell Pathol 3: 261-271, 1991.
24. Mulder J-WR, Offerhaus GJA, de Feyter EP, Floyd JJ, Kern SE, Vogelstein B and Hamilton SR: The relationship of quantitative nuclear morphology to molecular genetic alterations in the adenoma-carcinoma sequence of the large bowel. Am J Pathol 141: 797-804, 1992.
25. Martin R, Nieto S and Santamaria L: Stereologic estimates of volume-weighted mean nuclear volume in colorectal adenocarcinoma: correlation with histologic grading, Dukes' staging, cell proliferation activity and p53 protein expression. Gen Diagn Pathol 143: 29-38, 1997.
26. Talve L, Kainu J, Collan Y and Ekfors T: Immunohistochemical expression of p53 protein, mitotic index and nuclear morphometry in primary malignant melanoma of the skin. Pathol Res Pract 192: 825-833, 1996.