Treatment strategies for Aspergillus infections

Drug Resistance Updates

Volumn 3, Issue 2, 2000, Pages 89-97

  Chiller, Tom M ^a,b   Stevens, David A ^a,b  

^a SANTA CLARA VALLEY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ABPA; Antifungal therapy; Aspergilloma; Aspergillus; Invasive aspergillosis

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B CHOLESTEROL SULFATE; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; CASPOFUNGIN; DEOXYCHOLIC ACID; ITRACONAZOLE; MICAFUNGIN; NYSTATIN; POSACONAZOLE; RAVUCONAZOLE; VORICONAZOLE;

ASPERGILLOSIS; ASPERGILLUS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFECTION RISK; META ANALYSIS; MORTALITY; NEPHROTOXICITY; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; SHORT SURVEY; VIRULENCE;

EID: 0034178009     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2000.0133     Document Type: Article

References (97)

1. Warnock, DW, Arthington-Skaggs, BA, Li, R-K. Antifungal drug susceptibility testing and resistance in Aspergillus. Drug Resist Updates 1999;2:326-334.
2. Aisner J, Schimpff SC, Wiernik PH. Treatment of invasive aspergillosis: relation of early diagnosis and treatment to response. Ann Intern Med. 1977;86:539-543.
3. von Eiff M, Roos N, Schulten R, Hesse M, Zuhlsdorf M, van de Loo J. Pulmonary aspergillosis: early diagnosis improves survival. Respiration 1995;62:341-347.
4. Caillot D, Casasnovas O, Bernard A, et al. Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J Clin Oncol 1997;15:139-147.
5. Denning DW, Stevens DA. Antifungal and surgical treatment of invasive aspergillosis: Review of 2,121 published cases. Rev Infect Dis 1990;12:1147-1201.
6. Gurwith MJ, Stinson EB, Remington JS. Aspergillus infection complicating cardiac transplantation. Arch Intern Med 1971;128:541-545.
7. Burch PA, Karp JE, Merz WG, Kuhlman JE, Fishman EK. Favorable outcome of invasive aspergillosis in patients with acute leukemia. J Clin Oncol 1987;5:1985-1993.
8. Denning DW. Therapeutic outcome in invasive aspergillosis. Clin Infect Dis 1996;23:608-615.
9. Lass-Florl C, Kofler G, Kropshofer G, et al. In vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. J Antimicrob Chemother 1998;42:497-502.
10. Walsh TJ, Hiemenz JW, Seibel N, et al. Amphotericin B lipid complex in patients with invasive fungal infections: analysis of safety and efficacy in 556 cases. Clin Infect Dis 1998;26:1383-1396.
11. Oppenheim BA, Herbrecht R, Kusne S. The safety and efficacy of amphotericin B colloidal dispersion in the treatment of invasive mycoses. Clin Infect Dis 1995;21:1145-1153.
12. Bowden RA, Cays M, Gooley T, Mamelok RD, van Burik JA. Phase 1 study of amphotericin B colloidal dispersion for the treatment of invasive fungal infections after marrow transplant. J Infect Dis 1996;173:1208-1215.
13. Ringden O., Meunier F., Tollemar J. Efficacy of amphotericin B encapsulated in liposomes (AmBisome) in the treatment of invasive fungal infections in immunocompromised patients. J Antimicrob Chemother. 28 suppl B:1991;73-82.
14. Mills W, Chopra R, Linch DC, Goldstone AH. Liposomal amphotericin B in the treatment of fungal infections in neutropenic patients: a single-centre experience of 133 episodes in 116 patients. Br J Haematol 1994;86:754-760.
15. Ng TTC, Denning DW. Liposomal amphotericin B (AmBisome) therapy in invasive fungal infections. Arch Intern Med 1995;155:1093-1098.
16. White MH, Anaissie EJ, Kusne S, et al. Amphotericin B colloidal dispersion vs. amphotericin B as therapy for invasive aspergillosis. Clin Infect Dis 1997;24:635-642.
17. Ellis M, Spence D., de Pauw B, et al. An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis. Clin Infect Dis. 1998;27:1406-1412.
18. Denning DW, Lee JY, Hostetler JS, et al. Mycoses Study Group multicenter trial of oral itraconazole therapy for invasive aspergillosis. Am J Med. 1994;97:135-144.
19. Stevens DA, Lee JY. Analysis of compassionate use itraconazole for invasive aspergillosis by the NIAID Mycoses Study Group criteria. Arch Intern Med 1997;157:1857-1862.
