Sedative and cardiopulmonary effects of medetomidine and reversal with atipamezole in desert tortoises (gopherus agassizii)

Journal of Zoo and Wildlife Medicine

Volumn 31, Issue 1, 2000, Pages 28-35

  Sleeman, Jonathan M ^a   Gaynor, James ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Atipamezole; Blood gas; Desert tortoise; Gopherus agassizii; Medetomidine; Sedation; Ventricular pressure

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ATIPAMEZOLE; ELECTROLYTE; HYPNOTIC SEDATIVE AGENT; IMIDAZOLE DERIVATIVE; MEDETOMIDINE; OXYGEN;

ACID BASE BALANCE; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BREATHING; DRUG ANTAGONISM; DRUG EFFECT; HEART RATE; PH; PHYSIOLOGY; TURTLE;

ACID-BASE EQUILIBRIUM; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; ELECTROLYTES; HEART RATE; HYDROGEN-ION CONCENTRATION; HYPNOTICS AND SEDATIVES; IMIDAZOLES; MEDETOMIDINE; OXYGEN; RESPIRATION; TURTLES;

EID: 0034149273     PISSN: 10427260     EISSN: None     Source Type: Journal    
DOI: 10.1638/1042-7260(2000)031[0028:SACEOM]2.0.CO;2     Document Type: Article

References (29)

