Comparison of antagonistic properties of substance P analogs, spantide I, II and III on evoked tongue jerks in rats

Endocrine Regulations

Volumn 34, Issue 1, 2000, Pages 13-18

  Zubrzycka, M ^a   Janecka, A ^a   Traczyk, W Z ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Cerebral ventricles; Substance P; Substance P antagonists; Trigemino hypoglossal reflex

Indexed keywords

DRUG DERIVATIVE; SPANTIDE; SPANTIDE II; SPANTIDE III; SUBSTANCE P;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; HYPOGLOSSAL NERVE; LONG EVANS RAT; MALE; PHYSIOLOGY; RAT; REFLEX; TONGUE; TRIGEMINAL NERVE;

AMINO ACID SEQUENCE; ANIMALS; ELECTRIC STIMULATION; HYPOGLOSSAL NERVE; MALE; RATS; RATS, LONG-EVANS; REFLEX; SUBSTANCE P; TONGUE; TRIGEMINAL NERVE;

EID: 0034154445     PISSN: 12100668     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (13)

1. FOLKERS K, HAKANSON R, HONG J, XU JC, LEANDER S: Biological evaluation of Substance P antagonists. Br J Pharmacol 83,449-456, 1984
2. FOLKERS K, HAKANSON R, FENG D, XU JC, JANECKA A, WANG Z: Spantide III, a superior tachykinin antagonist with high potency and negligible neurotoxicity. Amino Acids 5,233-240,1993
3. HAKANSON R, LEANDER S, ASANO N, FENG DM FOLKERS K: Spantide III, a novel tachykinin antagonist having high potency and low histamine-releasing effect. Reg Pep 31,75-82,1990
4. HAKANSON R, WANG Z, FOLKERS K: Comparison of Spantide II and CP-96,345 for blockade of tachykinin evoked contraction of smooth muscle. Biomed Biophys Res Commun 178,297-301,1991
5. LJUNGQVIST A, CHU JY, TANG P, BENDER W, HAKANSON R, LEANDER S, ROSELL S, FOLKERS K: Increased potency of antagonists of substance P having asparagine in position 6. Reg Pep 24,283-291,1989
6. LUCZYNSKA M, TRACZYK WZ: Influence of cerebral ventricle perfusion with hexapeptide derivatives of Substance P on evoked tongue jerks in rats. Brain Res198,403-410,1980
7. MAGGI CA, PATTACCHINI R, FENG DM, FOLKERS K: Activity of Spantide I and II at various tachykinin receptors and NK-2 tachykinin receptor subtypes. Eur J Pharmacol 199,127-129,1991
8. MCILWAIN H, RODNIGHT R: Release of neurohyphysial hormones in vitro. J Physiol (London) 190,171-187,1967
9. MIZRAHI J, ESCHER E, CARANIKAS S, D'ORLEANS-JUSTE P, REGOL D: Substance P antagonist active in vitro and in vivo. Eur J Pharmacol 82,101-105,1982
10. REGOLI D, ESCHER E, MIZRAHI J: Substance P structure-activity studies and the development of antagonists. Pharmacology 28,301-320,1984
11. REGOLI D, MIZRAHI J, D'ORLEANS-JUSTE P, DION S, DRAPEAU C, ESCHER E: Substance P antagonists showing some selectivity for different receptor types. Eur J Pharmacol 109,121-125,1985
12. WATLING K: Nonpeptide antagonists herald a new era in tachykinin research. Trends Pharmacol Sci 13,266-269,1992
13. ZUBRZYCKA M, JANECKA A, KOZIOLKIEWICZ W, TRACZYK WZ: Inhibition of tongue reflex in rats by tooth pulp stimulation during cerebral ventricle perfusion with (6-11) substance P analogs. Brain Res 753, 128-132,1997