Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine

Acta Pharmacologica Sinica

Volumn 21, Issue 2, 2000, Pages 124-130

  Si Yuan, Pan ^a   Yi Fan, Han ^b  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Anisodamine; Anisodine; Atropine; Avoidance learning; Belladonna alkaloids; Memory; Motor activity; Scopolamine; Tacrine

Indexed keywords

ANISODAMINE; ANISODINE; ATROPINE; BELLADONNA ALKALOID; SCOPOLAMINE; TACRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; DRUG ANTAGONISM; LEARNING; LOCOMOTION; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; SHOCK;

ANIMALS; ATROPINE; AVOIDANCE LEARNING; CHOLINESTERASE INHIBITORS; LEARNING DISORDERS; MALE; MICE; MOTOR ACTIVITY; MUSCARINIC ANTAGONISTS; RETENTION (PSYCHOLOGY); SCOPOLAMINE; SCOPOLAMINE DERIVATIVES; SOLANACEOUS ALKALOIDS; TACRINE;

EID: 0034142088     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Perry EK, Smith CJ, Court JA, Perry RH. Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types. J Neural Transm [P-D Sect] 1990; 2: 149-58.
2. Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, Quirion R. Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 1988; 50: 1914-23.
3. Hunter AJ, Murray TK, Jones JA, Cross AJ, Green AR. The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro. Br J Pharmacol 1989; 98: 79-86.
4. Farlow M, Gracon SI, Hershey LA, Lewis KW, Sadowsky CH, Dolan-Ureno J. A controlled trial of tacrine in Alzheimer's disease. J Am Med Assoc 1992; 268: 2523-9.
5. Davis KL, Thal LJ, Gamzu ER, Davis CS, Woolson RF, Gracon SI, et al. A double-blind, placebo-controlled multi-center study of tacrine for Alzheimer's disease. New Engl J Med 1992; 327: 1253-9.
6. Jackson JJ, Soliman MR. Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions. Life Sci 1996; 58: 47-54.
7. Rupniak NM, Tye SJ, Field MJ. Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys. Psychopharmacology 1997; 131: 406-10.
8. Smith RD, Kistler MK, Cohen-Williams M, Coffin VL. Cholinergic improvement of a naturally-occurring memory deficit in the young rat. Brain Res 1996; 707: 13-21.
9. Pan SY, Xu QP, Jiang MY, Hou JY, Wang LY, Han PT, et al. Pharmacological studies of extracts of Dangshen (Codonopsis Pilosula) on the central nervous system. Chin Trad Herb Drugs 1987; 18: 307-11.
10. Xu QY, Liu WX, Chen CM, Di WL. Effects of anisodamine on blood coagulation, fibrin and thrombosis in rabbits. Acta Pharmacol Sin 1990; 11: 44-7.
11. Zhang S, Liu J, He L. Anisodamine (654-2) improves impaired cognitive function induced by experimental brain damage. Acta Acad Med Sin 1995; 17: 254-8.
12. Pan SY, Han YF, Xu QP, Liu MY, Ma HZ, Ding WJ, et al. Belladonna alkaloids-induced behavioral changes and amnesia on open-field and stepthrough in 18-, 28-, and 38-day-old mice. Acta Pharmacol Sin 1998; 19: 112-6.
13. Pan SY. Circadian effects of scopolamine on memory, exploratory behavior, and muscarinic receptors in mouse brain. Acta Pharmacol Sin 1992; 13: 323-6.
14. Eguchi J, Yuasa T, Egawa M, Tobe A. Effects of a novel compound MCI-225 on impaired learning and memory in rats. Pharmacol Biochem Behav 1994; 48: 345-9.
15. Pan SY. Features of memory on novel situation and avoidance response; evidence from comparisons between open-field behavior and step-through task. Acta Pharmacol Sin 1995; 16: 125-9.