Cerebrospinal Fluid Pharmacokinetics of Cefpodoxime Proxetil in Piglets

Journal of Clinical Pharmacology

Volumn 40, Issue 3, 2000, Pages 290-295

  Abdel Rahman, Susan M ^a,b,c   Maxson, Suzanne ^d,e   Teo, Charles ^d,e   Hubbard, Amanda E ^a,c   Kearns, Gregory L ^a,b,c  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c CHILDREN S MERCY HOSPITAL   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^e ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFPODOXIME PROXETIL; CEFTIZOXIME; CEPHALOSPORIN DERIVATIVE; DRUG DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; CEREBROSPINAL FLUID; SWINE;

ANIMALS; CEFTIZOXIME; CEPHALOSPORINS; SWINE;

EID: 0034146612     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700022008964     Document Type: Article

References (21)

1. Cefpodoxime proxetil: a new oral cephalosporin. Med Lett Drugs Ther 1992;34(884):107-108.
2. Fujii R: Clinicl trials of cefpodoxime proxetil suspension in paediatric patients. Drugs 1991;42(Suppl. 3):57-60.
3. Del Tacca M, Danesi R, Blandizzi C, Zolfino I, Senesi S, Panattoni E, Gabriele M, Marcucci M, Favini P, Campa M: Periodontal tissue distribution of cefpodoxime proxetil and efficacy in acute odontogenic infections. Drug Invest 1993;5:313-319.
4. O'Neill P, Nye K, Douce G, Andrews J, Wise R: Pharmacokinetics and inflammatory fluid penetration of cefpodoxime proxetil in volunteers. Antimicrob Agents Chemother 1990;34:232-234.
5. Borin MT, Hughes GS, Spillers CR, Patel RK: Pharmacokinetics of cefpodoxime in plasma and skin blister fluid following oral dosing of cefpodoxime proxetil. Antimicrob Agent Chemother 1990;34: 1094-1099.
6. Bairamis TN, Nikolopoulos TP, Kafetzis DA, Begue P, Lenfant B, Kandiloros DC, Apostolopouos NJ: Concentrations of cefpodoxime in plasma, adenoid, and tonsillar tissue after repeated administrations of cefpodoxime proxetil in children. J Antimicrob Chemother 1996;37:821-824.
7. Borin MT: A review of the pharmacokinetics of cefpodoxime proxetil. Drugs 1991;42(Suppl. 3):13-21.
8. Steenwyk RC, Brewer JE, Royer ME, Cathcart KS: Reversed-phase liquid chromatographic determination of cefpodoxime in human plasma. J Liq Chromatog 1991;14:3641-3656.
9. Yamaoka K, Nakagawa T, Uno T: Application of Akaike's Information Criterion (AIC) in evaluation of linear pharmacokinetic equations. J Pharmacokin Biopharm 1978;6:165-175.
10. Schmidt T, Tauber MG: Pharmacodynamics of antibiotics in the therapy of meningitis: infection model observations. J Antimicrob Chemother 1993;31(Suppl. D):61-70.
11. Temesvari P, Abraham CS, Speer CP, Kovacs J, Megyeri P: Escherichia coli 0111 lipopolysaccharide given intracisternally induces blood-brain barrier opening during experimental neonatal meningitis in piglets. Pediatr Res 1993;34:182-186.
12. Dodds WJ: The pig model for biomedical research. Fed Proc 1982;41:247-256.
13. Friis C: Postnatal development of renal function in piglets: glomerular filtration rate, clearance of PAH and PAH extraction. Biol Neonate 1979;35:180-187.
14. Kearns GL, Hill DE, Thronberry CM, Young JF: Theophylline and caffeine disposition in the neonatal piglet. Devel Pharmacol Ther 1986; 9:389-401.
15. Chandler CJ, Ong BY, Sitar DS: Kinetic disposition of ethanol in the neonatal piglet and hemodynamic effects in the presence and absence of 4-methylpyrazole. Toxicol Appl Pharmacol 1989;99:185-192.
16. Kearns GL, Young JF: Disposition of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZE) in serum and lymph. Pediatr Res 1992;31:61A.
17. Kearns GL, Darville T, Wells TG, Jacobs RF, Hughes GS, Borin MT: Single dose pharmacokinetics of cefpodoxime proxetil in infants and children. Drug Invest 1994;7:221-233.
18. Trang JM, Jacobs RF, Kearns GL, Brown AL, Wells TG, Underwood FL, Kluza RB: Cefotaxime and desacetylcefotaxime pharmacokinetics in infants and children with meningitis. Antimicrob Agent Chemother 1985;28:791-795.
19. Jacobs RF, Kearns GL, Brown AL, Longee DC: Cerebrospinal fluid penetration of imipenem and cilastatin (Primaxin) in children with central nervous system infections. Antimicrob Agent Chemother 1986;29:670-674.
20. Valentini S, Coratza G, Rossolini GM, Massidda O, Satta G: In vitro evaluation of cefpodoxime. J Antimicrob Chemother 1994;33: 495-508.
21. Quagliarello VJ, Scheld WM: Treatment of bacterial meningitis. N Engl J Med 1997;336:708-716.