Biodistribution and bioactivity of tetra-pegylated meta-tetra(hydroxyphenyl)chlorin compared to native meta-tetra(hydroxyphenyl)chlorin in a rat liver tumor model

Photochemistry and Photobiology

Volumn 71, Issue 2, 2000, Pages 211-217

  Rovers, Jeroen P ^a,b   Saarnak, Anne E ^c   De Jode, Martin ^a   Sterenborg, Hendricus J C M ^d   Terpstra, Onno T ^b   Grahn, Michael F ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

3 TETRA(HYDROXYPHENYL)CHLORIN; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG UPTAKE; IRRADIATION; LIVER; LIVER TUMOR; MALE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; RAT; TUMOR NECROSIS;

ADENOCARCINOMA; ANIMALS; LIGHT; LIVER; LIVER NEOPLASMS; MALE; MESOPORPHYRINS; PHOTOSENSITIZING AGENTS; POLYETHYLENE GLYCOLS; RATS; RATS, INBRED STRAINS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0034143193     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2000)071<0211:BABOTP>2.0.CO;2     Document Type: Article

References (29)

1. Henderson, B. W. and T. J. Dougherty (1992) How does photodynamic therapy work? Photochem. Photobiol. 55, 145-157.
2. Schuitmaker, J. J., P. Baas, H. L. van Leengoed, F. W. van der Meulen, W. M. Star and N. van Zandwijk (1996) Photodynamic therapy: a promising new modality for the treatment of cancer. J. Photochem. Photobiol. B 34, 3-12.
3. Amano, T., G. R. Prout, Jr. and C. W. Lin (1988) Intratumor injection as a more effective means of porphyrin administration for photodynamic therapy. J. Urol. 139, 392-395.
4. Goff, B. A., J. Blake, M. P. Bamberg and T. Hasan (1996) Treatment of ovarian cancer with photodynamic therapy and immunoconjugates in a murine ovarian cancer model. Br. J. Cancer 74, 1194-1198.
5. Duncan, R. and F. Spreafico (1994) Polymer conjugates. Pharmacokinetic considerations for design and development. Clin. Pharmacokinet. 27, 290-306.
6. Maeda, H. and Y. Matsumura (1989) Tumouritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst. 6, 193-210.
7. Seymour, L. W. (1992) Passive tumour targeting of soluble macromolecules and drug conjugates. CRC Crit. Rev. Ther. Drug Carrier Syst. 9, 135-187.
8. Bonnett, R., A. N. Nizhnik, S. G. White and M. C. Berenbaum (1990) Porphyrin sensitizers in tumour phototherapy. Novel sensitizers of the chlorin and bacteriochlorin class with amphiphilic properties. J. Photochem. Photobiol. B Biol. 6, 29-37.
9. Ris, H. B., H. J. Altermatt, R. Inderbitzi, R. Hess, B. Nachbur, J. C. Stewart, Q. Wang, C. K. Lim, R. Bonnett, M. C. Berenbaum and U. Althaus (1991) Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. Br. J. Cancer 64, 1116-1120.
10. Dilkes, M. G., M. L. de Jode, Q. Gardiner, G. S. Kenyon and P. McKelvie (1995) Treatment of head and neck cancer with photodynamic therapy: results after one year. J. Laryngol. Otol. 109, 1072-1076.
11. Grahn, M. F., A. Giger, A. McGuinness, M. L. de Jode, J. C. M. Stewart, H. B. Ris, H. J. Altermatt and N. S. Williams (1999) mTHPC polymer conjugates: the in vivo photodynamic activity of four candidate compounds. Lasers Med Sci. 14, 40-46.
12. Basu, A., M. de Jode, M. F. Grahn and N. S. Williams (1998) Comparison of cutaneous photosensitivity of mTHPC and a polyethylene glycol derivative (sc102). Lasers Surg. Med. 10(Suppl.), 29. [Abstract]
