Steroid 5α-reductase inhibitory activity and hair regrowth effects of an extract from boehmeria nipononivea

Bioscience, Biotechnology and Biochemistry

Volumn 64, Issue 4, 2000, Pages 875-877

  Shimizu, Kuniyoshi ^a   Kondo, Ryuichiro ^a   Sakai, Kokki ^a   Shoyama, Yoshihiro ^a   Sato, Hiroaki ^b   Ueno, Tetsuya ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b Kansai Koso Co Ltd   (Japan)

Author keywords

Boehmeria nipononivea; Fatty acid; Hair regrowth; Testosterone 5cx reductase inhibitor; Urticaceae

Indexed keywords

ACETONE; ENZYME INHIBITOR; FATTY ACID; PLANT EXTRACT; STEROID 5ALPHA REDUCTASE;

ALOPECIA; ANGIOSPERM; ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; DRUG ANTAGONISM; GROWTH, DEVELOPMENT AND AGING; HAIR; MALE; MOUSE;

ACETONE; ALOPECIA; ANIMALS; ENZYME INHIBITORS; FATTY ACIDS; HAIR; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; ROSALES; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0034171346     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.64.875     Document Type: Article

References (8)

1. Bingham, K. D., and Shaw, D. A., The metabolism of testosterone by human male scalp skin. J. Endocrinol., 59, 111-121 (1973).
2. Schweikert, H. U., and Wilson, J. D., Regulation of human hair growth by steroid hormones. I. Testosterone metabolism in isolated hairs. J. Clin. Endocrinol. Metab., 38, 811-819 (1974).
3. Imperato-McGinley, J., Guerroro, L., Gautier, T., and Peterson, R. E., Steroid 5«-reductase deficiency in man: an inherited form of male pseudoher maphroditism. Science, 186, 1212-1215 (1974).
4. Rasmusson, G. H., Reynolds, G. F., Steinberg, N. G., Walton, E., Patel, G. F., Liang, T., Cascieri, M. A., Cheung, A. H., Brooks, J. R., and Berman, C., Azasteroids: structure-activity relationships for inhibition of 5«-reductase and of androgen receptor binding. J. Med. Chem., 29, 2298-2315 (1986).
5. McConnell, J. D., Wilson, J. D., George, F. W., Geller, J., Pappas, F., and Stoner, E., Finasteride, an inhibitor of 5«-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J. Clin. Endocrinol. Metab., 74, 505-508 (1992).
6. Rhodes, L., Harper, J., Uno, H., Gaito, G., Audette-arruda, J., Kurata, S., Berman, C., Primka, R., and Pikounis, B., The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides). J. Clin. Endocrinol. Metab., 79, 991-996 (1994).
7. Shimizu, K., Fukuda, M., Kondo, R., and Sakai, K., The 5«-reductase inhibitory components from heart-wood of Artocarpus incisus: Structure-activity investigations. Planta Med., 66, 16-19 (2000).
8. Liang, T., and Liao, S., Inhibition of steroid 5«-reduc-tase by specific aliphatic unsaturated fatty acids. Biochem. J., 285, 557-562 (1992)