The role of cytokines in UV-induced systemic immune suppression

Journal of Dermatological Science

Volumn 23, Issue SUPPL. 1, 2000, Pages

  Ullrich, Stephen E ^a   Schmitt, David A ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Antigen presenting cell; Immune suppression; Interleukin 10; Interleukin 12; UV radiation

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12;

ANTIGEN PRESENTING CELL; ARTICLE; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; PRIORITY JOURNAL; SKIN CANCER; T LYMPHOCYTE; ULTRAVIOLET RADIATION;

ANIMALS; ANTIGEN PRESENTATION; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-12; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0034162876     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(99)00073-0     Document Type: Article

References (10)

1. Kripke ML. Antigenicity of murine skin tumors induced by UV light. J Natl Cancer Inst 1974;53:1333-6.
2. Fisher MS, Kripke ML. Suppressor T-lymphocytes control the development of primary skin cancers in UV-irradiated mice. Science 1982;216:1133-4.
3. Streilein JW, Taylor JR, Vincek V, Kurimoto I, Shimizu T, Tie C, Colomb C. Immune surveillance and sunlight induced skin cancer. Immunol Today 1994;15:174-9.
4. Greene MI, Sy MS, Kripke ML, Benacerraf B. Impairment of antigen-presenting cell function by UV radiation. Proc Natl Acad Sci USA 1979;76:6591-5.
5. Krutmann JA, Khan IU, Wallis RS, Zhang F, Rich EA, Ellner JJ, Elmets CA. Cell membrane is the major locus for ultraviolet B-induced alterations in accessory cells. J Clin Invest 1990;85:1529-36.
6. Ullrich SE. Mechanism involved in the systemic suppression of antigen presenting cell function by UV irradiation: Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J Immunol 1994;152:3410-6.
7. Ullrich SE, Pride MW, Moodycliffe AM. Antibodies to the co-stimulatory molecule CD86 interfere with ultraviolet radiation-induced immune suppression. Immunology 1998;94:417-23.
8. Weiss JC, Renkl AC, Denfeld RW, de Roche R, Spitzlei M, Schopf E, Simon JC. Lowdose UVB radiation perturbs the functional expression of B7.1 and B7.2 co-stimulatory molecules on human Langerhans cells. Eur J Immunol 1995;25:2858-62.
9. Magram J, Connaughton SE, Warrier RR, Carvajal CM, Wu C-Y, Ferrante J, Stewart C, Sarmiento U, Faharty DA, Gately MK. IL-12-deficient mice are defective in IFN-( production and type 1 cytokine responses. Immunity 1996;4:471-81.
10. Okamoto H, Kripke ML. Effector and suppressor circuits of the immune response are affected in vivo by different mechanisms. Proc Natl Acad Sci USA 1987;84:3841-5.