13. Marquet, R. L., D. L. Westbroek and J. Jeekel (1984) Interferon treatment of a transplantable rat colon adenocarcinoma: importance of tumor site. Int. J. Cancer 33, 689-692.
14. Saarnak, A. E. (1999) Evaluation of Fluorescence Measurement Techniques for Tumour Detection In Vivo. University of Amsterdam, Amsterdam.
15. Lilge, L., C. O'Carroll and B. C. Wilson (1997) A solubilization technique for photosensitizer quantification in ex vivo tissue samples. J. Photochem. Photobiol. B 39, 229-235.
16. Bellnier, D. A., Y. K. Ho, R. K. Pandey, J. R. Missert and T. J. Dougherty (1989) Distribution and elimination of Photofrin II in mice. Photochem. Photobiol. 50, 221-228.
17. Westermann, P., T. Glanzmann, S. Andrejevic, D. R. Braichotte, M. Forrer, G. A. Wagnieres, P. Monnier, H. van den Bergh, J. P. Mach and S. Folli (1998) Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma. Int. J. Cancer 76, 842-850.
18. Ris, H.-B., T. Krueger, A. Giger, C. K. Lim, J. C. M. Stewart, U. Althaus and H. J. Altermatt (1999) Photodynamic therapy with mTHPC and polyethylene glycol-derived mTHPC: a comparative study on human tumour xenografts. Br. J. Cancer 79, 1061-1066.
19. Seymour, L. W., Y. Miyamoto, H. Maeda, M. Brereton, J. Strohalm, K. Ulbrich and R. Duncan (1995) Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur. J. Cancer 31A, 766-770.
20. Yamaoka, T., Y. Tabata and Y. Ikada (1994) Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice. J. Pharm. Sci. 83, 601-606.
21. Rovers, J. P., A. E. Saarnak, A. Molina, J. J. Schuitmaker, H. J. C. M. Sterenborg and O. T. Terpstra (1999) Effective treatment of liver metastases with photodynamic therapy, using the second generation photosensitizer meta-tetra(hydroxyphenyl)chlorin (mTHPC), in a rat model. Br. J. Cancer 81, 600-608.
22. Grahn, M. F., A. McGuinness, M. L. de Jode, A. Giger, A. S. Dhiman, C. M. Cheung, S. Pavitt, R. Benzie and N. S. Williams (1997) In vivo photodynamic activity of mTHPC poly(ethylene glycol) conjugates (SC102). Proc. SPIE 3191, 180-186.
23. Basu, A., M. de Jode, M. F. Grahn and N. S. Williams (1998) SC102 mediated intra-abdominal photodynamic therapy is safe for colorectal cancer. Lasers Surg. Med. 10(Suppl.), 28. [Abstract]
24. Hornung, R., B. Jentsch, N. E. Crompton, U. Haller and H. Walt (1997) In vitro effects and localisation of the photosensitizers m-THPC and m-THPC MD on carcinoma cells of the human breast (MCF-7) and Chinese hamster fibroblasts (V-79). Lasers Surg. Med. 20, 443-450.
25. Muller, S., H. Walt, D. Dobler-Girdziunaite, D. Fiedler and U. Haller (1998) Enhanced photodynamic effects using fractionated laser light. J. Photochem. Photobiol. B 42, 67-70.
26. Peng, Q., J. Moan and J. M. Nesland (1996) Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct. Pathol. 20, 109-129.
27. Kopecek, J. (1984) Controlled biodegradability of polymers - a key to drug delivery systems. Biomaterials 5, 19-25.
28. Ris, H. B., A. Giger, V. I. Hof, D. Mettler, J. C. Stewart, U. Althaus and H. J. Altermatt (1997) Experimental assessment of photodynamic therapy with chlorins for malignant mesothelioma. Eur. J. Cardiothorac. Surg. 12, 542-548.
29. Ris, H. B., V. Im Hof, C. M. Stewart, D. Mettler and H. J. Altermatt (1998) Endobronchial photodynamic therapy: comparison of mTHPC and polyethylene glycol-derived mTHPC on human tumor xenografts and tumor-free bronchi of minipigs. Lasers Surg. Med. 23, 25-32.