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Volumn 60, Issue 5, 2000, Pages 1186-1188

Further evidence that the radioprotective aminothiol, WR-1065, catalytically inactivates mammalian topoisomerase II

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CLASTOGEN; CLINAFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ECHINOMYCIN; ETOPOSIDE; MITOMYCIN C; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RADIOPROTECTIVE AGENT;

EID: 0034161975     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (10)
  • 1
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    • Radioprotective effects of amifostine
    • Wasserman, T. Radioprotective effects of amifostine. Semin. Oncol., 26: 89-94, 1999.
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    • Wasserman, T.1
  • 2
    • 0002449512 scopus 로고
    • Radioprotectants
    • J. J. Conklin and R. I. Walker (eds.), Orlando, FL: Academic Press, Inc.
    • Giambarresi, L., and Jacobs A. J. Radioprotectants. In: J. J. Conklin and R. I. Walker (eds.), Mililary Radiobiology, pp. 265-301. Orlando, FL: Academic Press, Inc., 1987.
    • (1987) Mililary Radiobiology , pp. 265-301
    • Giambarresi, L.1    Jacobs, A.J.2
  • 3
    • 0021796650 scopus 로고
    • The radioprotector WR-1065 reduces radiation-induced mutagenesis at the hypoxanthine guanine phosphoribosyl transferase locus in V79 cells
    • Lond.
    • Grdina, D. J., Nagy, B., Hill, C K., Wells, R. L., and Peraino, C. The radioprotector WR-1065 reduces radiation-induced mutagenesis at the hypoxanthine guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis (Lond.), 6: 929-931, 1985.
    • (1985) Carcinogenesis , vol.6 , pp. 929-931
    • Grdina, D.J.1    Nagy, B.2    Hill, C.K.3    Wells, R.L.4    Peraino, C.5
  • 4
    • 0023835130 scopus 로고
    • 2-[(Aminopropyl)amino] ethanethiol mediated reductions in Co-60 γ ray and fission spectrum neutron induced chromosome damage in V79 cells
    • Schwartz, J. L., Giovanazzi, S. M., Karrison, T., Jones, C. and Grdina, D. J. 2-[(Aminopropyl)amino] ethanethiol mediated reductions in Co-60 γ ray and fission spectrum neutron induced chromosome damage in V79 cells. Radiat. Res., 113: 145-154, 1988.
    • (1988) Radiat. Res. , vol.113 , pp. 145-154
    • Schwartz, J.L.1    Giovanazzi, S.M.2    Karrison, T.3    Jones, C.4    Grdina, D.J.5
  • 5
    • 0028343712 scopus 로고
    • Inhibition of topoisomerase II α activity in CHO K1 cells by WR1065
    • Grdina, D. J., Constantinou, A., Shigematsu, N., and Murley, J. Inhibition of topoisomerase II α activity in CHO K1 cells by WR1065. Radiat. Res., 138: 44-52, 1994.
    • (1994) Radiat. Res. , vol.138 , pp. 44-52
    • Grdina, D.J.1    Constantinou, A.2    Shigematsu, N.3    Murley, J.4
  • 6
    • 0025897075 scopus 로고
    • The effect of chemical protectors oncell cycle progression after gamma or neutron irradiation
    • Sigdestad, C. B., Berquist, B., and Grdina, D. J. The effect of chemical protectors oncell cycle progression after gamma or neutron irradiation. Cell Prolif., 24: 271-280, 1991.
    • (1991) Cell Prolif. , vol.24 , pp. 271-280
    • Sigdestad, C.B.1    Berquist, B.2    Grdina, D.J.3
  • 7
    • 0031473153 scopus 로고    scopus 로고
    • WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II α leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells
    • Murley, J. S., Constantinou, A., Kamath, N. S., and Grdina, D. J. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II α leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif., 30: 283-294, 1997.
    • (1997) Cell Prolif. , vol.30 , pp. 283-294
    • Murley, J.S.1    Constantinou, A.2    Kamath, N.S.3    Grdina, D.J.4
  • 8
    • 0034003770 scopus 로고    scopus 로고
    • The use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells
    • in press
    • Snyder, R. D. The use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ. Mol. Mutagen., in press, 2000.
    • (2000) Environ. Mol. Mutagen.
    • Snyder, R.D.1
  • 9
    • 0021987630 scopus 로고
    • Measurement of micronuclei in human lymphocytes
    • Fenech, M., and Morley, A. A. Measurement of micronuclei in human lymphocytes, Mutat. Res., 147: 29-36, 1985.
    • (1985) Mutat. Res. , vol.147 , pp. 29-36
    • Fenech, M.1    Morley, A.A.2
  • 10
    • 0028953642 scopus 로고
    • Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-toxic and anti-mutagenic mechanisms of action
    • Lond.
    • Grdina, D. J., Shigematsu, N., Dale, P., Newton, G. L., and Aguilera, J. A. Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-toxic and anti-mutagenic mechanisms of action. Carcinogenesis (Lond.), 16: 767-774, 1995.
    • (1995) Carcinogenesis , vol.16 , pp. 767-774
    • Grdina, D.J.1    Shigematsu, N.2    Dale, P.3    Newton, G.L.4    Aguilera, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.