20. Denning DW, Tucker RM, Hanson LH, Stevens DA. Treatment of invasive aspergillosis with itraconazole. Am J Med 1989;86:791-800.
21. Viviani MA, Tortorano AM, Woestenborghs R, Cauwenbergh G. Experience with itraconazole in deep mycoses in northern Italy. Mykosen 1987;30:233-24.
22. Dupont B. Itraconazole therapy in aspergillosis: study in 49 patients. J Am Acad Dermatol 1990;23:607-614.
23. DeBeule K, DeDoncker P, Cauwenbergh G, et al. The treatment of aspergillosis and aspergilloma with itraconazole, clinical results of an open international study (1982-1987). Mycoses 1988;31:476-485.
24. Smith D, Van de Velde V, Woestenborghs R. The pharmacokinetics of oral itraconazole in AIDS patients. J Pharm Pharmacol 1992;44:618-619.
25. Stevens D.A. Itraconazole in cyclodextrin solution. Pharmacother 1999;19:603-611.
26. Denning DW, Hanson LH, Perlman AM, Stevens DA. In vitro susceptibility and synergy studies of Aspergillus species to conventional and new agents. Diag Micro Infect Dis 1992;15:21-34.
27. Schaffner A, Bohler A. Amphotericin B refractory aspergillosis after itraconazole: evidence for significant antagonism. Mycoses 1993;36:421-424.
28. Caillot D., Casasnovas O., Bernard A. Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J Clin Oncol 1997;15:139-147.
29. Pagano L., Ricci P., Nosari A, et al. Fatal haemoptysis in pulmonary filamentous mycosis: an underevaluated cause of death in patients with acute leukemia in hematological complete remission. A retrospective study and review of the literature. Br J Haematol. 89:1995;500-505.
30. Stevens DA. Combination immunotherapy and antifungal chemotherapy. Clin Infect Dis 1998;26:1266-1269.
31. Bhatia S, McCullough J, Perry EH, Clay M, Ramsay NKC, Neglia JP. Granulocyte transfusions: efficacy in treating fungal infections in neutropenic patients following bone marrow transplantation. Transfusion. 1994;34:226-232.
32. Yomtovian R., Abramson J., Quie P., McCullough J. Granulocyte transfusion therapy in chronic granulomatous disease: report of a patient and review of the literature. Transfusion. 21:1981;739-743.
33. Pui C-H, Boyett JM, Hughes WT, Crist WM. A randomized, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor after remission induction chemotherapy in children with acute lymphocytic leukemia. N Engl J Med 1997;336:1781-1787.
34. Nemunaitis J. Use of macrophage colony-stimulating factor in the treatment of fungal infections. Clin Infect Dis. 26:1998;1279-1281.
35. Vose JM, Bierman PJ, Kessinger A, et al. The use of recombinant human granulocyte-macrophage colony stimulating factor for the treatment of delayed engraftment following high dose therapy and autologous hematopoietic stem cell transplantation for lymphoid malignancies. Bone Marrow Transplant 1991;7:139-143.
36. Rowe JM. Treatment of acute myeloid leukemia with cytokines: effect on duration of neutropenia and response to infections. Clin Infect Dis. 1998;26:1290-1294.
37. Bernhisel-Broadbent J, Camargo EE, Jaffe HS, Lederman HM. Recombinant human interferon-γ as adjunct therapy for Aspergillus infection in a patient with chronic granulomatous disease. J Infect Dis. 1991;163:908-911.
38. Denning D., del Favero A., Gluckman E. The efficacy and tolerability of UK-109,496 (voriconazole), in the treatment of invasive aspergillosis. Proceedings of the 13th Congress of the International Society for Human and Animal Mycology, 1997;International Society for Human and Animal Mycology, Parma, Italy.
39. Bartizal K, Gill CJ, Abruzzo GK, et al. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L 743,872). Antimicrob Agents Chemother 1997;41:2326-2332.
40. Fraser, R. Pare, J. Pare, P. Frasier, R. Genereux, G. Diagnosis of diseases of the chest. 1988.
41. Kauffman C. Quandary about treatment of aspergillomas persists. Lancet. 347:1996;1640.
42. Jewkes J., Kay P., Paneth M., Citron K. Pulmonary aspergilloma: analysis of prognosis in relation to haemoptysis and survey of treatment. Thorax. 38:1983;572-578.
