Differential production of IFN-γ, analyzed at the single-cell level, by specific subsets of human NK and T cells from healthy and HIV+ subjects

Cytometry

Volumn 39, Issue 3, 2000, Pages 189-194

  Vitale, Marco ^a,b,c   Caruso, Arnaldo ^a   Licenziati, Stefano ^a   Rodella, Luigi ^a   Fiorentini, Simona ^a   Zauli, Giorgio ^d   Castelli, Francesco ^a   Manzoli, Francesco A ^e   Turano, Adolfo ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b Inst Norm Pathol C   (Italy)

^c Division of Human Anatomy   (Italy)

^d UNIVERSITY OF CHIETI   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Flow cytometry; HIV; IFN ; NK cells

Indexed keywords

CD3 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IONOMYCIN; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE CULTURE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD56; ANTIGENS, CD8; CELLS, CULTURED; FLOW CYTOMETRY; HIV SERONEGATIVITY; HIV SEROPOSITIVITY; HUMANS; INTERFERON TYPE II; IONOMYCIN; KILLER CELLS, NATURAL; KINETICS; LYMPHOCYTE ACTIVATION; MONENSIN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034161271     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0320(20000301)39:3<189::AID-CYTO3>3.0.CO;2-C     Document Type: Article

References (38)

1. Trinchieri G. Biology of natural killer cells. Adv Immunol 1989;47:187-376.
2. Bohem U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-γ. Annu Rev Immunol 1997;15:749-795.
3. Rosa FM, Cochet MM, Fellous M. Interferon and major histocompatibility complex genes: a model to analyse eukaryotic gene regulation? Interferon 1986;7:48-87.
4. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
5. Trinchieri G, Santoli D. Antiviral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. J Exp Med 1978;147:1314-1325.
6. Wu AJ, Chen ZJ, Tsokos M, O'Connell BC, Ambudkar IS, Baum BJ. Interferon-γ induced cell death in a cultured human salivary gland cell line. J Cell Physiol 1996;167:297-304.
7. Macieijewski J, Selleri C, Anderson S, Young NS. Fas antigen expression on CD34+ human marrow cells in induced by interferon-γ and tumor necrosis factor-α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995;85:3183-3190.
8. Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997;18:263-266.
9. Snapper CM, Yamaguchi H, Moorman MA, Sneed R, Smoot D, Mondt JJ. Natural killer cells induce activated murine B cells to secrete Ig. J Immunol 1993;151:5251-5260.
10. Trinchieri G. Interleukin-12: a proinflammatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-276.
11. Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, Enk A, Steinman RM, Romani N, Schuler RG. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-γ production by T helper 1 cells. Eur J Immunol 1996;26:659-668.
12. Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh C-S, Culpepper JA, Wisocka M, Trinchieri G, Murphy KM, O'Garra A. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995;154:5071-5079.
13. Perussia B, Fanning V, Trinchieri G. A human NK and K cell subset shares with cytotoxic T cells expression of the antigen recognized by antibody OKT8. J Immunol 1983;131:223-231.
14. Vitale M, Zamai L, Neri LM, Manzoli L, Facchini A, Papa S. Natural killer function in flow cytometry. Identification of human lymphoid subsets able to bind to the NK sensitive target K562. Cytometry 1991;12:717-722.
15. Vitale M, Zamai L, Papa S, Mazzotti G, Facchini A, Monti G, Manzoli FA. Natural killer function in flow cytometry. III. Surface markers determination of target-conjugated lymphocytes by dual laser flow cytometry. J Immunol Meth 1992;149:189-196.
