Synthesis and in vivo evaluation of (E)-N-[11C]methyl-4(3-pyridinyl)-3-butene-l-amine ([11C]metanicotine) as a nicotinic receptor radioligand

Nuclear Medicine and Biology

Volumn 27, Issue 4, 2000, Pages 415-418

  Brown Proctor, Clive ^a   Snyder, Scott E ^a   Sherman, Phillip S ^a   Kilbourn, Michael R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Carbon 11; Emission computed; Metanicotine; Tomography

Indexed keywords

METANICOTINE C 11; NICOTINIC RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG; CARBON; DIAGNOSTIC AGENT; DRUG DERIVATIVE; METANICOTINE; NICOTINE; NICOTINIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; MONKEY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; ANIMAL; BINDING COMPETITION; BRAIN LEVEL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; MACACA; METABOLISM;

ANIMALS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CARBON RADIOISOTOPES; FEMALE; MACACA NEMESTRINA; MICE; NICOTINE; NICOTINIC AGONISTS; RECEPTORS, NICOTINIC; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034180859     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00091-3     Document Type: Article

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