A controlled, double-blind, randomized pilot clinical trial of nicardipine as compared with a placebo in patients with moderate or severe head injury;Ensayo clinico piloto, controlado, doblemente ciego, aleatorizado de nicardipino frente a placebo en pacientes afectados de traumatismo craneal grave o moderado

Revista de Neurologia

Volumn 30, Issue 5, 2000, Pages 401-408

  Sahuquillo, J ^a  

^a Unidad de Investigación de Neurotraumatología   (Spain)

Author keywords

Cerebral vasospasm; Clinical trial; Head injury; Nicardipine; Posttraumatic subarachnoid hemorrhage. Transcranial Doppler; Treatment; Ultrasonography

Indexed keywords

NICARDIPINE; PLACEBO; VASODILATOR AGENT;

ADULT; ANISOCORIA; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW VELOCITY; BRAIN VASOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEAD INJURY; HEART ARRHYTHMIA; HUMAN; HYPOTENSION; MALE; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; SUBARACHNOID HEMORRHAGE; BLOOD PRESSURE; BRAIN; BRAIN INJURY; COMPUTER ASSISTED TOMOGRAPHY; GLASGOW COMA SCALE; INTRAVENOUS DRUG ADMINISTRATION; PHYSIOLOGY; RADIOGRAPHY; TIME; TREATMENT OUTCOME; VASCULARIZATION;

ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN; BRAIN INJURIES; DOUBLE-BLIND METHOD; FEMALE; GLASGOW COMA SCALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; NICARDIPINE; PILOT PROJECTS; SUBARACHNOID HEMORRHAGE, TRAUMATIC; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; VASODILATOR AGENTS; VASOSPASM, INTRACRANIAL;

EID: 0034145085     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3005.99063     Document Type: Article

References (10)

1. 2+ in isolated cerebral arteries. Eur J Pharmacol 1992; 229: 83-9.
2. Kakarieka A, Schakel EH, Fritze J. Clinical experiences with nimodipine in cerebral ischemia. J Neural Transm Suppl 1994; 43: 13-21.
3. Hubschmann OR, Kornhauser D. Effects of intraparenchymal hemorrhage in extracellular cortical potassium in experimental head trauma. J Neurosurg 1983; 59: 289-93.
4. Tsukahara T, Arista A, Kassell NF. The distribution of intravenous nicardipine in rat brain after subarachnoid hemorrhage. Surg Neurol 1989; 32: 188-94.
5. Flamm ES, Adams HP, Beck DW, Pinto RS, Marler JR, Walker MD, et al. Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 1988; 68: 393-400.
6. Haley EC, Kassell NF, Torner JC and the participants in the Cooperative Aneurysm Study. A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. J Neurosurg 1993; 78: 537-47.
7. Haley EC, Kassell NF, Torner JC and the participants in the Cooperative Aneurysm Study. A randomized trial of nicardipine in subarachnoid hemorrhage: Angiographie and transcranial Doppler ultrasound results. A report of the Cooperative Aneurysm Study. J Neurosurg 1993; 78: 548-53.
8. Haley EC, Kassell NF, Torner JC, Truskowski LL, Germanson TP and the participants in the Cooperative Aneurysm Study. A randomized trial of two doses of nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. J Neurosurg 1994; 80: 788-96.
9. Harders A, Kakarieka A, Braakman R, the German tS AH Study Group. Traumatic subarachnoid hemorrhage and its treatment with nimodipine. J Neurosurg 1996; 85: 82-9.
10. Kostron H, Rumpl E, Stampfl, Russegger L, Grunert V. Treatment of cerebral vasospasm following severe head injury with the calcium influx blocker nimodipine. Neurochirurgia 1985; 28: 103-9.