16. Rana R, Vitale M, Mazzotti G, Manzoli L, Papa L. Radiosensitivity of human natural killer cells: binding and cytotoxic activities of natural killer cell subsets. Radiol Res 1990;124:96-102.
17. Dickinson AM, Middleton SL, Latham J, Dunn J, Thomas L, Proctor SJ. Cytokine treatment of human bone marrow activates anti-leukaemia effector cells: monitoring of purging by polymerase chain reaction and DNA analysis. Leukemia 1995;9:444-449.
18. dimCD56 cells with a low lytic activity. J Acq Imm Def Syndr Hum Retrov 1995;10:331-340.
19. Gasperini S, Zambello R, Agostini C, Trentin L, Tassinari C, Cadrobbi P, Semenzato G, Cassatella MA. Impaired cytokine production by neutrofils isolated from patients with AIDS. AIDS 1998;12:373-379.
20. + lymphocytes of patients with AIDS synthesyze increased amounts of interferon gamma. J Acq Imm Def Syndr Hum Retrov 1995;10:462-470.
21. Caruso A, Bonfanti C, Colombrita D, Turano A. Natural antibodies to IFN-γ in man and their increase during viral infection. J Immunol 1990;144:685-690.
22. Centers for Disease Control. Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescent and adult. MMWR 1993;41:1-19.
23. Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Meth 1993;159:197-207.
24. Assenmacher M, Schmitz J, Radbruch A. Flow cytometric determination of cytokines in activated murine T helper lymphocytes expression of IL-10 in IFN-γ and IL-4-expressing cells. Eur J Immunol 1994; 24:1097-1101.
25. Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Meth 1995;188:117-128.
26. + T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-color flow cytometry. Clin Exp Immunol 1996;105:517-522.
27. Carter LL, Swain SL. Single cell analyses of cytokine production. Curr Opin Immunol 1997;9:177-182.
28. Anegón I, Cuturi MC, Trinchieri G, Perussia B. Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells. J Exp Med 1988;167:452-472.
29. Billiau A. Interferon-γ: biology and role in pathogenesis. Adv Immunol 1996;62:61-130.
30. Toth FD, Mosborg-Petersen P, Kiss J, Aboagyte-Mathiesen G, Zdravkovic M, Hager H, Ebbsen E. Differential replication of human immunodeficiency virus type 1 in CD8-and CD8+ subsets of Natural Killer cells: relationship to cytokine production pattern. J Virol 1993;67:5879-5888.
31. Brenner BG, Dascal A, Margolese RG, Wainberg MA. Natural killer cell function in patients with acquired immunodeficiency syndrome and related diseases. J Leukocyte Biol 1989;46:75-83.
32. Sirianni MC, Tagliaferri F, Aiuti F. Pathogenesis of natural killer cell deficiency in AIDS. Immunol Today 1990;11:81-82.
33. Pantaleo G, Fauci AS. New concepts in the immunopathogenesis of HIV-infection. Annu Rev Immunol 1995;13:487-512.
34. Ullum H, Gotzsche PC, Victor J, Dickmeiss E, Skinhoj P, Pedersen BK. Defective natural immunity: an early manifestation of human immunodeficiency virus infection. J Exp Med 1995;182:789-799.
35. Forthal DN, Landucci G, Robinson WE Jr. Lymphokine-activated cytotoxicity in peripheral blood mononuclear cells of severely immunocompromised HIV-infected patients. Scand J Immunol 1997;45:91-95.
36. Loubeau M, Ahmad A, Toma E, Menezes J. Enhancement of natural killer and antibody-dependent cytolytic activities of the peripheral blood mononuclear cells of HIV-infected patients by recombinant IL-15. J Acq Imm Def Syndr Hum Retrovir 1997;16:137-145.
37. Gruters RA, Terpstra FG, De Jong R, Van Noesel CJM, Van Lier RAW, Miedema F. Selective loss of T cell functions in different stages of HIV infection. Eur J Immunol 1990;20:1039-1044.
38. Maggi E, Mazzetti M, Ravina A, Annunziato F, De Carli M, Piccinni MP, Manetti R, Carbonari M, Pesce AM, Del Prete G, Romagnani S. Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 1994;265:244-248.