43. Kaplan J., Johns C. Mycetomas in pulmonary sarcoidosis: nonsurgical management. J Hopkins Med J. 145:1979;157-161.
44. Remy J., Arnaud A., Fardou H., Guraud R., Viosin C. Treatment of hemoptysis by embolization of bronchial arteries. Radiology. 122:1977;33-37.
45. Uflacker R., Laemmerer A., Neves C., Picon P. Management of massive hemoptysis by bronchial artery embolization. Radiology. 146:1983;627-634.
46. Jewkes J., Kay P., Paneth M., Citron K. Pulmonary aspergilloma: analysis of prognosis in relation to haemoptysis and survey of treatment. Thorax. 38:1983;572-578.
47. Shapiro M. J., Albelda S. M., Mayock R. L., McLean G. K. Severe hemoptysis associated with pulmonary aspergilloma: percutaneous intracavitary treatment. Chest. 1984:1988;1225-1231.
48. Yamada H., Kohno S., Koga H., Maesaki S., Kaku M. Topical treatment of pulmonary aspergilloma by antifungals. Chest. 103:1993;1421-1425.
49. Munk PL, Vellet AD, Rankin RN, Muller NL, Ahmad D. Intracavitary aspergilloma: transthoracic percutaneous injection of amphotericin gelatin solution. Radiology. 188:1993;821-823.
50. Davies D., Somner AR. Pulmonary aspergillomas treated with corticosteroids. Thorax. 27:1972;156-162.
51. Mrouch S., Spock A. Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Chest. 105:1994;32-36.
52. Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med. 86:1977;405-414.
53. Rosenberg M., Patterson R., Roberts M., Wang J. The assessment of immunologic and clinical changes occurring during corticosteroid therapy for allergic bronchopulmonary aspergillosis. Am J Med. 64:1978;599-605.
54. Safirstein BH, D'Souza MF, Simon G, Tai EHC, Pepys J. Five-year follow-up of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis. 108:1973;450-459.
55. Middleton WG, Paterson IC, Grant IWB, Douglas AC. Asthmatic pulmonary eosinophilia: a review of 65 cases. Br J Dis Chest. 71:1977;115-122.
56. Br J Dis Chest. 73:1979;349-356.
57. Radin RC, Greenberger PA, Patterson R, Ghory A. Mould counts and exacerbations of allergic bronchopulmonary aspergillosis. Clin Allergy. 13:1983;271-275.
58. Malo JL, Hawkins R, Pepys J. Studies in chronic allergic bronchopulmonary aspergillosis. 1: Clinical and physiological findings. Thorax. 32:1977;254-261.
59. Denning DW, Van Wye JE, Lewiston NJ, Stevens DA. Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. Chest. 100:1991;813-819.
60. Germaud P., Tuchais E. Allergic bronchopulmonary aspergillosis treated with itraconazole (letter). Chest. 107:1995;883.
61. Nepomuceno I, Esrig S, Moss RB. Allergic bronchopulmonary aspergillosis in cystic fibrosis. Role of atopy and response to itraconazole. Chest. 115:1999;364-370.
62. Stevens DA, Schwartz HJ, Lee JY, et al. A randomized double blind study of itraconazole in allergic bronchopulmonary aspergillosis. N Eng J Med. 342:2000;756-762.
63. DeShazo RD, Chapin K, Swain RE. Fungal sinusitis. N Eng J Med. 337:1997;254-259.
64. Kavanagh KT, Hughes WT, Parham DM, et al. Fungal sinusitis in immunocompromised children with neoplasms. Ann Oto Rhinol. 100:1991;331-336.
65. Iwen PC, Rupp ME, Hinrichs SH. Invasive mold sinusitis: 17 cases in immunocompromised patients and review of the literature. Clin Infect Dis. 24:1997;1178-1184.
66. Wiatrak BJ, Wilging P, Myer CM, et al. Functional endoscopic sinus surgery in the immunocompromised child. Otolaryngol Head Neck Surg. 105:1991;818-825.
67. Kusomoto S., Matusda A., Fukuda M. Aspergillosis of the maxillary sinus in a patient with Ph1 positive acute lymphoblastic leukemia: a case report. Rinsho Ketsueki. 31:1990;1512-1516.
68. Rothfield I, Eliot G, Begg CF. Aspergilloma of sinus. NY State J Med. 72:1972;493-495.
69. Grigoriv D., Bubmule J., Delacretaz J. Aspergillus sinusitis. Postgrad Med J. 55:1979;619-621.
70. Rudwan MA, Sheikh HA. Aspergilloma of paranasal sinuses - a common cause of unilateral proptosis in Sudan. Clin Radiol. 27:1976;479-502.
71. Stammberger H. Endoscopic surgery for mycotic and chronic recurring sinusitis. Ann Otol Rhinol Laryngol [Suppl]. 119:1985;1-11.
