Relationship between red cell mean corpuscular volume and 6-thioguanine nucleotides in patients treated with azathioprine

Journal of Laboratory and Clinical Medicine

Volumn 135, Issue 3, 2000, Pages 256-262

  Decaux, G ^a,b,c   Prospert, F ^a,b,c   Horsmans, Y ^a,b,c   Desager, J P ^a,b,c  

^a ERASME HOSPITAL   (Belgium)

^b Departement de Medecine Interne   (Luxembourg)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034162598     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1067/mlc.2000.105215     Document Type: Article

References (21)

1. 1. Elion GB. The purine path to chemotherapy. Science 1989;244:41-7.
2. 2. Elion GB. The pharmacology of azathioprine. Ann NY Acad Sci 1993;685:401-7.
3. 3. Tidd DM, Paterson ARP. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res 1974;34:738-46.
4. 4. Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
5. 5. Lennard L, Van Hoon JA, Lilleyman JS, Weinshilboum RM. Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 1987;41:18-25.
6. 6. Lennard L, Lilleyman JS, Van Hoon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990;336:225-9.
7. 7. Van Os EC, Zins BJ, Sandborn WJ, Mays DC, Tremaine WJ, Mahoney DW, et al. Azalhioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration. Gut 1996;39:63-8.
8. 8. Lennard L, Brown CB, Fox M, Maddock JL. Azathioprine metabolism in kidney transplant recipients. Br J Clin Pharmacol 1984;18:693-70 0.
9. 9. Schiegelow K, Kriegbaum NJ. 6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment. Ann Rheum Dis 1993;52:152-4.
10. 10. Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992;43:329-3 9.
11. 11. Sandborn WJ, Van Os EC, Zins BJ, Tremaine WJ, Mays DC, Lipsky JJ. An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease. Gastroenterology 1995;109:1808-1 7.
12. 12. Klippel JH, Decker JL. Relative macrocytosis in cyclophosphamide and azathioprine therapy. JAMA 1974;299: 180-1.
13. 13. Lennard L, Singleton HJ. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992;583:83-9 0.
14. 14. Weinshilboum RM, Raymond FA, Pazminno PA. Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 1978;85:323-3 3.
15. 15. McGrath BP, Ibels LS, Raik E, Margrave M, Mahony JF, Stewart JH. Erythroid toxicity of azathioprine. QJ Med 1975;44:57-6 3.
16. 16. Ronar J, Weshroelt F, Atrik N, Wetiby M. The occurrence of megaloblastic anemia with normal serum folate during antipurine therapy. Clin Res 1973;21:9 4.
17. 17. Bergan S, Rugstad HE, Bentdal O, et al. Monitored highdose azathioprine treatment reduces acute rejection episodes after renal transplantation. Transplantation 1998;66:334-9.
18. 18. Schütz E, Gummert J, Mohr FW, Armstrong VW, Oellerich M. Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine? Ther Drug Monit 1996;18:228-3 3.
19. 19. Pearson DC, May GR, Pick GH, Sutherland LR. Azathioprine in Crohn's disease: a meta-analysis. Ann Intern Med 1995;122:132-4 2.
20. 20. Matell G, Bergstrom K, Frankson C. Effect of some immunosuppressive procedures on myastenia gravis. Ann NY Acad Sci 1976;274:659-8 2.
21. 21. Mason M, Currey HLF, Barnes CG. Azathioprine in rheumatoid arthritis. Br Med J 1969;1:420-2.