1. Bennett, R. A. Anesthesia in reptiles. 1996. In: Mader, D. (ed.). Reptile Medicine and Surgery. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 241-247.
2. Bienzle, D., and C. J. Boyd. 1992. Sedative effects of ketamine and midazolam in snapping turtles (Chelydra serpentina). J. Zoo Wildl. Med. 32: 201-204.
3. Bryant, C. E., K. W. Clarke, and J. Thompson. 1996. Cardiopulmonary effects of medetomidine in sheep and in ponies. Res. Vet. Sci. 60: 267-271.
4. Burton, S., K. A. Lemke, S. L. Ihle, and A. L. Mackenzie. 1998. Effects of medetomidine on serum osmolality; urine volume, osmolality and pH; free water clearance; and fractional clearance of sodium, chloride, potassium, and glucose in dogs. Am. J. Vet. Res. 59: 756-761.
5. Butler, P. J., W. Milsom, and J. Woakes. 1984. Respiratory, cardiovascular and metabolic adjustments during steady-state swimming in the green turtle, Chelonia mydas. J. Comp. Physiol. 154: 167-174.
6. Celly, C. S., W. N. McDonnell, S. S. Young, and W. D. Black. 1997. The comparative hypoxaemic effect of four alpha two adrenoceptor agonists (xylazine, romifidine, detomidine, and medetomidine) in sheep. J. Vet. Pharmacol. Ther. 20: 464-471.
7. Holz, P., and R. M. Holz. 1994. Evaluation of ketamine, ketamine/xylazine, and ketamine/midazolam anesthesia in red-eared sliders (Trachemys scripta elegans). J. Zoo Wildl. Med. 25: 531-537.
8. Jalanka, H. H., and B. O. Roeken. 1990. The use of medetomidine, medetomidine-ketamine combinations, and atipamezole in nondomestic mammals: a review. J. Zoo Wildl. Med. 21: 259-282.
9. Kerr, J., and H. M. Frankel. 1972. Inadequacy of blood drawn by cardiac puncture as a source of respiratory gas measurements in turtles (Pseudemys scripta). Comp. Biochem. Physiol. 73A: 913-915.
10. Ko, J. C. H., J. E. Bailey, L. S. Pablo, and T. G. Heaton-Jones. 1996. Comparison of sedative and cardiorespiratory effects of medetomidine and medetomidine-butorphanol combination in dogs. Am. J. Vet. Res. 57: 535-540.
11. Littel, R. C., G. A. Milliken, W. W. Stroup, and R. D. Wolfinger. 1997. The SAS System for Mixed Models. SAS Institute, Cary, North Carolina.
12. Lock, B. A., D. J. Heard, and P. Dennis. 1998. Preliminary evaluation of medetomidine/ketamine combinations for immobilizations and reversal with atipamezole in three tortoise species. Bull. Assoc. Reptil. Amphib. Vet. 8: 6-9.
13. Malley, D. 1997. Reptile anaesthesia and the practising veterinarian. In Prac. 1997: 351-368.
14. Maugeri, S., J. P. Ferre, L. Intorre, and G. Soldani. 1994. Effects of medetomidine on intestinal and colonic motility in the dog. J. Vet. Pharmacol. Ther. 17: 149-154.
15. McDonnell, W. 1996. Respiratory system. In: Thurmon, J. C., W. J. Tranquilli, and G. J. Benson (eds.). Lumb and Jones' Veterinary Anesthesia, 3rd ed. Williams and Wilkins, Baltimore, Maryland. Pp. 115-147.
16. Muir, W. W., J. A. E. Hubbell, R. T. Skarda, and R. M. Bednarski. 1995. Handbook of Veterinary Anesthesia. Mosby, St. Louis, Missouri. Pp. 30-33.
17. Murray, M. J. 1996. Cardiology and circulation. In: Mader, D. (ed.). Reptile Medicine and Surgery. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 95-103.
18. Norton, T. M., J. Spratt, J. Behler, and K. Hernandez. 1998. Medetomidine and ketamine anesthesia with atipamezole reversal in private free-ranging gopher tortoises, Gopherus polyphemus. Proc. Assoc. Reptil. Amphib. Vet. Pp. 25-27.
19. Oppenheim, Y. C., and P. F. Moon. 1995. Sedative effects of midazolam in red-eared slider turtles (Trachemys scripta elegans). J. Zoo Wildl. Med. 26: 409-413.
20. Page, C. 1993. Current reptilian anesthesia. In: Fowler, M. E. (ed.). Zoo and Wild Animal Medicine. Current Therapy 3. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 141-143.
21. Rooney, M. B., G. Levine, J. Gaynor, E. Macdonald, and J. Wimsatt. 1999. Sevoflurane anesthesia in desert tortoises (Gopherus agassizii). J. Zoo. Wildl. Med. 30: 64-69.
22. Smith, J. A., M. A. Mitchell, K. A. Backues, T. N. Tully, and R. F. Aguilar. 1998. Sedative and cardiopulmonary effects of medetomidine and atipamezole in America alligator (Alligator mississippiensis). Proc. Am. Assoc. Zoo. Vet. Am. Assoc. Wildl. Vet. Joint Conf. 1998: 276-277.
23. Smith, J. A., M. A. Mitchell, and T. N. Tully. 1997. Evaluation of sedative and cardiopulmonary effects of medetomidine and atipamezole in green iguanas (Iguana iguana): preliminary data. Proc. Assoc. Reptil. Amphib. Vet. P. 63.
24. Stein, G. 1996. Hematologic and blood chemistry values in reptiles. In: Mader, D. (ed.). Reptile Medicine and Surgery. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 473-483.
25. Thurmon, J. C., W. J. Tranquilli, and G. J. Benson. 1996. Preanesthetics and anesthetic adjuncts. In: Thurmon, J. C., W. J. Tranquilli, and G. J. Benson (eds.). Lumb and Jones' Veterinary Anesthesia, 3rd ed. Williams and Wilkins, Baltimore, Maryland. Pp. 183-209.
26. Vanio, O. 1990. Reversal of medetomidine-induced cardiovascular and respiratory changes with atipamezole in dogs. Vet. Rec. 127: 447-450.
27. Venugopalan, C. S., E. P. Holmes, V. Fucci, T. J. Keefe, and M. P. Crawford. 1994. Cardiopulmonary effects of medetomidine in heartworm-infected and noninfected dogs. Am. J. Vet. Res. 55: 1148-1152.
28. Wimsatt, J., J. D. Johnson, and B. A. Mangone. 1996. A cardiac access port for repeated blood sampling in the desert tortoise (Gopherus agassizii). Curr. Trends Lab. Anim. Sci. 37: 101-103.
29. Wood, F., K. Critchley, and J. Wood. 1982. Anesthesia in the green sea turtle, Chelonia mydas. Am. J. Vet. Res. 43: 1882-1883.