72. Sandison AT, Gentles JC, Davidson CM, et al. Aspergilloma of paranasal sinuses and orbit in a northern Sudanese. Sabouraudia. 6:1967;57-69.
73. Washburn RG, Kennedy DW, Begley MG, et al. Chronic fungal sinusitis in apparently normal hosts. Medicine. 67:1988;231-247.
74. Kemper CA, Hostetler JS, Follansbee SE, et al. Ulcerative and plaque-like tracheobronchitis due to infection with Aspergillus in patients with AIDS. Clin Infect Dis. 17:1993;344-352.
75. Bolivar R. Gomez WC., Luna M, et al. Aspergillus epiglottitis. Cancer. 51:1983;367-370.
76. Lortholary O, Meyohas M-C, Dupont B, et al. Invasive aspergillosis in patients with acquired immunodeficiency syndrome: Report of 33 cases. Am J Med. 95:1993;177-187.
77. Miller WT, Sais GJ, Frank I. et al. Pulmonary aspergillosis in patients with AIDS. Chest. 105:1994;37-44.
78. Kuo PH, Lee LN, Yang PC, Chen YC, Luh KT. Aspergillus laryngotracheobronchitis presenting as stridor in a patient with peripheral T cell lymphoma. Thorax. 51:1996;869-870.
79. Biggs VJ, Dummer S, Holsinger FC, Loyd JE, Christman BW, Frist WH. Successful treatment of invasive bronchial aspergillosis after single-lung transplantation. Clin Infect Dis. 18:1994;123-124.
80. Kramer MR, Denning DW, Marshall SE, et al. Ulcerative tracheobronchitis after lung transplantation. Am Rev Respir Dis. 144:1991;552-556.
81. Dal Conte I., Riva G., Obert R. Tracheobronchial aspergillosis in a patient with AIDS treated with aerosolized amphotericin B combined with itraconazole. Mycoses. 39:1996;371-374.
82. Cunningham M, Yu V.L, Turner J, et al. Necrotizing otitis externa due to Aspergillus in an immunocompetent host. Arch Otolaryngol Neck Surg. 114:1988;554-556.
83. Georgiev, VS. Aspergillus spp, in Infectious disease in immunocompromised hosts. CRC Press, Boca Raton, FL, 1009, 1057, 1998.
84. Walsh TJ, Caplan LR, Hier DB. Aspergillus infections of the central nervous system: a clinicopathological analysis. Ann Neurology. 18:1985;574-582.
85. Henze G, Aldenhoff P, Stephani U, et al. Successful treatment of pulmonary and cerebral aspergillosis in an immunosuppressed child. Eur J Pediatr. 138:1982;263-265.
86. Impens N., DeGreve J., Beule K., Meysman M., Beuckelaere S., Schandevyi W. Oral treatment with itraconazole of aspergilloma in cavitary lung cancer. Eur Respir Dis. 3:1990;837-839.
87. Sanchez C., Mauri E., Dalmau D., Quintana S., Aparicio A., Garau J. Treatment of cerebral aspergillosis with itraconazole: do high doses improve the prognosis? Clin Infect Dis. 21:1995;1485-1487.
88. Schwartz S., Milatovic D., Thiel E. Successful treatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leukaemia. Brit J Haematol. 97:1997;663-665.
89. Mikolich DJ, Kinsella LJ, Skowron G, Friedman J, Sugar AM. Aspergillus meningitis in an immunocompetent adult successfully treated with itraconazole. Clin Infect Dis. 23:1996;1318-1319.
90. Roney P, Barr C, Chun CH, et al. Endogenous Aspergillus endophthalmitis. Rev Infect Dis. 8:1986;955-958.
91. Ho PC, Tolentino FI, Baker AS. Successful treatment of exogenous aspergillus endophthalmitis: a case report. Br J Ophthalmol. 68:1984;412-415.
92. Snip RC, Michels RG. Pars Plana vitrectomy in the management of endogenous Candida endophthalmitis. Am J Ophthalmol. 82:1976;699-704.
93. Jones BR, Richards AB, Clayton YM. Clotrimazole in the treatment of ocular infection by Aspergillus fumigatus. Postgrad Med J. 50(suppl 1):1974;39-45.
94. Villard C, LaCroiz C, Rabot MH, Rovira JC, Jacquemin JL. Severe Aspergillus keratomycosis treated with itraconazole per os. J Fr Ophthalmol. 12:1989;323-325.
95. Flynn PM, Magill HL, Jenkins JJ, et al. Aspergillus osteomyelitis in a child treated for acute lymphoblastic leukemia. Pediatr Infect Dis J. 9:1990;733-736.
96. Barnwell PA, Jelsma LF, Raff MJ. Aspergillus osteomyelitis: Report of a case and review of the literature. Diagn Microbiol Infect Dis. 3:1985;515-519.
97. Holmes PF, Osterman DW, Tullos HS. Aspergillus discitis: Report of two cases and review of the literature. Clinical Orthop. 226:1988;240-246.